Package: FIND 0.1.1

Yunxuan Zhang

FIND: Objective Comparison of Phase I Dose-Finding Designs

Generate decision tables and simulate operating characteristics for phase I dose-finding designs to enable objective comparison across methods. Supported designs include the traditional 3+3, Bayesian Optimal Interval (BOIN) (Liu and Yuan (2015) <doi:10.1158/1078-0432.CCR-14-1526>), modified Toxicity Probability Interval-2 (mTPI-2) (Guo et al. (2017) <doi:10.1002/sim.7185>), interval 3+3 (i3+3) (Liu et al. (2020) <doi:10.1177/0962280220939123>), and Generalized 3+3 (G3). Provides visualization tools for comparing decision rules and operating characteristics across multiple designs simultaneously.

Authors:Yuan Ji [aut], Yunxuan Zhang [aut, cre]

FIND_0.1.1.tar.gz
FIND_0.1.1.tar.gz(r-4.7-any)FIND_0.1.1.tar.gz(r-4.6-any)
FIND_0.1.1.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
DESCRIPTION |NEWS
card.svg |card.png
FIND/json (API)

# Install 'FIND' in R:

install.packages('FIND', repos = c('https://cran.r-universe.dev', 'https://cloud.r-project.org'))

On CRAN:

This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.

2.00 score 184 downloads 24 exports 26 dependencies

Last updated from:53c335381b. Checks:4 OK. Indexed: yes.

Target	Result	Time
linux-devel-x86_64	OK	123
source / vignettes	OK	571
linux-release-x86_64	OK	145
wasm-release	OK	111

Exports:decision_table design_3plus3 design_boin design_g3plus3 design_i3plus3 design_mtpi2 generate_decision_table generate_oc_plot get_decision get_decision_3plus3 get_decision_boin get_decision_g3plus3 get_decision_i3plus3 get_decision_mtpi2 load_true oc_plot run_sim_3plus3 run_sim_boin run_sim_g3plus3 run_sim_i3plus3 run_sim_mtpi2 run_simulation select_mtd summarize_metric

Dependencies:cli cpp11 dplyr farver generics ggplot2 glue gridExtra gtable isoband labeling lifecycle magrittr pillar pkgconfig R6 RColorBrewer rlang S7 scales tibble tidyselect utf8 vctrs viridisLite withr

FIND Package Guidance

Rendered fromFIND_guidance.Rmdusingknitr::rmarkdown

Last update: 2025-12-15
Started: 2025-12-15

Help page	Topics
Generate Decision Tables with S3 Support	decision_table
Design Constructor Functions	design_3plus3 design_boin design_constructors design_g3plus3 design_i3plus3 design_mtpi2
Generate the decision table(s) for a single or multiple designs	generate_decision_table
Generate the plot(s) displaying operating characteristics for a single or multiple designs	generate_oc_plot
Generate Decision Tables for Phase I Dose-Finding Designs	get_decision get_decision.boin_design get_decision.default get_decision.g3plus3_design get_decision.i3plus3_design get_decision.mtpi2_design get_decision.threethree_design
Dosing decision for the 3+3 design	get_decision_3plus3
Dosing decision for the BOIN design	get_decision_boin
Dosing decision for the G3 design	get_decision_g3plus3
Dosing decision for the i3+3 design	get_decision_i3plus3
Dosing decision for the mTPI2 design	get_decision_mtpi2
Load several commonly used scenarios	load_true
Generate Operating Characteristics Plots with S3 Support	oc_plot
Simulations for the 3+3 design.	run_sim_3plus3
Simulations for the BOIN design.	run_sim_boin
Simulations for the G3 design.	run_sim_g3plus3
Simulations for the i3+3 design.	run_sim_i3plus3
Simulations for the mTPI2 design.	run_sim_mtpi2
Run Simulations for Phase I Dose-Finding Designs	run_simulation run_simulation.boin_design run_simulation.default run_simulation.g3plus3_design run_simulation.i3plus3_design run_simulation.mtpi2_design run_simulation.threethree_design
Select the maximum tolerated dose (MTD) using isotonic regression	select_mtd
Summarize after conducting simulations	summarize_metric

Package: FIND 0.1.1

FIND: Objective Comparison of Phase I Dose-Finding Designs

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