{ "_id": "6a211a4fcd65a98ecbd1d23e", "Package": "admixr2", "Type": "Package", "Title": "Aggregate Data Modelling", "Version": "0.1.0", "Authors@R": "c(\nperson(\"H.\", \"van de Beek\", email = \"h.van.de.beek@lacdr.leidenuniv.nl\", role = c(\"aut\", \"cre\")),\nperson(\"P.A.J.\", \"Välitalo\", role = \"aut\"),\nperson(\"L.B.\", \"Zwep\", role = \"aut\"),\nperson(\"J.G.C.\", \"van Hasselt\", role = \"aut\")\n)", "Description": "Fit pharmacokinetic/pharmacodynamic (PK/PD) models to\naggregate-level data (mean vector and covariance matrix per\nstudy) rather than individual-level data. Integrates with the\n'nlmixr2'/'rxode2' ecosystem via three estimation methods: a\nFirst-Order ('FO') analytical estimator, a Monte Carlo (MC)\nestimator, and an Iterative Reweighting Monte Carlo ('IRMC')\nestimator. Methods are based on Välitalo (2021)\n; software described in van de\nBeek et al. (2025) .", "License": "GPL (>= 3)", "URL": "https://leidenpharmacology.github.io/admixr2/,\nhttps://github.com/LeidenPharmacology/admixr2", "BugReports": "https://github.com/LeidenPharmacology/admixr2/issues", "Encoding": "UTF-8", "LazyData": "true", "RoxygenNote": "7.3.3", "VignetteBuilder": "knitr", "Config/testthat/edition": "3", "NeedsCompilation": "yes", "Packaged": { "Date": "2026-06-02 18:54:23 UTC", "User": "root" }, "Author": "H. van de Beek [aut, cre], P.A.J. Välitalo [aut], L.B. Zwep\n[aut], J.G.C. van Hasselt [aut]", "Maintainer": "H. van de Beek ", "Config/pak/sysreqs": "cmake libgmp3-dev make libmpfr-dev", "Repository": "https://cran.r-universe.dev", "Date/Publication": "2026-06-02 11:46:44 UTC", "RemoteUrl": "https://github.com/cran/admixr2", "RemoteRef": "HEAD", "RemoteSha": "6d80b7b2baa7694b386abe912124fe1841df1352", "MD5sum": "3b0963ae3f7c8d603656022f194d1cb7", "_user": "cran", "_type": "src", "_file": "admixr2_0.1.0.tar.gz", "_fileid": "056759175eb416ca7509cb6bb8d45c2bf85734fccac3ad2fe09a453685e06a9a", "_filesize": 611356, "_sha256": "056759175eb416ca7509cb6bb8d45c2bf85734fccac3ad2fe09a453685e06a9a", "_created": "2026-06-02T18:54:23.000Z", "_published": "2026-06-04T06:25:19.338Z", "_distro": "noble", "_jobs": [ { "job": 79461629531, "time": 174, "config": "linux-devel-arm64", "r": "4.7.0", "check": "FAIL", "artifact": "" }, { "job": 79461629580, "time": 132, "config": "linux-devel-x86_64", "r": "4.7.0", "check": "FAIL", "artifact": "" }, { "job": 79461630034, "time": 263, "config": "linux-release-arm64", "r": "4.6.0", "check": "OK", "artifact": "7367137766" }, { "job": 79461629909, "time": 266, "config": "linux-release-x86_64", "r": "4.6.0", "check": "OK", "artifact": "7367137737" }, { "job": 79461629549, "time": 324, "config": "source", "r": "4.6.0", "check": "OK", "artifact": "7367042452" }, { "job": 79461629692, "time": 182, "config": "wasm-release", "r": "4.6.0", "check": "OK", "artifact": "7367107768" } ], "_buildurl": "https://github.com/r-universe/cran/actions/runs/26840966913", "_status": "success", "_host": "GitHub-Actions", "_upstream": "https://github.com/cran/admixr2", "_commit": { "id": "6d80b7b2baa7694b386abe912124fe1841df1352", "author": "H. van de Beek ", "committer": "cran-robot ", "message": "version 0.1.0\n", "time": 1780400804 }, "_maintainer": { "name": "H. van de