Package: DACT 1.0.0

Ping Gao

DACT: Design and Analysis for Clinical Trials

The applications and evaluation of the operating characteristics of many statistical methodologies require the use of sophisticated software or extensive simulations. 'DACT' is designed to serve a wide range of innovative statistical designs and analyses. The primary objective of the 'DACT' software is to promote the understanding and application of cutting-edge statistical solutions in clinical trials. For this reason, the software is free for non-commercial scientific research, including but not limited to academic researchers and research/teaching institutions. Computing codes are available upon request. For more details see P. Gao (2024) <doi:10.1080/10543406.2024.2341673>. Gao, P., Zhang, W. (2024) <doi:10.1080/10543406.2024.2358796>. P. Gao & Y. Li (2024) <doi:10.1080/10543406.2023.2233590>. P. Gao, Y. Li (2024) <doi:10.1080/10543406.2024.2342518>. Gao, P., L. Liu, and C. Mehta. (2013) <doi:10.1002/sim.5847>.

Authors:Ping Gao [aut, cre]

DACT_1.0.0.tar.gz
DACT_1.0.0.zip(r-4.7-any)DACT_1.0.0.zip(r-4.6-any)
DACT_1.0.0.tar.gz(r-4.7-any)DACT_1.0.0.tar.gz(r-4.6-any)
DACT_1.0.0.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
DESCRIPTION
card.svg |card.png
DACT/json (API)

# Install 'DACT' in R:
install.packages('DACT', repos = c('https://cran.r-universe.dev', 'https://cloud.r-project.org'))

Bug tracker:https://github.com/innovatiostat/rcode/issues

On CRAN:

Conda:

1.30 score 89 downloads 211 exports 26 dependencies

Last updated from:8a5bf927c6. Checks:6 OK. Indexed: yes.

TargetResultTimeFilesSyslog
linux-develOK223
source / vignettesOK212
linux-releaseOK239
windows-develOK210
windows-releaseOK213
wasm-releaseOK121

