Package: dtptite 0.1.0
Xiaoran Lai
dtptite: Dose Transition Pathways for Time-to-Event Dose-Finding Designs
Implements the Dose Transition Pathways (DTP) look-ahead strategy for time-to-event phase I dose-finding clinical trials with delayed or pending toxicity outcomes. Provides a DTP decorator for the 'escalation' framework, supporting both TITE-CRM (model-based) and TITE-BOIN (model-assisted) base designs.
Authors:
dtptite_0.1.0.tar.gz
dtptite_0.1.0.zip(r-4.7-any)dtptite_0.1.0.zip(r-4.6-any)
dtptite_0.1.0.tar.gz(r-4.7-any)dtptite_0.1.0.tar.gz(r-4.6-any)
dtptite_0.1.0.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
DESCRIPTION |NEWS
card.svg |card.png
dtptite/json (API)
| # Install 'dtptite' in R: |
| install.packages('dtptite', repos = c('https://cran.r-universe.dev', 'https://cloud.r-project.org')) |
Bug tracker:https://github.com/icr-epat/dtptite/issues
Last updated from:da91febff1. Checks:6 OK. Indexed: yes.
| Target | Result | Time | Files | Syslog |
|---|---|---|---|---|
| linux-devel | OK | 272 | ||
| source / vignettes | OK | 217 | ||
| linux-release | OK | 299 | ||
| windows-devel | OK | 309 | ||
| windows-release | OK | 315 | ||
| wasm-release | OK | 144 |
Exports:apply_dtpdtp_projected_dosedtp_should_waitdtp_wait_eventsdtp_wait_summarydtp_wait_timeget_boin_titescenario_mtdset_dtp_queue_sizestop_for_beta_binomial_toxicitytime_to_first_mtdtite_patient_samples
Dependencies:abindarrayhelpersbackportsbase64encBHbinombitbit64BOINbriobslibcachemcallrcheckmateclicliprcodacpp11crayondescdfcrmDiagrammeRdiffobjdigestdistributionaldplyrescalationevaluatefarverfastmapfontawesomefsgenericsggdistggplot2gluegridExtragtablegtoolshighrhmshtmltoolshtmlwidgetsigraphinlineIsoisobandjquerylibjsonliteknitrlabelinglatticelifecycleloomagrittrMASSMatrixmatrixStatsmemoisemimemvtnormnumDerivotelpillarpkgbuildpkgconfigpkgloadposteriorpraiseprettyunitsprocessxprogresspspurrrquadprogQuickJSRR6rappdirsRColorBrewerRcppRcppEigenRcppParallelreadrrlangrmarkdownrprojrootrstanrstantoolsrstudioapiS7sassscalesStanHeadersstringistringrsvUnittensorAtestthattibbletidybayestidyrtidyselecttinytextrialrtzdbutf8vctrsviridisviridisLitevisNetworkvroomwaldowithrxfunyaml
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| Apply the DTP look-ahead to a TITE selector factory. | apply_dtp |
| Projected dose after waiting. | dtp_projected_dose |
| Should the trialist wait before dosing the next cohort? | dtp_should_wait |
| Raw DTP wait event log from simulated trials. | dtp_wait_events |
| Per-trial DTP wait summary from simulated trials. | dtp_wait_summary |
| Minimum wait time before the dose recommendation changes. | dtp_wait_time |
| Create a TITE-BOIN dose-finding selector. | get_boin_tite |
| Plot the cumulative incidence of reaching the MTD. | plot.time_to_first_mtd |
| True MTD of a simulated scenario. | scenario_mtd |
| Set the waiting-room capacity for DTP simulation. | set_dtp_queue_size |
| Stop for excessive toxicity using a Beta-Binomial conjugate posterior. | stop_for_beta_binomial_toxicity |
| Summarise time-to-first-MTD across replicates. | summary.time_to_first_mtd |
| Time until the first patient is dosed at the true MTD. | time_to_first_mtd |
| Create patient samples with realistic TITE DLT timing. | tite_patient_samples |