{ "_id": "6ab25b573d719c1f8408c6f5", "Package": "UnifiedDoseFinding", "Type": "Package", "Title": "Dose-Finding Methods for Non-Binary Outcomes", "Version": "0.1.10", "Author": "Chia-Wei Hsu, Haitao Pan, Rongji Mu", "Maintainer": "Chia-Wei Hsu ", "Description": "In many phase I trials, the design goal is to find the\ndose associated with a certain target toxicity rate. In some\ntrials, the goal can be to find the dose with a certain\nweighted sum of rates of various toxicity grades. For others,\nthe goal is to find the dose with a certain mean value of a\ncontinuous response. This package provides the setup and\ncalculations needed to run a dose-finding trial with non-binary\nendpoints and performs simulations to assess design’s operating\ncharacteristics under various scenarios. Three dose finding\ndesigns are included in this package: unified phase I design\n(Ivanova et al. (2009) ),\nQuasi-CRM/Robust-Quasi-CRM (Yuan et al. (2007)\n, Pan et al. (2014)\n) and generalized BOIN design\n(Mu et al. (2018) ). The toxicity\nendpoints can be handled with these functions including\nequivalent toxicity score (ETS), total toxicity burden (TTB),\ngeneral continuous toxicity endpoints, with incorporating\nordinal grade toxicity information into dose-finding procedure.\nThese functions allow customization of design characteristics\nto vary sample size, cohort sizes, target dose-limiting\ntoxicity (DLT) rates, discrete or continuous toxicity score,\nand incorporate safety and/or stopping rules.", "License": "GPL-2", "Encoding": "UTF-8", "NeedsCompilation": "no", "Packaged": { "Date": "2026-09-22 10:38:58 UTC", "User": "root" }, "Repository": "https://cran.r-universe.dev", "Date/Publication": "2022-10-15 21:52:37 UTC", "RemoteUrl": "https://github.com/cran/UnifiedDoseFinding", "RemoteRef": "HEAD", "RemoteSha": "8ea2ecfdd64d960306dd1dea6f7e18f7160f71b4", "_user": "cran", "_type": "src", "_file": "UnifiedDoseFinding_0.1.10.tar.gz", "_fileid": 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