Package: HybridDesign 1.0
Heng Zhou
HybridDesign: Hybrid Design for Phase I Dose-Finding Studies
The Hybrid design is a combination of model-assisted design (e.g., the modified Toxicity Probability Interval design) with dose-toxicity model-based design for phase I dose-finding studies. The hybrid design controls the overdosing toxicity well and leads to a recommended dose closer to the true maximum tolerated dose (MTD) due to its ability to calibrate for an intermediate dose. More details can be found in Liao et al. 2022 <doi:10.1002/ijc.34203>.
Authors:
HybridDesign_1.0.tar.gz
HybridDesign_1.0.tar.gz(r-4.5-noble)HybridDesign_1.0.tar.gz(r-4.4-noble)
HybridDesign_1.0.tgz(r-4.4-emscripten)HybridDesign_1.0.tgz(r-4.3-emscripten)
HybridDesign.pdf |HybridDesign.html✨
HybridDesign/json (API)
| # Install 'HybridDesign' in R: |
| install.packages('HybridDesign', repos = c('https://cran.r-universe.dev', 'https://cloud.r-project.org')) |
This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.
Last updated 2 years agofrom:b65a1a2b36. Checks:OK: 2. Indexed: yes.
| Target | Result | Date |
|---|---|---|
| Doc / Vignettes | OK | Sep 13 2024 |
| R-4.5-linux | OK | Sep 13 2024 |
Exports:get_boundary_mtpiget_oc_hybridhybridhybrid_MTD_selection
Dependencies:latticeMASSMatrixpbapplyResourceSelectiontestit
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| Generate modified mTPI Design Decision Boundary | get_boundary_mtpi |
| Generate operating characteristics for single-agent dose-finding studies using the Hybrid design | get_oc_hybrid |
| Implement Hybrid design with real data | hybrid |
| Select the maximum tolerated dose (MTD) for single-agent dose-finding studies | hybrid_MTD_selection |