Package: admixr2 0.1.0
H. van de Beek
admixr2: Aggregate Data Modelling
Fit pharmacokinetic/pharmacodynamic (PK/PD) models to aggregate-level data (mean vector and covariance matrix per study) rather than individual-level data. Integrates with the 'nlmixr2'/'rxode2' ecosystem via three estimation methods: a First-Order ('FO') analytical estimator, a Monte Carlo (MC) estimator, and an Iterative Reweighting Monte Carlo ('IRMC') estimator. Methods are based on Välitalo (2021) <doi:10.1007/s10928-021-09760-1>; software described in van de Beek et al. (2025) <doi:10.1007/s10928-025-10011-w>.
Authors:
admixr2_0.1.0.tar.gz
admixr2_0.1.0.tar.gz(r-4.6-arm64)admixr2_0.1.0.tar.gz(r-4.6-x86_64)
admixr2_0.1.0.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
card.svg |card.png
admixr2/json (API)
NEWS
| # Install 'admixr2' in R: |
| install.packages('admixr2', repos = c('https://cran.r-universe.dev', 'https://cloud.r-project.org')) |
Bug tracker:https://github.com/leidenpharmacology/admixr2/issues
Pkgdown/docs site:https://leidenpharmacology.github.io
- examplomycin - Examplomycin dataset
Last updated from:6d80b7b2ba. Checks:2 FAIL, 4 OK. Indexed: no.
| Target | Result | Time | Files | Syslog |
|---|---|---|---|---|
| linux-devel-arm64 | FAIL | 174 | ||
| linux-devel-x86_64 | FAIL | 132 | ||
| source / vignettes | OK | 324 | ||
| linux-release-arm64 | OK | 263 | ||
| linux-release-x86_64 | OK | 266 | ||
| wasm-release | OK | 182 |
Exports:adfoControladirmcControladmControladmDataadmStopWorkersdatagendatagenControl
Dependencies:armadillo4rbackportsBHcachemcheckmateclicpp11cpp4rcrayondata.tabledescdigestdparserevaluatefarverfastmapggplot2gluegtablehighrinlineisobandknitrlabelinglatticelbfgsb3clifecyclelotriMatrixmemoiseminqan1qn1nlmenlmixr2datanlmixr2estnloptrnumDerivPreciseSumsqs2R6randtoolboxRColorBrewerRcppRcppArmadilloRcppEigenRcppParallelrexrlangrngWELLrxode2rxode2llS7scalessitmoStanHeadersstringfishsymenginesysvctrsviridisLitewithrxfunyaml
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| Control settings for the FO (First-Order) estimator | adfoControl |
| Control settings for the IRMC estimator | adirmcControl |
| Control settings for the ADM estimator | admControl |
| Dummy data frame for nlmixr2 dispatch | admData |
| Stop PSOCK workers | admStopWorkers |
| Generate aggregate study data from (possibly different) pharmacometric models | datagen |
| Control parameters for 'datagen()' | datagenControl |
| Examplomycin dataset | examplomycin |
| Fit an aggregate data model via First-Order (FO) approximation | nlmixr2Est.adfo |
| Fit an aggregate data model via Iterative Reweighting MC (adirmc estimator) | nlmixr2Est.adirmc |
| Fit an aggregate data model via Monte Carlo (admc estimator) | nlmixr2Est.admc |
| Diagnostic plots for an admixr2 fit | plot.admFit |
| Print method for admFit objects | print.admFit |