Exports:asd_ci_est_backasd_ci_est_one_arm_2_stageasd_ci_est_one_arm_3_stageasd_new_designasd_new_design_survivalasd_new_design_thetaasd_new_design_theta_survivalasd_power_simu_binaryasd_power_simu_neg_binomialasd_power_simu_normalasd_power_simu_poissonasd_power_simu_survivalasd_simu_OC_binaryasd_simu_OC_neg_binomialasd_simu_OC_normalasd_simu_OC_poissonasd_simu_OC_survivalEXP_3_stg_szfixed_rej_nbglm_simufixed_rej_rate_binaryfixed_rej_rate_normalfixed_rej_rate_poissonfixed_rej_rate_surv_coxgsd_ci_estgsd_ci_est_2_stagegsd_ci_est_3_stagegsd_power_simu_binarygsd_power_simu_negbinomgsd_power_simu_normalgsd_power_simu_poissongsd_power_simu_survivalhybrid_fixed_prior_rej_binary_simuhybrid_fixed_prior_rej_negbinom_simuhybrid_fixed_prior_rej_normal_simuhybrid_fixed_prior_rej_poisson_simuhybrid_fixed_prior_rej_survival_simuhybrid_random_prior_rej_binary_simuhybrid_random_prior_rej_negbinom_simuhybrid_random_prior_rej_normal_simuhybrid_random_prior_rej_poisson_simuhybrid_random_prior_rej_survival_simuhybrid_szinterim_analysismasd_est_back_no_dropmasd_est_back_with_dropmasd_est_cimasd_new_samszmasd_new_samsz_survivalmasd_new_samsz_thetamasd_new_samsz_theta_survivalmasd_power_simu_adapt_binarymasd_power_simu_adapt_neg_binomialmasd_power_simu_adapt_normalmasd_power_simu_adapt_poissonmasd_power_simu_adapt_survivalmasd_simu_OC_binarymasd_simu_OC_neg_binomialmasd_simu_OC_normalmasd_simu_OC_poissonmasd_simu_OC_survivalmidpnt_szMSD_power_alsp_boundary_binary_diffMSD_power_alsp_boundary_neg_binomialMSD_power_alsp_boundary_normalMSD_power_alsp_boundary_poissonMSD_power_alsp_boundary_survival_SchoenfeldMSD_power_OF_boundary_binary_diffMSD_power_OF_boundary_neg_binomialMSD_power_OF_boundary_normalMSD_power_OF_boundary_poissonMSD_power_OF_boundary_survival_Schoenfeldmsd_power_simu_binarymsd_power_simu_neg_binomialmsd_power_simu_normalmsd_power_simu_poissonmsd_power_simu_survivalMSD_Sample_size_alsp_boundary_binary_diffMSD_Sample_size_alsp_boundary_neg_binomialMSD_Sample_size_alsp_boundary_normalMSD_Sample_size_alsp_boundary_poissonMSD_Sample_size_alsp_boundary_survival_SchoenfeldMSD_Sample_size_OF_boundary_binary_diffMSD_Sample_size_OF_boundary_neg_binomialMSD_Sample_size_OF_boundary_normalMSD_Sample_size_OF_boundary_poissonMSD_Sample_size_OF_boundary_survival_Schoenfeldnew_sample_size_hybridone_arm_ad_3_stg_binaryone_arm_ad_two_stg_binaryone_arm_rej_2_stg_binaryone_arm_rej_3_stg_binaryone_arm_rej_simon_binarypower_alsp_boundary_binary_diffpower_alsp_boundary_binary_diff_NIpower_alsp_boundary_neg_binomialpower_alsp_boundary_neg_binomial_NIpower_alsp_boundary_normalpower_alsp_boundary_normal_NIpower_alsp_boundary_poissonpower_alsp_boundary_poisson_NIpower_alsp_boundary_survival_Schoenfeldpower_alsp_boundary_survival_Schoenfeld_NIpower_binary_diffpower_binary_diff_NIpower_OF_boundary_binary_diffpower_OF_boundary_binary_diff_NIpower_OF_boundary_neg_binomialpower_OF_boundary_neg_binomial_NIpower_OF_boundary_normalpower_OF_boundary_normal_NIpower_OF_boundary_poissonpower_OF_boundary_poisson_NIpower_OF_boundary_survival_Schoenfeldpower_OF_boundary_survival_Schoenfeld_NIpower_pocock_boundary_binary_diffpower_pocock_boundary_binary_diff_NIpower_pocock_boundary_neg_binomialpower_pocock_boundary_neg_binomial_NIpower_pocock_boundary_normalpower_pocock_boundary_normal_NIpower_pocock_boundary_poissonpower_pocock_boundary_poisson_NIpower_pocock_boundary_survival_Schoenfeldpower_pocock_boundary_survival_Schoenfeld_NIpower_two_sample_neg_binomialpower_two_sample_neg_binomial_NIpower_two_sample_normalpower_two_sample_normal_NIpower_two_sample_Poissonpower_two_sample_Poisson_NIpower_two_sample_surv_Schoenfeldpower_two_sample_surv_Schoenfeld_NISample_size_alsp_boundary_binary_diffSample_size_alsp_boundary_binary_diff_NISample_size_alsp_boundary_neg_binomialSample_size_alsp_boundary_neg_binomial_NISample_size_alsp_boundary_normalSample_size_alsp_boundary_normal_NISample_size_alsp_boundary_poissonSample_size_alsp_boundary_poisson_NISample_size_alsp_boundary_survival_SchoenfeldSample_size_alsp_boundary_survival_Schoenfeld_NIsample_size_binary_diffsample_size_binary_diff_NIsample_size_neg_binomialsample_size_neg_binomial_NISample_size_OF_boundary_binary_diffSample_size_OF_boundary_binary_diff_NISample_size_OF_boundary_neg_binomialSample_size_OF_boundary_neg_binomial_NISample_size_OF_boundary_normalSample_size_OF_boundary_normal_NISample_size_OF_boundary_poissonSample_size_OF_boundary_poisson_NISample_size_OF_boundary_survival_SchoenfeldSample_size_OF_boundary_survival_Schoenfeld_NISample_size_pocock_boundary_binary_diffSample_size_pocock_boundary_binary_diff_NISample_size_pocock_boundary_neg_binomialSample_size_pocock_boundary_neg_binomial_NISample_size_pocock_boundary_normalSample_size_pocock_boundary_normal_NISample_size_pocock_boundary_poissonSample_size_pocock_boundary_poisson_NISample_size_pocock_boundary_survival_SchoenfeldSample_size_pocock_boundary_survival_Schoenfeld_NIsample_size_two_sample_normalsample_size_two_sample_normal_NIsample_size_two_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Dependencies:cliclinfuncodetoolsdoParalleldplyrforeachgenericsglueiteratorsjsonlitelatticelifecyclemagrittrMASSMatrixmvtnormpillarpkgconfigR6rlangsurvivaltibbletidyselectutf8vctrswithr

