Package: HybridDesign 1.0
Heng Zhou
HybridDesign: Hybrid Design for Phase I Dose-Finding Studies
The Hybrid design is a combination of model-assisted design (e.g., the modified Toxicity Probability Interval design) with dose-toxicity model-based design for phase I dose-finding studies. The hybrid design controls the overdosing toxicity well and leads to a recommended dose closer to the true maximum tolerated dose (MTD) due to its ability to calibrate for an intermediate dose. More details can be found in Liao et al. 2022 <doi:10.1002/ijc.34203>.
Authors:
HybridDesign_1.0.tar.gz
HybridDesign_1.0.tar.gz(r-4.7-any)HybridDesign_1.0.tar.gz(r-4.6-any)
HybridDesign_1.0.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
card.svg |card.png
HybridDesign/json (API)
| # Install 'HybridDesign' in R: |
| install.packages('HybridDesign', repos = c('https://cran.r-universe.dev', 'https://cloud.r-project.org')) |
This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.
Last updated from:b65a1a2b36. Checks:4 OK. Indexed: yes.
| Target | Result | Time | Files | Syslog |
|---|---|---|---|---|
| linux-devel-x86_64 | OK | 101 | ||
| source / vignettes | OK | 166 | ||
| linux-release-x86_64 | OK | 118 | ||
| wasm-release | OK | 106 |
Exports:get_boundary_mtpiget_oc_hybridhybridhybrid_MTD_selection
Dependencies:latticeMASSMatrixpbapplyResourceSelectiontestit
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| Generate modified mTPI Design Decision Boundary | get_boundary_mtpi |
| Generate operating characteristics for single-agent dose-finding studies using the Hybrid design | get_oc_hybrid |
| Implement Hybrid design with real data | hybrid |
| Select the maximum tolerated dose (MTD) for single-agent dose-finding studies | hybrid_MTD_selection |