Package: HybridDesign 1.0

Heng Zhou

HybridDesign: Hybrid Design for Phase I Dose-Finding Studies

The Hybrid design is a combination of model-assisted design (e.g., the modified Toxicity Probability Interval design) with dose-toxicity model-based design for phase I dose-finding studies. The hybrid design controls the overdosing toxicity well and leads to a recommended dose closer to the true maximum tolerated dose (MTD) due to its ability to calibrate for an intermediate dose. More details can be found in Liao et al. 2022 <doi:10.1002/ijc.34203>.

Authors:Heng Zhou [aut, cre], Feng Zhou [aut], Jason Liao [aut]

HybridDesign_1.0.tar.gz
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HybridDesign.pdf |HybridDesign.html
HybridDesign/json (API)

# Install 'HybridDesign' in R:
install.packages('HybridDesign', repos = c('https://cran.r-universe.dev', 'https://cloud.r-project.org'))

Peer review:

This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.

1.00 score 159 downloads 4 exports 6 dependencies

Last updated 2 years agofrom:b65a1a2b36. Checks:OK: 2. Indexed: yes.

TargetResultDate
Doc / VignettesOKDec 12 2024
R-4.5-linuxOKDec 12 2024

Exports:get_boundary_mtpiget_oc_hybridhybridhybrid_MTD_selection

Dependencies:latticeMASSMatrixpbapplyResourceSelectiontestit