Readme and manuals

Help Manual

Help pageTopics
Group sequential designs / Adaptive sequential designs: Final analysis, With one sample size changeasd_ci_est_back
Final analysis: two stage design, with sample size changeasd_ci_est_one_arm_2_stage
Final analysis: three stage design, with sample size changeasd_ci_est_one_arm_3_stage
Group sequential designs / Adaptive sequential designs: Interim analysis, Non-survival analysis, Use theta_interimasd_new_design
Group sequential designs / Adaptive sequential designs: Interim analysis, Survival analysis, Use theta_interimasd_new_design_survival
Group sequential designs / Adaptive sequential designs: Interim analysis, Non-survival analysis, Input thetaasd_new_design_theta
Group sequential designs / Adaptive sequential designs: Interim analysis, Survival analysis, Input thetaasd_new_design_theta_survival
Group sequential designs / Adaptive sequential designs: Simulations, Binary distribution, Operating characteristicsasd_power_simu_binary
Group sequential designs / Adaptive sequential designs: Simulations, Negative binomial distribution, Operating characteristicsasd_power_simu_neg_binomial
Group sequential designs / Adaptive sequential designs: Simulations, Normal distribution, Operating characteristicsasd_power_simu_normal
Group sequential designs / Adaptive sequential designs: Simulations, Poisson distribution, Operating characteristicsasd_power_simu_poisson
Group sequential designs / Adaptive sequential designs: Simulations, Survival analysis, Operating characteristicsasd_power_simu_survival
Group sequential designs / Adaptive sequential designs: Simulations, Binary distribution, Optimizing adaptive sequential designasd_simu_OC_binary
Group sequential designs / Adaptive sequential designs: Simulations, Negative binomial distribution, Optimizing adaptive sequential designasd_simu_OC_neg_binomial
Group sequential designs / Adaptive sequential designs: Simulations, Normal distribution, Optimizing adaptive sequential designasd_simu_OC_normal
Group sequential designs / Adaptive sequential designs: Simulations, Poisson distribution, Optimizing adaptive sequential designasd_simu_OC_poisson
Group sequential designs / Adaptive sequential designs: Simulations, Survival analysis, Optimizing adaptive sequential designasd_simu_OC_survival
Three-stage designEXP_3_stg_sz
Fixed sample designs: Negative binomial distribution, Simulationsfixed_rej_nbglm_simu
Fixed sample designs: Binary distribution, Simulationsfixed_rej_rate_binary
Fixed sample designs: Normal distribution, Simulationsfixed_rej_rate_normal
Fixed sample designs: Poisson distribution, Simulationsfixed_rej_rate_poisson
Fixed sample designs: Survival analysis, Simulationsfixed_rej_rate_surv_cox
Group sequential designs / Adaptive sequential designs: Final analysis, Without sample size changegsd_ci_est
Final analysis: two stage design, no sample size changegsd_ci_est_2_stage
Final analysis: three stage design, no sample size changegsd_ci_est_3_stage
Group sequential designs / Adaptive sequential designs: Simulations, Binary distribution, Type I error and powergsd_power_simu_binary
Group sequential designs / Adaptive sequential designs: Simulations, Negative binomial distribution, Type I error and powergsd_power_simu_negbinom
Group sequential designs / Adaptive sequential designs: Simulations, Normal distribution, Type I error and powergsd_power_simu_normal
Group sequential designs / Adaptive sequential designs: Simulations, Poisson distribution, Type I error and powergsd_power_simu_poisson
Group sequential designs / Adaptive sequential designs: Simulations, Survival analysis, Type I error and powergsd_power_simu_survival
Hybrid: Simulations, Binary distribution, Using given estimates of informative priorhybrid_fixed_prior_rej_binary_simu
Hybrid: Simulations, Negative binomial distribution, Using given estimates of informative priorhybrid_fixed_prior_rej_negbinom_simu
Hybrid: Simulations, Normal distribution, Using given estimates of informative priorhybrid_fixed_prior_rej_normal_simu
Hybrid: Simulations, Poisson distribution, Using given estimates of informative priorhybrid_fixed_prior_rej_poisson_simu
Hybrid: Simulations, Survival analysis, Using given estimates of informative priorhybrid_fixed_prior_rej_survival_simu
Hybrid: Simulations, Binary distribution, Using random informative prior from previous trialhybrid_random_prior_rej_binary_simu
Hybrid: Simulations, Negative binomial distribution, Using random informative prior from previous trialhybrid_random_prior_rej_negbinom_simu
Hybrid: Simulations, Normal distribution, Using random informative prior from previous trialhybrid_random_prior_rej_normal_simu
Hybrid: Simulations, Poisson distribution, Using random informative prior from previous trialhybrid_random_prior_rej_poisson_simu
Hybrid: Simulations, Survival analysis, Using random informative prior from previous trialhybrid_random_prior_rej_survival_simu
Two-stage design: the hybrid designhybrid_sz
