Package: UnifiedDoseFinding 0.1.10
Chia-Wei Hsu
UnifiedDoseFinding: Dose-Finding Methods for Non-Binary Outcomes
In many phase I trials, the design goal is to find the dose associated with a certain target toxicity rate. In some trials, the goal can be to find the dose with a certain weighted sum of rates of various toxicity grades. For others, the goal is to find the dose with a certain mean value of a continuous response. This package provides the setup and calculations needed to run a dose-finding trial with non-binary endpoints and performs simulations to assess design’s operating characteristics under various scenarios. Three dose finding designs are included in this package: unified phase I design (Ivanova et al. (2009) <doi:10.1111/j.1541-0420.2008.01045.x>), Quasi-CRM/Robust-Quasi-CRM (Yuan et al. (2007) <doi:10.1111/j.1541-0420.2006.00666.x>, Pan et al. (2014) <doi:10.1371/journal.pone.0098147>) and generalized BOIN design (Mu et al. (2018) <doi:10.1111/rssc.12263>). The toxicity endpoints can be handled with these functions including equivalent toxicity score (ETS), total toxicity burden (TTB), general continuous toxicity endpoints, with incorporating ordinal grade toxicity information into dose-finding procedure. These functions allow customization of design characteristics to vary sample size, cohort sizes, target dose-limiting toxicity (DLT) rates, discrete or continuous toxicity score, and incorporate safety and/or stopping rules.
Authors:
UnifiedDoseFinding_0.1.10.tar.gz
UnifiedDoseFinding_0.1.10.tar.gz(r-4.5-noble)UnifiedDoseFinding_0.1.10.tar.gz(r-4.4-noble)
UnifiedDoseFinding_0.1.10.tgz(r-4.4-emscripten)UnifiedDoseFinding_0.1.10.tgz(r-4.3-emscripten)
UnifiedDoseFinding.pdf |UnifiedDoseFinding.html✨
UnifiedDoseFinding/json (API)
# Install 'UnifiedDoseFinding' in R: |
install.packages('UnifiedDoseFinding', repos = c('https://cran.r-universe.dev', 'https://cloud.r-project.org')) |
This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.
Last updated 2 years agofrom:8ea2ecfdd6. Checks:OK: 2. Indexed: yes.
Target | Result | Date |
---|---|---|
Doc / Vignettes | OK | Dec 16 2024 |
R-4.5-linux | OK | Dec 16 2024 |
Exports:get_oc_gBOIN_continuousget_oc_gBOIN_TBget_oc_Ivanova_binaryget_oc_Ivanova_continuousget_oc_QuasiBOINget_oc_RQ_CRMnext_gBOIN_continuousnext_gBOIN_TBnext_Ivanova_binarynext_Ivanova_continuousnext_QuasiBOINnext_RQ_CRMselect_mtd_gBOIN_continuousselect_mtd_gBOIN_TBselect_mtd_Ivanova_binaryselect_mtd_Ivanova_continuousselect_mtd_QuasiBOINselect_mtd_RQ_CRM
Dependencies: