Package: BBMBC 1.0.1

BBMBC: Beta-Binomial Models for Immune Cell Frequencies and Power Calculations

Provides tools to model overdispersed immune cell frequencies using Beta-Binomial generalized linear models. Originally designed for memory B cells, the framework generalizes to evaluate rare cellular immune responses across vaccinology, immuno-oncology, and related fields. Includes method-of-moments dispersion estimation, likelihood ratio testing across experimental arms, and Monte Carlo simulation to calculate statistical power and Type I error rates. The methodologies are directly motivated by the analysis of immunology data in "Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial" (Parks et al. 2025) <doi:10.1126/scitranslmed.ady6831>.

Authors:Andrew Shin [aut, cre]