The interim analysis can be conducted for both two-stage and three-stage designsinterim_analysis
Multiple comparisons Group sequential design: Final analysis, With one sample size change, orgin_comp==comp2masd_est_back_no_drop
Multiple comparisons Group sequential design: Final analysis, With one sample size change, orgin_comp>comp2masd_est_back_with_drop
Multiple comparisons Group sequential design: Final analysis, Without sample size changemasd_est_ci
Multiple comparisons Group sequential design: Interim analysis, Non-survival analysis, Use theta_interimmasd_new_samsz
Multiple comparisons Group sequential design: Interim analysis, Survival analysis, Use theta_interimmasd_new_samsz_survival
Multiple comparisons Group sequential design: Interim analysis, Non-survival analysis, Input thetamasd_new_samsz_theta
Multiple comparisons Group sequential design: Interim analysis, Survival analysis, Input thetamasd_new_samsz_theta_survival
Multiple comparisons Group sequential design: Simulations, Binary distribution, Operating characteristicsmasd_power_simu_adapt_binary
Multiple comparisons Group sequential design: Simulations, Negative binomial distribution, Operating characteristicsmasd_power_simu_adapt_neg_binomial
Multiple comparisons Group sequential design: Simulations, Normal distribution, Operating characteristicsmasd_power_simu_adapt_normal
Multiple comparisons Group sequential design: Simulations, Poisson distribution, Operating characteristicsmasd_power_simu_adapt_poisson
Multiple comparisons Group sequential design: Simulations, Survival analysis, Operating characteristicsmasd_power_simu_adapt_survival
Multiple comparisons Group sequential design: Simulations, Binary distribution, Optimizing adaptive sequential designmasd_simu_OC_binary
Multiple comparisons Group sequential design: Simulations, Negative binomial distribution, Optimizing adaptive sequential designmasd_simu_OC_neg_binomial
Multiple comparisons Group sequential design: Simulations, Normal distribution, Optimizing adaptive sequential designmasd_simu_OC_normal
Multiple comparisons Group sequential design: Simulations, Poisson distribution, Optimizing adaptive sequential designmasd_simu_OC_poisson
Multiple comparisons Group sequential design: Simulations, Survival analysis, Optimizing adaptive sequential designmasd_simu_OC_survival
Two-stage design: the midpoint designmidpnt_sz
Multiple comparisons Group sequential design: Binary distribution, Power calculation, Alpha-spending boundaryMSD_power_alsp_boundary_binary_diff
Multiple comparisons Group sequential design: Negative binomial distribution, Power calculation, Alpha-spending boundaryMSD_power_alsp_boundary_neg_binomial
Multiple comparisons Group sequential design: Normal distribution, Power calculation, Alpha-spending boundaryMSD_power_alsp_boundary_normal
Multiple comparisons Group sequential design: Poisson distribution, Power calculation, Alpha-spending boundaryMSD_power_alsp_boundary_poisson
Multiple comparisons Group sequential design: Survival analysis, Power calculation, Alpha-spending boundaryMSD_power_alsp_boundary_survival_Schoenfeld
Multiple comparisons Group sequential design: Binary distribution, Power calculation, O'Brien-Fleming boundaryMSD_power_OF_boundary_binary_diff
Multiple comparisons Group sequential design: Negative binomial distribution, Power calculation, O'Brien-Fleming boundaryMSD_power_OF_boundary_neg_binomial
Multiple comparisons Group sequential design: Normal distribution, Power calculation, O'Brien-Fleming boundaryMSD_power_OF_boundary_normal
Multiple comparisons Group sequential design: Poisson distribution, Power calculation, O'Brien-Fleming boundaryMSD_power_OF_boundary_poisson
Multiple comparisons Group sequential design: Survival analysis, Power calculation, O'Brien-Fleming boundaryMSD_power_OF_boundary_survival_Schoenfeld
Multiple comparisons Group sequential design: Simulations, Binary distribution, Type I error and powermsd_power_simu_binary
Multiple comparisons Group sequential design: Simulations, Negative binomial distribution, Type I error and powermsd_power_simu_neg_binomial
Multiple comparisons Group sequential design: Simulations, Normal distribution, Type I error and powermsd_power_simu_normal
Multiple comparisons Group sequential design: Simulations, Poisson distribution, Type I error and powermsd_power_simu_poisson
Multiple comparisons Group sequential design: Simulations, Survival analysis, Type I error and powermsd_power_simu_survival
Multiple comparisons Group sequential design: Binary distribution, Sample size calculation, Alpha-spending boundaryMSD_Sample_size_alsp_boundary_binary_diff
Multiple comparisons Group sequential design: Negative binomial distribution, Sample size calculation, Alpha-spending boundaryMSD_Sample_size_alsp_boundary_neg_binomial
Multiple comparisons Group sequential design: Normal distribution, Sample size calculation, Alpha-spending boundaryMSD_Sample_size_alsp_boundary_normal
Multiple comparisons Group sequential design: Poisson distribution, Sample size calculation, Alpha-spending boundaryMSD_Sample_size_alsp_boundary_poisson
