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# CITATION.cff file created with {cffr} R package
# See also: https://docs.ropensci.org/cffr/
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cff-version: 1.2.0
message: 'To cite package "BBMBC" in publications use:'
type: software
license: MIT
title: 'BBMBC: Beta-Binomial Models for Immune Cell Frequencies and Power Calculations'
version: 1.0.1
doi: 10.32614/CRAN.package.BBMBC
abstract: Provides tools to model overdispersed immune cell frequencies using Beta-Binomial
  generalized linear models. Originally designed for memory B cells, the framework
  generalizes to evaluate rare cellular immune responses across vaccinology, immuno-oncology,
  and related fields. Includes method-of-moments dispersion estimation, likelihood
  ratio testing across experimental arms, and Monte Carlo simulation to calculate
  statistical power and Type I error rates. The methodologies are directly motivated
  by the analysis of immunology data in "Vaccination with mRNA-encoded membrane-anchored
  HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical
  trial" (Parks et al. 2025) <https://doi.org/10.1126/scitranslmed.ady6831>.
authors:
- family-names: Shin
  given-names: Andrew
  email: ashin2@uw.edu
repository: https://cran.r-universe.dev
commit: 5bae70e736108e6d714f604b5fbf2e5be16218f0
date-released: '2026-10-31'
contact:
- family-names: Shin
  given-names: Andrew
  email: ashin2@uw.edu