{ "_id": "6aba8e7999f7aa8c6aa4156b", "Package": "DACT", "Version": "1.0.0", "Title": "Design and Analysis for Clinical Trials", "Author": "Ping Gao [aut, cre]", "Maintainer": "Ping Gao ", "Authors@R": "person(given = \"Ping\",\nfamily = \"Gao\",\nrole = c(\"aut\", \"cre\"),\nemail = \"support@innovatiostat.com\")", "Description": "The applications and evaluation of the operating\ncharacteristics of many statistical methodologies require the\nuse of sophisticated software or extensive simulations. 'DACT'\nis designed to serve a wide range of innovative statistical\ndesigns and analyses. The primary objective of the 'DACT'\nsoftware is to promote the understanding and application of\ncutting-edge statistical solutions in clinical trials. For this\nreason, the software is free for non-commercial scientific\nresearch, including but not limited to academic researchers and\nresearch/teaching institutions. Computing codes are available\nupon request. For more details see P. Gao (2024)\n. Gao, P., Zhang, W. (2024)\n. P. Gao & Y. Li (2024)\n. P. Gao, Y. Li (2024)\n. Gao, P., L. Liu, and C.\nMehta. 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"Multiple comparisons Group sequential design: Interim analysis, Non-survival analysis, Input theta", "topics": [ "masd_new_samsz_theta" ] }, { "page": "masd_new_samsz_theta_survival", "title": "Multiple comparisons Group sequential design: Interim analysis, Survival analysis, Input theta", "topics": [ "masd_new_samsz_theta_survival" ] }, { "page": "masd_power_simu_adapt_binary", "title": "Multiple comparisons Group sequential design: Simulations, Binary distribution, Operating characteristics", "topics": [ "masd_power_simu_adapt_binary" ] }, { "page": "masd_power_simu_adapt_neg_binomial", "title": "Multiple comparisons Group sequential design: Simulations, Negative binomial distribution, Operating characteristics", "topics": [ "masd_power_simu_adapt_neg_binomial" ] }, { "page": "masd_power_simu_adapt_normal", "title": "Multiple comparisons Group sequential design: Simulations, Normal distribution, Operating characteristics", "topics": [ "masd_power_simu_adapt_normal" ] }, { "page": "masd_power_simu_adapt_poisson", "title": "Multiple comparisons Group sequential design: Simulations, Poisson distribution, Operating characteristics", "topics": [ "masd_power_simu_adapt_poisson" ] }, { "page": "masd_power_simu_adapt_survival", "title": "Multiple comparisons Group sequential design: Simulations, Survival analysis, Operating characteristics", "topics": [ "masd_power_simu_adapt_survival" ] }, { "page": "masd_simu_OC_binary", "title": "Multiple comparisons Group sequential design: Simulations, Binary distribution, Optimizing adaptive sequential design", "topics": [ "masd_simu_OC_binary" ] }, { "page": "masd_simu_OC_neg_binomial", "title": "Multiple comparisons Group sequential design: Simulations, Negative binomial distribution, Optimizing adaptive sequential design", "topics": [ "masd_simu_OC_neg_binomial" ] }, { "page": "masd_simu_OC_normal", "title": "Multiple comparisons Group sequential design: Simulations, Normal distribution, Optimizing adaptive sequential design", "topics": [ "masd_simu_OC_normal" ] }, { "page": "masd_simu_OC_poisson", "title": "Multiple comparisons Group sequential design: Simulations, Poisson distribution, Optimizing adaptive sequential design", "topics": [ "masd_simu_OC_poisson" ] }, { "page": "masd_simu_OC_survival", "title": "Multiple comparisons Group sequential design: Simulations, Survival analysis, Optimizing adaptive sequential design", "topics": [ "masd_simu_OC_survival" ] }, { "page": "midpnt_sz", "title": "Two-stage design: the midpoint design", "topics": [ "midpnt_sz" ] }, { "page": "MSD_power_alsp_boundary_binary_diff", "title": "Multiple comparisons Group sequential design: Binary distribution, Power calculation, Alpha-spending boundary", "topics": [ "MSD_power_alsp_boundary_binary_diff" ] }, { "page": "MSD_power_alsp_boundary_neg_binomial", "title": "Multiple