Multiple comparisons Group sequential design: Survival analysis, Sample size calculation, Alpha-spending boundaryMSD_Sample_size_alsp_boundary_survival_Schoenfeld
Multiple comparisons Group sequential design: Binary distribution, Sample size calculation, O'Brien-Fleming boundaryMSD_Sample_size_OF_boundary_binary_diff
Multiple comparisons Group sequential design: Negative binomial distribution, Sample size calculation, O'Brien-Fleming boundaryMSD_Sample_size_OF_boundary_neg_binomial
Multiple comparisons Group sequential design: Normal distribution, Sample size calculation, O'Brien-Fleming boundaryMSD_Sample_size_OF_boundary_normal
Multiple comparisons Group sequential design: Poisson distribution, Sample size calculation, O'Brien-Fleming boundaryMSD_Sample_size_OF_boundary_poisson
Multiple comparisons Group sequential design: Survival analysis, Sample size calculation, O'Brien-Fleming boundaryMSD_Sample_size_OF_boundary_survival_Schoenfeld
Hybrid: New sample size estimationnew_sample_size_hybrid
Simulations: adaptive three stage designone_arm_ad_3_stg_binary
Simulations: adaptive two stage designone_arm_ad_two_stg_binary
Simulations: Two stage fixed expanded Simon's design: either hybrid or mid-point designone_arm_rej_2_stg_binary
Simulations: Expanded Simon's design: the three stage design, no sample size changeone_arm_rej_3_stg_binary
Simulations: two stage fixed Simon's designone_arm_rej_simon_binary
Group sequential designs / Adaptive sequential designs: Binary distribution, Superiority trial, Power calculation, Alpha-spending boundarypower_alsp_boundary_binary_diff
Group sequential designs / Adaptive sequential designs: Binary distribution, Non-inferiority trial, Power calculation, Alpha-spending boundarypower_alsp_boundary_binary_diff_NI
Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Superiority trial, Power calculation, Alpha-spending boundarypower_alsp_boundary_neg_binomial
Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Non-inferiority trial, Power calculation, Alpha-spending boundarypower_alsp_boundary_neg_binomial_NI
Group sequential designs / Adaptive sequential designs: Normal distribution, Superiority trial, Power calculation, Alpha-spending boundarypower_alsp_boundary_normal
Group sequential designs / Adaptive sequential designs: Normal distribution, Non-inferiority trial, Power calculation, Alpha-spending boundarypower_alsp_boundary_normal_NI
Group sequential designs / Adaptive sequential designs: Poisson distribution, Superiority trial, Power calculation, Alpha-spending boundarypower_alsp_boundary_poisson
Group sequential designs / Adaptive sequential designs: Poisson distribution, Non-inferiority trial, Power calculation, Alpha-spending boundarypower_alsp_boundary_poisson_NI
Group sequential designs / Adaptive sequential designs: Survival analysis, Superiority trial, Power calculation, Alpha-spending boundarypower_alsp_boundary_survival_Schoenfeld
Group sequential designs / Adaptive sequential designs: Survival analysis, Non-inferiority trial, Power calculation, Alpha-spending boundarypower_alsp_boundary_survival_Schoenfeld_NI
Fixed sample designs: Binary distribution, Superiority trial, Power calculationpower_binary_diff
Fixed sample designs: Binary distribution, Non-inferiority trial, Power calculationpower_binary_diff_NI
Group sequential designs / Adaptive sequential designs: Binary distribution, Superiority trial, Power calculation, O'Brien-Fleming boundarypower_OF_boundary_binary_diff
Group sequential designs / Adaptive sequential designs: Binary distribution, Non-inferiority trial, Power calculation, O'Brien-Fleming boundarypower_OF_boundary_binary_diff_NI
Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Superiority trial, Power calculation, O'Brien-Fleming boundarypower_OF_boundary_neg_binomial
Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Non-inferiority trial, Power calculation, O'Brien-Fleming boundarypower_OF_boundary_neg_binomial_NI
Group sequential designs / Adaptive sequential designs: Normal distribution, Superiority trial, Power calculation, O'Brien-Fleming boundarypower_OF_boundary_normal
Group sequential designs / Adaptive sequential designs: Normal distribution, Non-inferiority trial, Power calculation, O'Brien-Fleming boundarypower_OF_boundary_normal_NI
Group sequential designs / Adaptive sequential designs: Poisson distribution, Superiority trial, Power calculation, O'Brien-Fleming boundarypower_OF_boundary_poisson
Group sequential designs / Adaptive sequential designs: Poisson distribution, Non-inferiority trial, Power calculation, O'Brien-Fleming boundarypower_OF_boundary_poisson_NI
Group sequential designs / Adaptive sequential designs: Survival analysis, Superiority trial, Power calculation, O'Brien-Fleming boundarypower_OF_boundary_survival_Schoenfeld
Group sequential designs / Adaptive sequential designs: Survival analysis, Non-inferiority trial, Power calculation, O'Brien-Fleming boundarypower_OF_boundary_survival_Schoenfeld_NI
