{
  "_id": "6a1174bfacfb0bcc41cf8944",
  "Package": "HybridDesign",
  "Type": "Package",
  "Title": "Hybrid Design for Phase I Dose-Finding Studies",
  "Version": "1.0",
  "Authors@R": "c(person(given = \"Heng\",\nfamily = \"Zhou\",\nrole = c(\"aut\", \"cre\"),\nemail = \"heng.zhou@merck.com\"),\nperson(given = \"Feng\",\nfamily = \"Zhou\",\nrole = \"aut\"),\nperson(given = \"Jason\",\nfamily = \"Liao\",\nrole = \"aut\"))",
  "Maintainer": "Heng Zhou <heng.zhou@merck.com>",
  "Description": "The Hybrid design is a combination of model-assisted\ndesign (e.g., the modified Toxicity Probability Interval\ndesign) with dose-toxicity model-based design for phase I\ndose-finding studies. The hybrid design controls the overdosing\ntoxicity well and leads to a recommended dose closer to the\ntrue maximum tolerated dose (MTD) due to its ability to\ncalibrate for an intermediate dose. More details can be found\nin Liao et al. 2022 <doi:10.1002/ijc.34203>.",
  "License": "GPL-3",
  "Encoding": "UTF-8",
  "RoxygenNote": "7.1.2",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-05-23 09:32:25 UTC",
    "User": "root"
  },
  "Author": "Heng Zhou [aut, cre], Feng Zhou [aut], Jason Liao [aut]",
  "Repository": "https://cran.r-universe.dev",
  "Date/Publication": "2022-12-15 08:10:02 UTC",
  "RemoteUrl": "https://github.com/cran/HybridDesign",
  "RemoteRef": "HEAD",
  "RemoteSha": "b65a1a2b36ab27ed51a78a107198fb4b9d4dfe71",
  "MD5sum": "1ac92913015121ddb059babba98345a7",
  "_user": "cran",
  "_type": "src",
  "_file": "HybridDesign_1.0.tar.gz",
  "_fileid": "7b8d809eae7a1844bc6beb6955b7e41f9e021563f0155c61b784b912f203fbb4",
  "_filesize": 95577,
  "_sha256": "7b8d809eae7a1844bc6beb6955b7e41f9e021563f0155c61b784b912f203fbb4",
  "_created": "2026-05-23T09:32:25.000Z",
  "_published": "2026-05-23T09:34:55.624Z",
  "_distro": "noble",
  "_jobs": [
    {
      "job": 77512573303,
      "time": 101,
      "config": "linux-devel-x86_64",
      "r": "4.7.0",
      "check": "OK",
      "artifact": "7175981224"
    },
    {
      "job": 77512573302,
      "time": 118,
      "config": "linux-release-x86_64",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7175982884"
    },
    {
      "job": 77512424135,
      "time": 166,
      "config": "source",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7175972018"
    },
    {
      "job": 77512573308,
      "time": 106,
      "config": "wasm-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7175981699"
    }
  ],
  "_buildurl": "https://github.com/r-universe/cran/actions/runs/26329220389",
  "_status": "success",
  "_host": "GitHub-Actions",
  "_upstream": "https://github.com/cran/HybridDesign",
  "_commit": {
    "id": "b65a1a2b36ab27ed51a78a107198fb4b9d4dfe71",
    "author": "Heng Zhou <heng.zhou@merck.com>",
    "committer": "cran-robot <csardi.gabor+cran@gmail.com>",
    "message": "version 1.0\n",
    "time": 1671091802
  },
  "_maintainer": {
    "name": "Heng Zhou",
    "email": "heng.zhou@merck.com"
  },
  "_registered": true,
  "_dependencies": [
    {
      "package": "R",
      "version": ">= 3.6",
      "role": "Depends"
    },
    {
      "package": "testit",
      "role": "Imports"
    },
    {
      "package": "ResourceSelection",
      "role": "Imports"
    }
  ],
  "_owner": "cran",
  "_selfowned": false,
  "_usedby": 0,
  "_updates": [],
  "_tags": [],
  "_stars": 0,
  "_userbio": {
    "uuid": 6899542,
    "type": "organization",
    "name": "cran",
    "description": "Unofficial read-only mirror of all CRAN R packages"
  },
  "_downloads": {
    "count": 238,
    "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/HybridDesign"
  },
  "_searchresults": 0,
  "_rbuild": "4.6.0",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/HybridDesign.html",
    "manual.pdf"
  ],
  "_realowner": "cran",
  "_cranurl": false,
  "_releases": [
    {
      "version": "1.0",
      "date": "2022-12-15"
    }
  ],
  "_exports": [
    "get_boundary_mtpi",
    "get_oc_hybrid",
    "hybrid",
    "hybrid_MTD_selection"
  ],
  "_help": [
    {
      "page": "get_boundary_mtpi",
      "title": "Generate modified mTPI Design Decision Boundary",
      "topics": [
        "get_boundary_mtpi"
      ]
    },
    {
      "page": "get_oc_hybrid",
      "title": "Generate operating characteristics for single-agent dose-finding studies using the Hybrid design",
      "topics": [
        "get_oc_hybrid"
      ]
    },
    {
      "page": "hybrid",
      "title": "Implement Hybrid design with real data",
      "topics": [
        "hybrid"
      ]
    },
    {
      "page": "hybrid_MTD_selection",
      "title": "Select the maximum tolerated dose (MTD) for single-agent dose-finding studies",
      "topics": [
        "hybrid_MTD_selection"
      ]
    }
  ],
  "_rundeps": [
    "lattice",
    "MASS",
    "Matrix",
    "pbapply",
    "ResourceSelection",
    "testit"
  ],
  "_score": 1,
  "_indexed": true,
  "_nocasepkg": "hybriddesign",
  "_universes": [
    "cran"
  ],
  "_binaries": [
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "1.0",
      "date": "2026-05-23T09:34:02.000Z",
      "distro": "noble",
      "commit": "b65a1a2b36ab27ed51a78a107198fb4b9d4dfe71",
      "fileid": "022dcf86ea4238f444b4d13cca5c123ed2bd4e7060008b191d0e56c686162e22",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/cran/actions/runs/26329220389"
    },
    {
      "r": "4.6.0",
      "os": "linux",
      "version": "1.0",
      "date": "2026-05-23T09:34:16.000Z",
      "distro": "noble",
      "commit": "b65a1a2b36ab27ed51a78a107198fb4b9d4dfe71",
      "fileid": "8212d13ece7b2092f250ba4f53b86c3439d543cad55664d052d98f379f2c3b2d",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/cran/actions/runs/26329220389"
    },
    {
      "r": "4.6.0",
      "os": "wasm",
      "version": "1.0",
      "date": "2026-05-23T09:34:29.000Z",
      "commit": "b65a1a2b36ab27ed51a78a107198fb4b9d4dfe71",
      "fileid": "1d4983583ea9a881cef763bf55d9032ea23db57fe42f312f23e584bf87f62880",
      "status": "success",
      "buildurl": "https://github.com/r-universe/cran/actions/runs/26329220389"
    }
  ]
}