comparisons Group sequential design: Negative binomial distribution, Power calculation, Alpha-spending boundary", "topics": [ "MSD_power_alsp_boundary_neg_binomial" ] }, { "page": "MSD_power_alsp_boundary_normal", "title": "Multiple comparisons Group sequential design: Normal distribution, Power calculation, Alpha-spending boundary", "topics": [ "MSD_power_alsp_boundary_normal" ] }, { "page": "MSD_power_alsp_boundary_poisson", "title": "Multiple comparisons Group sequential design: Poisson distribution, Power calculation, Alpha-spending boundary", "topics": [ "MSD_power_alsp_boundary_poisson" ] }, { "page": "MSD_power_alsp_boundary_survival_Schoenfeld", "title": "Multiple comparisons Group sequential design: Survival analysis, Power calculation, Alpha-spending boundary", "topics": [ "MSD_power_alsp_boundary_survival_Schoenfeld" ] }, { "page": "MSD_power_OF_boundary_binary_diff", "title": "Multiple comparisons Group sequential design: Binary distribution, Power calculation, O'Brien-Fleming boundary", "topics": [ "MSD_power_OF_boundary_binary_diff" ] }, { "page": "MSD_power_OF_boundary_neg_binomial", "title": "Multiple comparisons Group sequential design: Negative binomial distribution, Power calculation, O'Brien-Fleming boundary", "topics": [ "MSD_power_OF_boundary_neg_binomial" ] }, { "page": "MSD_power_OF_boundary_normal", "title": "Multiple comparisons Group sequential design: Normal distribution, Power calculation, O'Brien-Fleming boundary", "topics": [ "MSD_power_OF_boundary_normal" ] }, { "page": "MSD_power_OF_boundary_poisson", "title": "Multiple comparisons Group sequential design: Poisson distribution, Power calculation, O'Brien-Fleming boundary", "topics": [ "MSD_power_OF_boundary_poisson" ] }, { "page": "MSD_power_OF_boundary_survival_Schoenfeld", "title": "Multiple comparisons Group sequential design: Survival analysis, Power calculation, O'Brien-Fleming boundary", "topics": [ "MSD_power_OF_boundary_survival_Schoenfeld" ] }, { "page": "msd_power_simu_binary", "title": "Multiple comparisons Group sequential design: Simulations, Binary distribution, Type I error and power", "topics": [ "msd_power_simu_binary" ] }, { "page": "msd_power_simu_neg_binomial", "title": "Multiple comparisons Group sequential design: Simulations, Negative binomial distribution, Type I error and power", "topics": [ "msd_power_simu_neg_binomial" ] }, { "page": "msd_power_simu_normal", "title": "Multiple comparisons Group sequential design: Simulations, Normal distribution, Type I error and power", "topics": [ "msd_power_simu_normal" ] }, { "page": "msd_power_simu_poisson", "title": "Multiple comparisons Group sequential design: Simulations, Poisson distribution, Type I error and power", "topics": [ "msd_power_simu_poisson" ] }, { "page": "msd_power_simu_survival", "title": "Multiple comparisons Group sequential design: Simulations, Survival analysis, Type I error and power", "topics": [ "msd_power_simu_survival" ] }, { "page": "MSD_Sample_size_alsp_boundary_binary_diff", "title": "Multiple comparisons Group sequential design: Binary distribution, Sample size calculation, Alpha-spending boundary", "topics": [ "MSD_Sample_size_alsp_boundary_binary_diff" ] }, { "page": "MSD_Sample_size_alsp_boundary_neg_binomial", "title": "Multiple comparisons Group sequential design: Negative binomial distribution, Sample size calculation, Alpha-spending boundary", "topics": [ "MSD_Sample_size_alsp_boundary_neg_binomial" ] }, { "page": "MSD_Sample_size_alsp_boundary_normal", "title": "Multiple comparisons Group sequential design: Normal distribution, Sample size calculation, Alpha-spending boundary", "topics": [ "MSD_Sample_size_alsp_boundary_normal" ] }, { "page": "MSD_Sample_size_alsp_boundary_poisson", "title": "Multiple comparisons Group sequential design: Poisson distribution, Sample size calculation, Alpha-spending boundary", "topics": [ "MSD_Sample_size_alsp_boundary_poisson" ] }, { "page": "MSD_Sample_size_alsp_boundary_survival_Schoenfeld", "title": "Multiple