Group sequential designs / Adaptive sequential designs: Binary distribution, Superiority trial, Power calculation, Pocock boundarypower_pocock_boundary_binary_diff
Group sequential designs / Adaptive sequential designs: Binary distribution, Non-inferiority trial, Power calculation, Pocock boundarypower_pocock_boundary_binary_diff_NI
Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Superiority trial, Power calculation, Pocock boundarypower_pocock_boundary_neg_binomial
Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Non-inferiority trial, Power calculation, Pocock boundarypower_pocock_boundary_neg_binomial_NI
Group sequential designs / Adaptive sequential designs: Normal distribution, Superiority trial, Power calculation, Pocock boundarypower_pocock_boundary_normal
Group sequential designs / Adaptive sequential designs: Normal distribution, Non-inferiority trial, Power calculation, Pocock boundarypower_pocock_boundary_normal_NI
Group sequential designs / Adaptive sequential designs: Poisson distribution, Superiority trial, Power calculation, Pocock boundarypower_pocock_boundary_poisson
Group sequential designs / Adaptive sequential designs: Poisson distribution, Non-inferiority trial, Power calculation, Pocock boundarypower_pocock_boundary_poisson_NI
Group sequential designs / Adaptive sequential designs: Survival analysis, Superiority trial, Power calculation, Pocock boundarypower_pocock_boundary_survival_Schoenfeld
Group sequential designs / Adaptive sequential designs: Survival analysis, Non-inferiority trial, Power calculation, Pocock boundarypower_pocock_boundary_survival_Schoenfeld_NI
Fixed sample designs: Negative binomial distribution, Superiority trial, Power calculationpower_two_sample_neg_binomial
Fixed sample designs: Negative binomial distribution, Non-inferiority trial, Power calculationpower_two_sample_neg_binomial_NI
Fixed sample designs: Normal distribution, Superiority trial, Power calculationpower_two_sample_normal
Fixed sample designs: Normal distribution, Non-inferiority trial, Power calculationpower_two_sample_normal_NI
Fixed sample designs: Poisson distribution, Superiority trial, Power calculationpower_two_sample_Poisson
Fixed sample designs: Poisson distribution, Non-inferiority trial, Power calculationpower_two_sample_Poisson_NI
Fixed sample designs: Survival analysis, Superiority trial, Power calculationpower_two_sample_surv_Schoenfeld
Fixed sample designs: Survival analysis, Non-inferiority trial, Power calculationpower_two_sample_surv_Schoenfeld_NI
Group sequential designs / Adaptive sequential designs: Binary distribution, Superiority trial, Sample size calculation, Alpha-spending boundarySample_size_alsp_boundary_binary_diff
Group sequential designs / Adaptive sequential designs: Binary distribution, Non-inferiority trial, Sample size calculation, Alpha-spending boundarySample_size_alsp_boundary_binary_diff_NI
Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Superiority trial, Sample size calculation, Alpha-spending boundarySample_size_alsp_boundary_neg_binomial
Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Non-inferiority trial, Sample size calculation, Alpha-spending boundarySample_size_alsp_boundary_neg_binomial_NI
Group sequential designs / Adaptive sequential designs: Normal distribution, Superiority trial, Sample size calculation, Alpha-spending boundarySample_size_alsp_boundary_normal
Group sequential designs / Adaptive sequential designs: Normal distribution, Non-inferiority trial, Sample size calculation, Alpha-spending boundarySample_size_alsp_boundary_normal_NI
Group sequential designs / Adaptive sequential designs: Poisson distribution, Superiority trial, Sample size calculation, Alpha-spending boundarySample_size_alsp_boundary_poisson
Group sequential designs / Adaptive sequential designs: Poisson distribution, Non-inferiority trial, Sample size calculation, Alpha-spending boundarySample_size_alsp_boundary_poisson_NI
Group sequential designs / Adaptive sequential designs: Survival analysis, Superiority trial, Sample size calculation, Alpha-spending boundarySample_size_alsp_boundary_survival_Schoenfeld
Group sequential designs / Adaptive sequential designs: Survival analysis, Non-inferiority trial, Sample size calculation, Alpha-spending boundarySample_size_alsp_boundary_survival_Schoenfeld_NI
Fixed sample designs: Binary distribution, Superiority trial, Sample size calculationsample_size_binary_diff
Fixed sample designs: Binary distribution, Non-inferiority trial, Sample size calculationsample_size_binary_diff_NI
Fixed sample designs: Negative binomial distribution, Superiority trial, Sample size calculationsample_size_neg_binomial
Fixed sample designs: Negative binomial distribution, Non-inferiority trial, Sample size calculationsample_size_neg_binomial_NI
Group sequential designs / Adaptive sequential designs: Binary distribution, Superiority trial, Sample size calculation, O'Brien-Fleming boundarySample_size_OF_boundary_binary_diff
