{
  "_id": "6ab62d7c99f7aa8c6aa2bc51",
  "Package": "HybridDesign",
  "Type": "Package",
  "Title": "Hybrid Design for Phase I Dose-Finding Studies",
  "Version": "1.0",
  "Authors@R": "c(person(given = \"Heng\",\nfamily = \"Zhou\",\nrole = c(\"aut\", \"cre\"),\nemail = \"heng.zhou@merck.com\"),\nperson(given = \"Feng\",\nfamily = \"Zhou\",\nrole = \"aut\"),\nperson(given = \"Jason\",\nfamily = \"Liao\",\nrole = \"aut\"))",
  "Maintainer": "Heng Zhou <heng.zhou@merck.com>",
  "Description": "The Hybrid design is a combination of model-assisted\ndesign (e.g., the modified Toxicity Probability Interval\ndesign) with dose-toxicity model-based design for phase I\ndose-finding studies. The hybrid design controls the overdosing\ntoxicity well and leads to a recommended dose closer to the\ntrue maximum tolerated dose (MTD) due to its ability to\ncalibrate for an intermediate dose. More details can be found\nin Liao et al. 2022 <doi:10.1002/ijc.34203>.",
  "License": "GPL-3",
  "Encoding": "UTF-8",
  "RoxygenNote": "7.1.2",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-09-25 08:12:02 UTC",
    "User": "root"
  },
  "Author": "Heng Zhou [aut, cre], Feng Zhou [aut], Jason Liao [aut]",
  "Repository": "https://cran.r-universe.dev",
  "Date/Publication": "2022-12-15 08:10:02 UTC",
  "RemoteUrl": "https://github.com/cran/HybridDesign",
  "RemoteRef": "HEAD",
  "RemoteSha": "b65a1a2b36ab27ed51a78a107198fb4b9d4dfe71",
  "_user": "cran",
  "_type": "src",
  "_file": "HybridDesign_1.0.tar.gz",
  "_fileid": "https://r2.ropensci.org/3712b2dea1aa8677c4e8f8c410a0c226f748fc014485740658d8632645880731",
  "_filesize": 96394,
  "_sha256": "3712b2dea1aa8677c4e8f8c410a0c226f748fc014485740658d8632645880731",
  "_expires": "2027-01-03T08:14:51.000Z",
  "_created": "2026-09-25T08:12:02.000Z",
  "_published": "2026-09-25T08:14:52.704Z",
  "_jobs": [
    {
      "job": 107996258089,
      "time": 125,
      "config": "linux-devel-x86_64",
      "r": "4.7.0",
      "check": "OK",
      "artifact": "10853476792"
    },
    {
      "job": 107996258129,
      "time": 122,
      "config": "linux-release-x86_64",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "10853536625"
    },
    {
      "job": 107995449225,
      "time": 167,
      "config": "source",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "10853083281"
    },
    {
      "job": 107996258194,
      "time": 115,
      "config": "wasm-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "10853103488"
    },
    {
      "job": 107996258182,
      "time": 74,
      "config": "windows-devel-x86_64",
      "r": "4.7.0",
      "check": "OK",
      "artifact": "10852953727"
    },
    {
      "job": 107996258108,
      "time": 74,
      "config": "windows-release-x86_64",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "10853636287"
    }
  ],
  "_host": "GitHub-Actions",
  "_buildurl": "https://github.com/r-universe/cran/actions/runs/36111357823",
  "_status": "success",
  "_upstream": "https://github.com/cran/HybridDesign",
  "_commit": {
    "id": "b65a1a2b36ab27ed51a78a107198fb4b9d4dfe71",
    "author": "Heng Zhou <heng.zhou@merck.com>",
    "committer": "cran-robot <csardi.gabor+cran@gmail.com>",
    "message": "version 1.0\n",
    "time": 1671091802
  },
  "_maintainer": {
    "name": "Heng Zhou",
    "email": "heng.zhou@merck.com"
  },
  "_distro": "resolute",
  "_registered": true,
  "_dependencies": [
    {
      "package": "R",
      "version": ">= 3.6",
      "role": "Depends"
    },
    {
      "package": "testit",
      "role": "Imports"
    },
    {
      "package": "ResourceSelection",
      "role": "Imports"
    }
  ],
  "_owner": "cran",