comparisons Group sequential design: Survival analysis, Sample size calculation, Alpha-spending boundary", "topics": [ "MSD_Sample_size_alsp_boundary_survival_Schoenfeld" ] }, { "page": "MSD_Sample_size_OF_boundary_binary_diff", "title": "Multiple comparisons Group sequential design: Binary distribution, Sample size calculation, O'Brien-Fleming boundary", "topics": [ "MSD_Sample_size_OF_boundary_binary_diff" ] }, { "page": "MSD_Sample_size_OF_boundary_neg_binomial", "title": "Multiple comparisons Group sequential design: Negative binomial distribution, Sample size calculation, O'Brien-Fleming boundary", "topics": [ "MSD_Sample_size_OF_boundary_neg_binomial" ] }, { "page": "MSD_Sample_size_OF_boundary_normal", "title": "Multiple comparisons Group sequential design: Normal distribution, Sample size calculation, O'Brien-Fleming boundary", "topics": [ "MSD_Sample_size_OF_boundary_normal" ] }, { "page": "MSD_Sample_size_OF_boundary_poisson", "title": "Multiple comparisons Group sequential design: Poisson distribution, Sample size calculation, O'Brien-Fleming boundary", "topics": [ "MSD_Sample_size_OF_boundary_poisson" ] }, { "page": "MSD_Sample_size_OF_boundary_survival_Schoenfeld", "title": "Multiple comparisons Group sequential design: Survival analysis, Sample size calculation, O'Brien-Fleming boundary", "topics": [ "MSD_Sample_size_OF_boundary_survival_Schoenfeld" ] }, { "page": "new_sample_size_hybrid", "title": "Hybrid: New sample size estimation", "topics": [ "new_sample_size_hybrid" ] }, { "page": "one_arm_ad_3_stg_binary", "title": "Simulations: adaptive three stage design", "topics": [ "one_arm_ad_3_stg_binary" ] }, { "page": "one_arm_ad_two_stg_binary", "title": "Simulations: adaptive two stage design", "topics": [ "one_arm_ad_two_stg_binary" ] }, { "page": "one_arm_rej_2_stg_binary", "title": "Simulations: Two stage fixed expanded Simon's design: either hybrid or mid-point design", "topics": [ "one_arm_rej_2_stg_binary" ] }, { "page": "one_arm_rej_3_stg_binary", "title": "Simulations: Expanded Simon's design: the three stage design, no sample size change", "topics": [ "one_arm_rej_3_stg_binary" ] }, { "page": "one_arm_rej_simon_binary", "title": "Simulations: two stage fixed Simon's design", "topics": [ "one_arm_rej_simon_binary" ] }, { "page": "power_alsp_boundary_binary_diff", "title": "Group sequential designs / Adaptive sequential designs: Binary distribution, Superiority trial, Power calculation, Alpha-spending boundary", "topics": [ "power_alsp_boundary_binary_diff" ] }, { "page": "power_alsp_boundary_binary_diff_NI", "title": "Group sequential designs / Adaptive sequential designs: Binary distribution, Non-inferiority trial, Power calculation, Alpha-spending boundary", "topics": [ "power_alsp_boundary_binary_diff_NI" ] }, { "page": "power_alsp_boundary_neg_binomial", "title": "Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Superiority trial, Power calculation, Alpha-spending boundary", "topics": [ "power_alsp_boundary_neg_binomial" ] }, { "page": "power_alsp_boundary_neg_binomial_NI", "title": "Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Non-inferiority trial, Power calculation, Alpha-spending boundary", "topics": [ "power_alsp_boundary_neg_binomial_NI" ] }, { "page": "power_alsp_boundary_normal", "title": "Group sequential designs / Adaptive sequential designs: Normal distribution, Superiority trial, Power calculation, Alpha-spending boundary", "topics": [ "power_alsp_boundary_normal" ] }, { "page": "power_alsp_boundary_normal_NI", "title": "Group sequential designs / Adaptive sequential designs: Normal distribution, Non-inferiority trial, Power calculation, Alpha-spending boundary", "topics": [ "power_alsp_boundary_normal_NI" ] }, { "page": "power_alsp_boundary_poisson", "title": "Group sequential designs / Adaptive sequential designs: Poisson distribution, Superiority trial, Power calculation, Alpha-spending boundary", "topics": [ "power_alsp_boundary_poisson" ] }, { "page": "power_alsp_boundary_poisson_NI", "title": "Group sequential designs / Adaptive sequential designs: Poisson distribution, Non-inferiority trial, Power calculation, Alpha-spending boundary", "topics": [ "power_alsp_boundary_poisson_NI" ] }, { "page": "power_alsp_boundary_survival_Schoenfeld", "title": "Group sequential designs / Adaptive sequential designs: Survival analysis, Superiority trial, Power calculation, Alpha-spending boundary", "topics": [ "power_alsp_boundary_survival_Schoenfeld" ] }, { "page": "power_alsp_boundary_survival_Schoenfeld_NI", "title": "Group sequential designs / Adaptive sequential designs: Survival analysis, Non-inferiority trial, Power calculation, Alpha-spending boundary", "topics": [ "power_alsp_boundary_survival_Schoenfeld_NI" ] }, { "page": "power_binary_diff", "title": "Fixed sample designs: Binary distribution, Superiority trial, Power calculation", "topics": [ "power_binary_diff" ] }, { "page": "power_binary_diff_NI", "title": "Fixed sample designs: Binary distribution, Non-inferiority trial, Power calculation", "topics": [ "power_binary_diff_NI" ] }, { "page": "power_OF_boundary_binary_diff", "title": "Group sequential designs / Adaptive sequential designs: Binary distribution, Superiority trial, Power calculation, O'Brien-Fleming boundary", "topics": [ "power_OF_boundary_binary_diff" ] }, { "page": "power_OF_boundary_binary_diff_NI", "title": "Group sequential designs / Adaptive sequential designs: Binary distribution, Non-inferiority trial, Power calculation, O'Brien-Fleming boundary", "topics": [ "power_OF_boundary_binary_diff_NI" ] }, { "page": "power_OF_boundary_neg_binomial", "title": "Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Superiority trial, Power calculation, O'Brien-Fleming boundary", "topics": [ "power_OF_boundary_neg_binomial" ] }, { "page": "power_OF_boundary_neg_binomial_NI", "title": "Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Non-inferiority trial, Power calculation, O'Brien-Fleming boundary", "topics": [ "power_OF_boundary_neg_binomial_NI" ] }, { "page": "power_OF_boundary_normal", "title": "Group sequential designs / Adaptive sequential designs: Normal distribution, Superiority trial, Power calculation, O'Brien-Fleming boundary", "topics": [ "power_OF_boundary_normal" ] }, { "page": "power_OF_boundary_normal_NI", "title": "Group sequential designs / Adaptive sequential designs: Normal distribution, Non-inferiority trial, Power calculation, O'Brien-Fleming boundary", "topics": [ "power_OF_boundary_normal_NI" ] }, { "page": "power_OF_boundary_poisson", "title": "Group sequential designs / Adaptive sequential designs: Poisson distribution, Superiority trial, Power calculation, O'Brien-Fleming boundary", "topics": [ "power_OF_boundary_poisson" ] }, { "page": "power_OF_boundary_poisson_NI", "title": "Group sequential designs / Adaptive sequential designs: Poisson distribution, Non-inferiority trial, Power calculation, O'Brien-Fleming boundary", "topics": [ "power_OF_boundary_poisson_NI" ] }, { "page": "power_OF_boundary_survival_Schoenfeld", "title": "Group sequential designs / Adaptive sequential designs: Survival analysis, Superiority trial, Power calculation, O'Brien-Fleming boundary", "topics": [ "power_OF_boundary_survival_Schoenfeld" ] }, { "page": "power_OF_boundary_survival_Schoenfeld_NI", "title": "Group sequential designs / Adaptive sequential designs: Survival analysis, Non-inferiority trial, Power calculation, O'Brien-Fleming boundary", "topics": [ "power_OF_boundary_survival_Schoenfeld_NI" ] }, { "page": "power_pocock_boundary_binary_diff", "title": "Group sequential designs / Adaptive sequential designs: Binary distribution, Superiority trial, Power calculation, Pocock boundary", "topics": [ "power_pocock_boundary_binary_diff" ] }, { "page": "power_pocock_boundary_binary_diff_NI", "title": "Group sequential designs / Adaptive sequential designs: Binary distribution, Non-inferiority trial, Power calculation, Pocock