Package: BBMBC
Title: Beta-Binomial Models for Immune Cell Frequencies and Power
        Calculations
Version: 1.0.1
Authors@R: 
    person("Andrew", "Shin", , "ashin2@uw.edu", role = c("aut", "cre"))
Description: Provides tools to model overdispersed immune cell
        frequencies using Beta-Binomial generalized linear models.
        Originally designed for memory B cells, the framework
        generalizes to evaluate rare cellular immune responses across
        vaccinology, immuno-oncology, and related fields. Includes
        method-of-moments dispersion estimation, likelihood ratio
        testing across experimental arms, and Monte Carlo simulation to
        calculate statistical power and Type I error rates. The
        methodologies are directly motivated by the analysis of
        immunology data in "Vaccination with mRNA-encoded
        membrane-anchored HIV envelope trimers elicited tier 2
        neutralizing antibodies in a phase 1 clinical trial" (Parks et
        al. 2025) <doi:10.1126/scitranslmed.ady6831>.
Encoding: UTF-8
Depends: R (>= 4.1.0)
Imports: doParallel, foreach, glmmTMB, parallel, stats, utils
Suggests: testthat (>= 3.0.0)
Config/testthat/edition: 3
Config/roxygen2/version: 8.0.0
License: MIT + file LICENSE
NeedsCompilation: no
Packaged: 2026-10-31 18:52:47 UTC; root
Author: Andrew Shin [aut, cre]
Maintainer: Andrew Shin <ashin2@uw.edu>
Repository: https://cran.r-universe.dev
Date/Publication: 2026-10-31 12:48:14 UTC
RemoteUrl: https://github.com/cran/BBMBC
RemoteRef: HEAD
RemoteSha: 5bae70e736108e6d714f604b5fbf2e5be16218f0