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  "Title": "Beta-Binomial Models for Immune Cell Frequencies and Power\nCalculations",
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  "Description": "Provides tools to model overdispersed immune cell\nfrequencies using Beta-Binomial generalized linear models.\nOriginally designed for memory B cells, the framework\ngeneralizes to evaluate rare cellular immune responses across\nvaccinology, immuno-oncology, and related fields. Includes\nmethod-of-moments dispersion estimation, likelihood ratio\ntesting across experimental arms, and Monte Carlo simulation to\ncalculate statistical power and Type I error rates. The\nmethodologies are directly motivated by the analysis of\nimmunology data in \"Vaccination with mRNA-encoded\nmembrane-anchored HIV envelope trimers elicited tier 2\nneutralizing antibodies in a phase 1 clinical trial\" (Parks et\nal. 2025) <doi:10.1126/scitranslmed.ady6831>.",
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