{
  "_id": "6ad8fad9c230b829876fd1a0",
  "Package": "dtptite",
  "Title": "Dose Transition Pathways for Time-to-Event Dose-Finding Designs",
  "Version": "0.1.0",
  "Authors@R": "c(\nperson(\"Xiaoran\", \"Lai\", , \"xiaoran.lai@icr.ac.uk\", role = c(\"aut\", \"cre\")),\nperson(\"The Institute of Cancer Research\", role = \"cph\"),\nperson(\"National Institute for Health and Care Research\", role = \"fnd\")\n)",
  "Description": "Implements the Dose Transition Pathways (DTP) look-ahead\nstrategy for time-to-event phase I dose-finding clinical trials\nwith delayed or pending toxicity outcomes. Provides a DTP\ndecorator for the 'escalation' framework, supporting both\nTITE-CRM (model-based) and TITE-BOIN (model-assisted) base\ndesigns.",
  "License": "GPL (>= 3)",
  "URL": "https://github.com/ICR-EPAT/dtptite",
  "BugReports": "https://github.com/ICR-EPAT/dtptite/issues",
  "Config/testthat/edition": "3",
  "Encoding": "UTF-8",
  "RoxygenNote": "7.3.3",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-10-21 17:42:09 UTC",
    "User": "root"
  },
  "Author": "Xiaoran Lai [aut, cre], The Institute of Cancer Research [cph],\nNational Institute for Health and Care Research [fnd]",
  "Maintainer": "Xiaoran Lai <xiaoran.lai@icr.ac.uk>",
  "Repository": "https://cran.r-universe.dev",
  "Date/Publication": "2026-10-21 15:23:33 UTC",
  "RemoteUrl": "https://github.com/cran/dtptite",
  "RemoteRef": "HEAD",
  "RemoteSha": "da91febff1fe9fa71ea703ec49b12c98cb0be1ef",
  "_user": "cran",
  "_type": "src",
  "_file": "dtptite_0.1.0.tar.gz",
  "_fileid": "https://r2.ropensci.org/7ac39997a1a16009157f2fe1db89900513c26b0900facf70664a9dc0bba98198",
  "_filesize": 210831,
  "_sha256": "7ac39997a1a16009157f2fe1db89900513c26b0900facf70664a9dc0bba98198",
  "_expires": "2027-01-29T17:48:07.000Z",
  "_created": "2026-10-21T17:42:09.000Z",
  "_published": "2026-10-21T17:48:09.597Z",
  "_upstream": "https://github.com/cran/dtptite",
  "_status": "success",
  "_maintainer": {
    "name": "Xiaoran Lai",
    "email": "xiaoran.lai@icr.ac.uk",
    "login": "xlai",
    "description": "",
    "uuid": 6449900
  },
  "_jobs": [
    {
      "job": 119382311411,
      "time": 272,
      "config": "linux-devel-x86_64",
      "r": "4.7.0",
      "check": "OK",
      "artifact": "12368101132"
    },
    {
      "job": 119382311619,
      "time": 299,
      "config": "linux-release-x86_64",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "12367761612"
    },
    {
      "job": 119380422031,
      "time": 217,
      "config": "source",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "12367735761"
    },
    {
      "job": 119382311445,
      "time": 144,
      "config": "wasm-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "12366658461"
    },
    {
      "job": 119382311364,
      "time": 309,
      "config": "windows-devel-x86_64",
      "r": "4.7.0",
      "check": "OK",
      "artifact": "12366943547"
    },
    {
      "job": 119382312050,
      "time": 315,
      "config": "windows-release-x86_64",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "12368505790"
    }
  ],
  "_buildurl": "https://github.com/r-universe/cran/actions/runs/39645610489",
  "_commit": {
    "id": "da91febff1fe9fa71ea703ec49b12c98cb0be1ef",
    "author": "Xiaoran Lai <xiaoran.lai@icr.ac.uk>",
    "committer": "cran-robot <csardi.gabor+cran@gmail.com>",
    "message": "version 0.1.0\n",
    "time": 1792596213
  },
  "_distro": "resolute",
  "_host": "GitHub-Actions",
  "_registered": true,
  "_dependencies": [
    {
      "package": "R",
      "version": ">= 4.1.0",
      "role": "Depends"
    },
    {
      "package": "BOIN",
      "role": "Imports"
    },
    {
      "package": "dplyr",
      "role": "Imports"
    },
    {
      "package": "escalation",
      "version": ">= 0.2.0",
      "role": "Imports"
    },
    {
      "package": "stats",
      "role": "Imports"
    },
    {
      "package": "tibble",
      "role": "Imports"