Group sequential designs / Adaptive sequential designs: Binary distribution, Non-inferiority trial, Sample size calculation, O'Brien-Fleming boundarySample_size_OF_boundary_binary_diff_NI
Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Superiority trial, Sample size calculation, O'Brien-Fleming boundarySample_size_OF_boundary_neg_binomial
Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Non-inferiority trial, Sample size calculation, O'Brien-Fleming boundarySample_size_OF_boundary_neg_binomial_NI
Group sequential designs / Adaptive sequential designs: Normal distribution, Superiority trial, Sample size calculation, O'Brien-Fleming boundarySample_size_OF_boundary_normal
Group sequential designs / Adaptive sequential designs: Normal distribution, Non-inferiority trial, Sample size calculation, O'Brien-Fleming boundarySample_size_OF_boundary_normal_NI
Group sequential designs / Adaptive sequential designs: Poisson distribution, Superiority trial, Sample size calculation, O'Brien-Fleming boundarySample_size_OF_boundary_poisson
Group sequential designs / Adaptive sequential designs: Poisson distribution, Non-inferiority trial, Sample size calculation, O'Brien-Fleming boundarySample_size_OF_boundary_poisson_NI
Group sequential designs / Adaptive sequential designs: Survival analysis, Superiority trial, Sample size calculation, O'Brien-Fleming boundarySample_size_OF_boundary_survival_Schoenfeld
Group sequential designs / Adaptive sequential designs: Survival analysis, Non-inferiority trial, Sample size calculation, O'Brien-Fleming boundarySample_size_OF_boundary_survival_Schoenfeld_NI
Group sequential designs / Adaptive sequential designs: Binary distribution, Superiority trial, Sample size calculation, Pocock boundarySample_size_pocock_boundary_binary_diff
Group sequential designs / Adaptive sequential designs: Binary distribution, Non-inferiority trial, Sample size calculation, Pocock boundarySample_size_pocock_boundary_binary_diff_NI
Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Superiority trial, Sample size calculation, Pocock boundarySample_size_pocock_boundary_neg_binomial
Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Non-inferiority trial, Sample size calculation, Pocock boundarySample_size_pocock_boundary_neg_binomial_NI
Group sequential designs / Adaptive sequential designs: Normal distribution, Superiority trial, Sample size calculation, Pocock boundarySample_size_pocock_boundary_normal
Group sequential designs / Adaptive sequential designs: Normal distribution, Non-inferiority trial, Sample size calculation, Pocock boundarySample_size_pocock_boundary_normal_NI
Group sequential designs / Adaptive sequential designs: Poisson distribution, Superiority trial, Sample size calculation, Pocock boundarySample_size_pocock_boundary_poisson
Group sequential designs / Adaptive sequential designs: Poisson distribution, Non-inferiority trial, Sample size calculation, Pocock boundarySample_size_pocock_boundary_poisson_NI
Group sequential designs / Adaptive sequential designs: Survival analysis, Superiority trial, Sample size calculation, Pocock boundarySample_size_pocock_boundary_survival_Schoenfeld
Group sequential designs / Adaptive sequential designs: Survival analysis, Non-inferiority trial, Sample size calculation, Pocock boundarySample_size_pocock_boundary_survival_Schoenfeld_NI
Fixed sample designs: Normal distribution, Superiority trial, Sample size calculationsample_size_two_sample_normal
Fixed sample designs: Normal distribution, Non-inferiority trial, Sample size calculationsample_size_two_sample_normal_NI
Fixed sample designs: Poisson distribution, Superiority trial, Sample size calculationsample_size_two_sample_Poisson
Fixed sample designs: Poisson distribution, Non-inferiority trial, Sample size calculationsample_size_two_sample_Poisson_NI
Fixed sample designs: Survival analysis, Superiority trial, Sample size calculationsample_size_two_sample_surv_Schoenfeld
Fixed sample designs: Survival analysis, Non-inferiority trial, Sample size calculationsample_size_two_sample_surv_Schoenfeld_NI
Two-stage design: Simon's designsimon_ph2_sz
Phase 2/3 seamless combination Group sequential design: Simulations, Binary distribution, Optimizing adaptive sequential designTwo_stage_asd_simu_OC_binary
Phase 2/3 seamless combination Group sequential design: Simulations, Negative binomial distribution, Optimizing adaptive sequential designTwo_stage_asd_simu_OC_neg_binomial
Phase 2/3 seamless combination Group sequential design: Simulations, Normal distribution, Optimizing adaptive sequential designTwo_stage_asd_simu_OC_normal
Phase 2/3 seamless combination Group sequential design: Simulations, Poisson distribution, Optimizing adaptive sequential designTwo_stage_asd_simu_OC_poisson
Phase 2/3 seamless combination Group sequential design: Simulations, Survival analysis, Optimizing adaptive sequential designTwo_stage_asd_simu_OC_survival
Phase 2/3 seamless combination Group sequential design: Final analysis, Without sample size change, last_vt == 1two_stage_ci_0