Beek", "email": "h.van.de.beek@lacdr.leidenuniv.nl" }, "_registered": true, "_dependencies": [ { "package": "R", "version": ">= 4.1.0", "role": "Depends" }, { "package": "Rcpp", "role": "LinkingTo" }, { "package": "RcppEigen", "role": "LinkingTo" }, { "package": "checkmate", "role": "Imports" }, { "package": "digest", "role": "Imports" }, { "package": "nlmixr2est", "role": "Imports" }, { "package": "nloptr", "role": "Imports" }, { "package": "qs2", "role": "Imports" }, { "package": "randtoolbox", "role": "Imports" }, { "package": "Rcpp", "role": "Imports" }, { "package": "rxode2", "role": "Imports" }, { "package": "expm", "role": "Suggests" }, { "package": "furrr", "role": "Suggests" }, { "package": "future", "role": "Suggests" }, { "package": "ggplot2", "role": "Suggests" }, { "package": "knitr", "role": "Suggests" }, { "package": "mnormt", "role": "Suggests" }, { "package": "nlmixr2", "role": "Suggests" }, { "package": "patchwork", "role": "Suggests" }, { "package": "rmarkdown", "role": "Suggests" }, { "package": "testthat", "version": ">= 3.0.0", "role": "Suggests" } ], "_owner": "cran", "_selfowned": false, "_usedby": 0, "_updates": [ { "week": "2026-23", "n": 1 } ], "_tags": [ { "name": "0.1.0", "date": "2026-06-02" } ], "_stars": 0, "_userbio": { "uuid": 6899542, "type": "organization", "name": "cran", "description": "Unofficial read-only mirror of all CRAN R packages" }, "_downloads": { "count": 0, "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/admixr2" }, "_devurl": "https://github.com/leidenpharmacology/admixr2", "_pkgdown": "https://leidenpharmacology.github.io/admixr2/", "_topics": [ "cpp" ], "_rbuild": "4.6.0", "_assets": [ "extra/admixr2.html", "extra/citation.cff", "extra/citation.html", "extra/citation.json", "extra/citation.txt", "extra/contents.json", "extra/NEWS.html", "extra/NEWS.txt", "extra/readme.html", "extra/readme.md", "manual.pdf" ], "_cranurl": false, "_releases": [ { "version": "0.1.0", "date": "2026-06-02" } ], "_exports": [ "adfoControl", "adirmcControl", "admControl", "admData", "admStopWorkers", "datagen", "datagenControl" ], "_datasets": [ { "name": "examplomycin", "title": "Examplomycin dataset", "object": "examplomycin", "class": [ "data.frame" ], "fields": [ "ID", "TIME", "DV", "AMT", "EVID", "CMT" ], "rows": 5000, "table": true, "tojson": true } ], "_help": [ { "page": "adfoControl", "title": "Control settings for the FO (First-Order) estimator", "topics": [ "adfoControl" ] }, { "page": "adirmcControl", "title": "Control settings for the IRMC estimator", "topics": [ "adirmcControl" ] }, { "page": "admControl", "title": "Control settings for the ADM estimator", "topics": [ "admControl" ] }, { "page": "admData", "title": "Dummy data frame for nlmixr2 dispatch", "topics": [ "admData" ] }, { "page": "admStopWorkers", "title": "Stop PSOCK workers", "topics": [ "admStopWorkers" ] }, { "page": "datagen", "title": "Generate aggregate study data from (possibly different) pharmacometric models", "topics": [ "datagen" ] }, { "page": "datagenControl", "title": "Control parameters for 'datagen()'", "topics": [ "datagenControl" ] }, { "page": "examplomycin", "title": "Examplomycin dataset", "topics": [ "examplomycin" ] }, { "page": "nlmixr2Est.adfo", "title": "Fit an aggregate data model via First-Order (FO) approximation", "topics": [ "nlmixr2Est.adfo" ] }, { "page": "nlmixr2Est.adirmc", "title": "Fit an aggregate data model via Iterative Reweighting MC (adirmc estimator)", "topics": [ "nlmixr2Est.adirmc" ] }, { "page": "nlmixr2Est.admc", "title": "Fit an aggregate data model via Monte Carlo (admc estimator)", "topics": [ "nlmixr2Est.admc" ] }, { "page": "plot.admFit", "title": "Diagnostic plots for an admixr2 fit", "topics": [ "plot.admFit" ] }, { "page": "print.admFit", "title": "Print method for admFit objects", "topics": [ "print.admFit" ] } ], "_pkglogo": "https://github.com/cran/admixr2/raw/HEAD/man/figures/logo.png", "_readme": "https://github.com/cran/admixr2/raw/HEAD/README.md", "_rundeps": [ "armadillo4r", "backports", "BH", "cachem", "checkmate", "cli", "cpp11", "cpp4r", "crayon", "data.table", "desc", "digest", "dparser", "evaluate", "farver", "fastmap", "ggplot2", "glue", "gtable", "highr", "inline", "isoband", "knitr", "labeling", "lattice", "lbfgsb3c", "lifecycle", "lotri", "Matrix", "memoise", "minqa", "n1qn1", "nlme", "nlmixr2data", "nlmixr2est", "nloptr", "numDeriv", "PreciseSums", "qs2", "R6", "randtoolbox", "RColorBrewer", "Rcpp", "RcppArmadillo", "RcppEigen", "RcppParallel", "rex", "rlang", "rngWELL", "rxode2", "rxode2ll", "S7", "scales", "sitmo", "StanHeaders", "stringfish", "symengine", "sys", "vctrs", "viridisLite", "withr", "xfun", "yaml" ], "_sysdeps": [ { "shlib": "libstdc++", "package": "libstdc++6", "source": "gcc", "version": "14.2.0-4ubuntu2~24.04.1", "name": "c++", "homepage": "http://gcc.gnu.org/", "description": "GNU Standard C++ Library v3" } ], "_vignettes": [ { "source": "admixr2.Rmd", "filename": "admixr2.html", "title": "Getting started with admixr2", "engine": "knitr::rmarkdown", "headings": [ "What is aggregate-data modelling?", "The examplomycin dataset", "Computing aggregate statistics", "Model definition", "Assembling the study specification", "Fitting", "Inspecting the fit", "Diagnostic plots" ], "created": "2026-06-02 11:46:44", "modified": "2026-06-02 11:46:44", "commits": 1 } ], "_score": 2.6989700043360187, "_indexed": false, "_nocasepkg": "admixr2", "_universes": [ "cran", "leidenpharmacology" ], "_indexurl": "https://leidenpharmacology.r-universe.dev/admixr2", "_binaries": [ { "r": "4.6.0", "os": "linux", "version": "0.1.0", "date": "2026-06-02T18:58:23.000Z", "distro": "noble", "arch": "aarch64", "commit": "6d80b7b2baa7694b386abe912124fe1841df1352", "fileid": "15c8d9f85e8df40c6942b55865d77dd69a1dde985a79fd0e93aae9be8f010764", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/cran/actions/runs/26840966913" }, { "r": "4.6.0", "os": "linux", "version": "0.1.0", "date": "2026-06-02T18:58:13.000Z", "distro": "noble", "arch": "x86_64", "commit": "6d80b7b2baa7694b386abe912124fe1841df1352", "fileid": "f9ae688e0765b728f1779652c197f31746fc4cea6cb5ac25c5f00ab90aff2ac6", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/cran/actions/runs/26840966913" }, { "r": "4.6.0", "os": "wasm", "version": "0.1.0", "date": "2026-06-02T18:57:47.000Z", "arch": "emscripten", "commit": "6d80b7b2baa7694b386abe912124fe1841df1352", "fileid": "7bd5782cd65eeb39d773955ef37bc39ff1b5476ef69b83e20374c1f1f61f834a", "status": "success", "buildurl": "https://github.com/r-universe/cran/actions/runs/26840966913" } ] }