    },
    {
      "package": "dfcrm",
      "role": "Suggests"
    },
    {
      "package": "ggplot2",
      "role": "Suggests"
    },
    {
      "package": "testthat",
      "version": ">= 3.0.0",
      "role": "Suggests"
    },
    {
      "package": "TITEgBOIN",
      "role": "Suggests"
    }
  ],
  "_owner": "cran",
  "_selfowned": false,
  "_usedby": 0,
  "_updates": [
    {
      "week": "2026-43",
      "n": 1
    }
  ],
  "_tags": [
    {
      "name": "0.1.0",
      "date": "2026-10-21"
    }
  ],
  "_stars": 0,
  "_contributors": [
    {
      "user": "xlai",
      "count": 1,
      "uuid": 6449900
    }
  ],
  "_userbio": {
    "uuid": 6899542,
    "type": "organization",
    "name": "cran",
    "followers": 634,
    "description": "Unofficial read-only mirror of all CRAN R packages"
  },
  "_downloads": {
    "count": 0,
    "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/dtptite"
  },
  "_devurl": "https://github.com/icr-epat/dtptite",
  "_searchresults": 1,
  "_rbuild": "4.6.1",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/dtptite.html",
    "extra/manual.pdf",
    "extra/NEWS.html",
    "extra/NEWS.txt"
  ],
  "_cranurl": false,
  "_releases": [
    {
      "version": "0.1.0",
      "date": "2026-10-21"
    }
  ],
  "_exports": [
    "apply_dtp",
    "dtp_projected_dose",
    "dtp_should_wait",
    "dtp_wait_events",
    "dtp_wait_summary",
    "dtp_wait_time",
    "get_boin_tite",
    "scenario_mtd",
    "set_dtp_queue_size",
    "stop_for_beta_binomial_toxicity",
    "time_to_first_mtd",
    "tite_patient_samples"
  ],
  "_help": [
    {
      "page": "apply_dtp",
      "title": "Apply the DTP look-ahead to a TITE selector factory.",
      "topics": [
        "apply_dtp"
      ]
    },
    {
      "page": "dtp_projected_dose",
      "title": "Projected dose after waiting.",
      "topics": [
        "dtp_projected_dose"
      ]
    },
    {
      "page": "dtp_should_wait",
      "title": "Should the trialist wait before dosing the next cohort?",
      "topics": [
        "dtp_should_wait"
      ]
    },
    {
      "page": "dtp_wait_events",
      "title": "Raw DTP wait event log from simulated trials.",
      "topics": [
        "dtp_wait_events"
      ]
    },
    {
      "page": "dtp_wait_summary",
      "title": "Per-trial DTP wait summary from simulated trials.",
      "topics": [
        "dtp_wait_summary"
      ]
    },
    {
      "page": "dtp_wait_time",
      "title": "Minimum wait time before the dose recommendation changes.",
      "topics": [
        "dtp_wait_time"
      ]
    },
    {
      "page": "get_boin_tite",
      "title": "Create a TITE-BOIN dose-finding selector.",
      "topics": [
        "get_boin_tite"
      ]
    },
    {
      "page": "plot.time_to_first_mtd",
      "title": "Plot the cumulative incidence of reaching the MTD.",
      "topics": [
        "plot.time_to_first_mtd"
      ]
    },
    {
      "page": "scenario_mtd",
      "title": "True MTD of a simulated scenario.",
      "topics": [
        "scenario_mtd"
      ]
    },
    {
      "page": "set_dtp_queue_size",
      "title": "Set the waiting-room capacity for DTP simulation.",
      "topics": [
        "set_dtp_queue_size"
      ]
    },
    {
      "page": "stop_for_beta_binomial_toxicity",
      "title": "Stop for excessive toxicity using a Beta-Binomial conjugate posterior.",
      "topics": [
        "stop_for_beta_binomial_toxicity"
      ]
    },
    {
      "page": "summary.time_to_first_mtd",
      "title": "Summarise time-to-first-MTD across replicates.",
      "topics": [
        "summary.time_to_first_mtd"
      ]
    },
    {
      "page": "time_to_first_mtd",
      "title": "Time until the first patient is dosed at the true MTD.",
      "topics": [
        "time_to_first_mtd"
      ]
    },
    {
      "page": "tite_patient_samples",
      "title": "Create patient samples with realistic TITE DLT timing.",
      "topics": [
        "tite_patient_samples"