Phase 2/3 seamless combination Group sequential design: Final analysis, Without sample size change, last_vt > 1two_stage_ci_1
Phase 2/3 seamless combination Group sequential design: Final analysis, With one sample size changetwo_stage_est_back
Phase 2/3 seamless combination Group sequential design: Binary distribution, Power calculation, Alpha-spending boundarytwo_stage_power_alsp_boundary_binary_diff
Phase 2/3 seamless combination Group sequential design: Negative binomial distribution, Power calculation, Alpha-spending boundarytwo_stage_power_alsp_boundary_neg_binomial
Phase 2/3 seamless combination Group sequential design: Normal distribution, Power calculation, Alpha-spending boundarytwo_stage_power_alsp_boundary_normal
Phase 2/3 seamless combination Group sequential design: Poisson distribution, Power calculation, Alpha-spending boundarytwo_stage_power_alsp_boundary_poisson
Phase 2/3 seamless combination Group sequential design: Survival analysis, Power calculation, Alpha-spending boundarytwo_stage_power_alsp_boundary_survival_Schoenfeld
Phase 2/3 seamless combination Group sequential design: Binary distribution, Power calculation, O'Brien-Fleming boundarytwo_stage_power_OF_boundary_binary_diff
Phase 2/3 seamless combination Group sequential design: Negative binomial distribution, Power calculation, O'Brien-Fleming boundarytwo_stage_power_OF_boundary_neg_binomial
Phase 2/3 seamless combination Group sequential design: Normal distribution, Power calculation, O'Brien-Fleming boundarytwo_stage_power_OF_boundary_normal
Phase 2/3 seamless combination Group sequential design: Poisson distribution, Power calculation, O'Brien-Fleming boundarytwo_stage_power_OF_boundary_poisson
Phase 2/3 seamless combination Group sequential design: Survival analysis, Power calculation, O'Brien-Fleming boundarytwo_stage_power_OF_boundary_survival_Schoenfeld
Phase 2/3 seamless combination Group sequential design: Binary distribution, Sample size calculation, Alpha-spending boundarytwo_stage_Sample_size_alsp_boundary_binary_diff
Phase 2/3 seamless combination Group sequential design: Negative binomial distribution, Sample size calculation, Alpha-spending boundarytwo_stage_Sample_size_alsp_boundary_neg_binomial
Phase 2/3 seamless combination Group sequential design: Normal distribution, Sample size calculation, Alpha-spending boundarytwo_stage_Sample_size_alsp_boundary_normal
Phase 2/3 seamless combination Group sequential design: Poisson distribution, Sample size calculation, Alpha-spending boundarytwo_stage_Sample_size_alsp_boundary_poisson
Phase 2/3 seamless combination Group sequential design: Survival analysis, Sample size calculation, Alpha-spending boundarytwo_stage_Sample_size_alsp_boundary_survival_Schoenfeld
Phase 2/3 seamless combination Group sequential design: Binary distribution, Sample size calculation, O'Brien-Fleming boundarytwo_stage_Sample_size_OF_boundary_binary_diff
Phase 2/3 seamless combination Group sequential design: Negative binomial distribution, Sample size calculation, O'Brien-Fleming boundarytwo_stage_Sample_size_OF_boundary_neg_binomial
Phase 2/3 seamless combination Group sequential design: Normal distribution, Sample size calculation, O'Brien-Fleming boundarytwo_stage_Sample_size_OF_boundary_normal
Phase 2/3 seamless combination Group sequential design: Poisson distribution, Sample size calculation, O'Brien-Fleming boundarytwo_stage_Sample_size_OF_boundary_poisson
Phase 2/3 seamless combination Group sequential design: Survival analysis, Sample size calculation, O'Brien-Fleming boundarytwo_stage_Sample_size_OF_boundary_survival_Schoenfeld
Phase 2/3 seamless combination Group sequential design: Simulations, Binary distribution, Operating characteristicstwo_stg_adapt_power_simu_binary
Phase 2/3 seamless combination Group sequential design: Simulations, Negative binomial distribution, Operating characteristicstwo_stg_adapt_power_simu_neg_binomial
Phase 2/3 seamless combination Group sequential design: Simulations, Normal distribution, Operating characteristicstwo_stg_adapt_power_simu_normal
Phase 2/3 seamless combination Group sequential design: Simulations, Poisson distribution, Operating characteristicstwo_stg_adapt_power_simu_poisson
Phase 2/3 seamless combination Group sequential design: Simulations, Survival analysis, Operating characteristicstwo_stg_adapt_power_simu_survival
Phase 2/3 seamless combination Group sequential design: Simulations, Binary distribution, Type I error and powertwo_stg_power_simu_binary
Phase 2/3 seamless combination Group sequential design: Simulations, Negative binomial distribution, Type I error and powertwo_stg_power_simu_neg_binomial
Phase 2/3 seamless combination Group sequential design: Simulations, Normal distribution, Type I error and powertwo_stg_power_simu_normal
Phase 2/3 seamless combination Group sequential design: Simulations, Poisson distribution, Type I error and powertwo_stg_power_simu_poisson
Phase 2/3 seamless combination Group sequential design: Simulations, Survival analysis, Type I error and powertwo_stg_power_simu_survival