  "_selfowned": false,
  "_usedby": 0,
  "_updates": [],
  "_tags": [],
  "_stars": 0,
  "_userbio": {
    "uuid": 6899542,
    "type": "organization",
    "name": "cran",
    "followers": 630,
    "description": "Unofficial read-only mirror of all CRAN R packages"
  },
  "_downloads": {
    "count": 268,
    "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/HybridDesign"
  },
  "_searchresults": 0,
  "_rbuild": "4.6.1",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/HybridDesign.html",
    "extra/manual.pdf"
  ],
  "_realowner": "cran",
  "_cranurl": false,
  "_releases": [
    {
      "version": "1.0",
      "date": "2022-12-15"
    }
  ],
  "_exports": [
    "get_boundary_mtpi",
    "get_oc_hybrid",
    "hybrid",
    "hybrid_MTD_selection"
  ],
  "_help": [
    {
      "page": "get_boundary_mtpi",
      "title": "Generate modified mTPI Design Decision Boundary",
      "topics": [
        "get_boundary_mtpi"
      ]
    },
    {
      "page": "get_oc_hybrid",
      "title": "Generate operating characteristics for single-agent dose-finding studies using the Hybrid design",
      "topics": [
        "get_oc_hybrid"
      ]
    },
    {
      "page": "hybrid",
      "title": "Implement Hybrid design with real data",
      "topics": [
        "hybrid"
      ]
    },
    {
      "page": "hybrid_MTD_selection",
      "title": "Select the maximum tolerated dose (MTD) for single-agent dose-finding studies",
      "topics": [
        "hybrid_MTD_selection"
      ]
    }
  ],
  "_rundeps": [
    "lattice",
    "MASS",
    "Matrix",
    "pbapply",
    "ResourceSelection",
    "testit"
  ],
  "_score": 1,
  "_indexed": true,
  "_nocasepkg": "hybriddesign",
  "_universes": [
    "cran"
  ],
  "_binaries": [
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "1.0",
      "date": "2026-09-25T08:13:59.000Z",
      "distro": "resolute",
      "commit": "b65a1a2b36ab27ed51a78a107198fb4b9d4dfe71",
      "fileid": "https://r2.ropensci.org/0ea1bc16450b29ed368f22a7176c139c1b2fa9a32b681ad9e689346a43270ebe",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/cran/actions/runs/36111357823"
    },
    {
      "r": "4.6.1",
      "os": "linux",
      "version": "1.0",
      "date": "2026-09-25T08:13:56.000Z",
      "distro": "resolute",
      "commit": "b65a1a2b36ab27ed51a78a107198fb4b9d4dfe71",
      "fileid": "https://r2.ropensci.org/ef85cf0698e4c7e43a7ab110114fb4d8ea9a3d645fe348bc3ef8933edb3169eb",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/cran/actions/runs/36111357823"
    },
    {
      "r": "4.6.0",
      "os": "wasm",
      "version": "1.0",
      "date": "2026-09-25T08:14:12.000Z",
      "commit": "b65a1a2b36ab27ed51a78a107198fb4b9d4dfe71",
      "fileid": "https://r2.ropensci.org/6101db669fcbf5678be42db95b1c91c31599624e917bcae2dd9e43433e58f16f",
      "status": "success",
      "buildurl": "https://github.com/r-universe/cran/actions/runs/36111357823"
    },
    {
      "r": "4.7.0",
      "os": "win",
      "version": "1.0",
      "date": "2026-09-25T08:13:05.000Z",
      "commit": "b65a1a2b36ab27ed51a78a107198fb4b9d4dfe71",
      "fileid": "https://r2.ropensci.org/6e5ea10faff17eb84e0f0aed27bccb9144d60511ccaf1cac7f0423ba5dc3033d",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/cran/actions/runs/36111357823"
    },
    {
      "r": "4.6.1",
      "os": "win",
      "version": "1.0",
      "date": "2026-09-25T08:13:09.000Z",
      "commit": "b65a1a2b36ab27ed51a78a107198fb4b9d4dfe71",
      "fileid": "https://r2.ropensci.org/9da0569224d922343d4dcfe0a27caf3971b914d990917efc343837e9f8e45507",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/cran/actions/runs/36111357823"
    }
  ]
}