      ]
    }
  ],
  "_pkglogo": "https://github.com/cran/dtptite/raw/HEAD/man/figures/logo.svg",
  "_rundeps": [
    "abind",
    "arrayhelpers",
    "backports",
    "base64enc",
    "BH",
    "binom",
    "bit",
    "bit64",
    "BOIN",
    "brio",
    "bslib",
    "cachem",
    "callr",
    "checkmate",
    "cli",
    "clipr",
    "coda",
    "cpp11",
    "crayon",
    "desc",
    "dfcrm",
    "DiagrammeR",
    "diffobj",
    "digest",
    "distributional",
    "dplyr",
    "escalation",
    "evaluate",
    "farver",
    "fastmap",
    "fontawesome",
    "fs",
    "generics",
    "ggdist",
    "ggplot2",
    "glue",
    "gridExtra",
    "gtable",
    "gtools",
    "highr",
    "hms",
    "htmltools",
    "htmlwidgets",
    "igraph",
    "inline",
    "Iso",
    "isoband",
    "jquerylib",
    "jsonlite",
    "knitr",
    "labeling",
    "lattice",
    "lifecycle",
    "loo",
    "magrittr",
    "MASS",
    "Matrix",
    "matrixStats",
    "memoise",
    "mime",
    "mvtnorm",
    "numDeriv",
    "otel",
    "pillar",
    "pkgbuild",
    "pkgconfig",
    "pkgload",
    "posterior",
    "praise",
    "prettyunits",
    "processx",
    "progress",
    "ps",
    "purrr",
    "quadprog",
    "QuickJSR",
    "R6",
    "rappdirs",
    "RColorBrewer",
    "Rcpp",
    "RcppEigen",
    "RcppParallel",
    "readr",
    "rlang",
    "rmarkdown",
    "rprojroot",
    "rstan",
    "rstantools",
    "rstudioapi",
    "S7",
    "sass",
    "scales",
    "StanHeaders",
    "stringi",
    "stringr",
    "svUnit",
    "tensorA",
    "testthat",
    "tibble",
    "tidybayes",
    "tidyr",
    "tidyselect",
    "tinytex",
    "trialr",
    "tzdb",
    "utf8",
    "vctrs",
    "viridis",
    "viridisLite",
    "visNetwork",
    "vroom",
    "waldo",
    "withr",
    "xfun",
    "yaml"
  ],
  "_score": 1,
  "_indexed": false,
  "_nocasepkg": "dtptite",
  "_universes": [
    "cran",
    "xlai",
    "icr-epat"
  ],
  "_indexurl": "https://icr-epat.r-universe.dev/dtptite",
  "_binaries": [
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "0.1.0",
      "date": "2026-10-21T17:44:49.000Z",
      "distro": "resolute",
      "commit": "da91febff1fe9fa71ea703ec49b12c98cb0be1ef",
      "fileid": "https://r2.ropensci.org/e802d0f66f5a95587b963b881ccdfe496c90d01a1c1b3ce8bc9eb9cbf1ab6007",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/cran/actions/runs/39645610489"
    },
    {
      "r": "4.6.1",
      "os": "linux",
      "version": "0.1.0",
      "date": "2026-10-21T17:44:48.000Z",
      "distro": "resolute",
      "commit": "da91febff1fe9fa71ea703ec49b12c98cb0be1ef",
      "fileid": "https://r2.ropensci.org/1606f7b2c758020098bbf9c916062348ede6d6982080637bcf352eb9de9491c9",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/cran/actions/runs/39645610489"
    },
    {
      "r": "4.6.0",
      "os": "wasm",
      "version": "0.1.0",
      "date": "2026-10-21T17:44:54.000Z",
      "commit": "da91febff1fe9fa71ea703ec49b12c98cb0be1ef",
      "fileid": "https://r2.ropensci.org/ed417391db8396450ca58594cd35ad207439c0f0b76eaf7afd3b1d0981e173d7",
      "status": "success",
      "buildurl": "https://github.com/r-universe/cran/actions/runs/39645610489"
    },
    {
      "r": "4.7.0",
      "os": "win",
      "version": "0.1.0",
      "date": "2026-10-21T17:43:59.000Z",
      "commit": "da91febff1fe9fa71ea703ec49b12c98cb0be1ef",
      "fileid": "https://r2.ropensci.org/941934bab0da59403a48979ecff29055fa90d18c2b72c1a88d8c7c480ee531c8",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/cran/actions/runs/39645610489"
    },
    {
      "r": "4.6.1",
      "os": "win",
      "version": "0.1.0",
      "date": "2026-10-21T17:43:51.000Z",
      "commit": "da91febff1fe9fa71ea703ec49b12c98cb0be1ef",
      "fileid": "https://r2.ropensci.org/7931cf2765dd752ed606525861d04b1a46cdcd9d5532782beb4a309d0c0576c8",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/cran/actions/runs/39645610489"
    }
  ]
}