boundary", "topics": [ "power_pocock_boundary_binary_diff_NI" ] }, { "page": "power_pocock_boundary_neg_binomial", "title": "Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Superiority trial, Power calculation, Pocock boundary", "topics": [ "power_pocock_boundary_neg_binomial" ] }, { "page": "power_pocock_boundary_neg_binomial_NI", "title": "Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Non-inferiority trial, Power calculation, Pocock boundary", "topics": [ "power_pocock_boundary_neg_binomial_NI" ] }, { "page": "power_pocock_boundary_normal", "title": "Group sequential designs / Adaptive sequential designs: Normal distribution, Superiority trial, Power calculation, Pocock boundary", "topics": [ "power_pocock_boundary_normal" ] }, { "page": "power_pocock_boundary_normal_NI", "title": "Group sequential designs / Adaptive sequential designs: Normal distribution, Non-inferiority trial, Power calculation, Pocock boundary", "topics": [ "power_pocock_boundary_normal_NI" ] }, { "page": "power_pocock_boundary_poisson", "title": "Group sequential designs / Adaptive sequential designs: Poisson distribution, Superiority trial, Power calculation, Pocock boundary", "topics": [ "power_pocock_boundary_poisson" ] }, { "page": "power_pocock_boundary_poisson_NI", "title": "Group sequential designs / Adaptive sequential designs: Poisson distribution, Non-inferiority trial, Power calculation, Pocock boundary", "topics": [ "power_pocock_boundary_poisson_NI" ] }, { "page": "power_pocock_boundary_survival_Schoenfeld", "title": "Group sequential designs / Adaptive sequential designs: Survival analysis, Superiority trial, Power calculation, Pocock boundary", "topics": [ "power_pocock_boundary_survival_Schoenfeld" ] }, { "page": "power_pocock_boundary_survival_Schoenfeld_NI", "title": "Group sequential designs / Adaptive sequential designs: Survival analysis, Non-inferiority trial, Power calculation, Pocock boundary", "topics": [ "power_pocock_boundary_survival_Schoenfeld_NI" ] }, { "page": "power_two_sample_neg_binomial", "title": "Fixed sample designs: Negative binomial distribution, Superiority trial, Power calculation", "topics": [ "power_two_sample_neg_binomial" ] }, { "page": "power_two_sample_neg_binomial_NI", "title": "Fixed sample designs: Negative binomial distribution, Non-inferiority trial, Power calculation", "topics": [ "power_two_sample_neg_binomial_NI" ] }, { "page": "power_two_sample_normal", "title": "Fixed sample designs: Normal distribution, Superiority trial, Power calculation", "topics": [ "power_two_sample_normal" ] }, { "page": "power_two_sample_normal_NI", "title": "Fixed sample designs: Normal distribution, Non-inferiority trial, Power calculation", "topics": [ "power_two_sample_normal_NI" ] }, { "page": "power_two_sample_Poisson", "title": "Fixed sample designs: Poisson distribution, Superiority trial, Power calculation", "topics": [ "power_two_sample_Poisson" ] }, { "page": "power_two_sample_Poisson_NI", "title": "Fixed sample designs: Poisson distribution, Non-inferiority trial, Power calculation", "topics": [ "power_two_sample_Poisson_NI" ] }, { "page": "power_two_sample_surv_Schoenfeld", "title": "Fixed sample designs: Survival analysis, Superiority trial, Power calculation", "topics": [ "power_two_sample_surv_Schoenfeld" ] }, { "page": "power_two_sample_surv_Schoenfeld_NI", "title": "Fixed sample designs: Survival analysis, Non-inferiority trial, Power calculation", "topics": [ "power_two_sample_surv_Schoenfeld_NI" ] }, { "page": "Sample_size_alsp_boundary_binary_diff", "title": "Group sequential designs / Adaptive sequential designs: Binary distribution, Superiority trial, Sample size calculation, Alpha-spending boundary", "topics": [ "Sample_size_alsp_boundary_binary_diff" ] }, { "page": "Sample_size_alsp_boundary_binary_diff_NI", "title": "Group sequential designs / Adaptive sequential designs: Binary distribution, Non-inferiority trial, Sample size calculation, Alpha-spending boundary", "topics": [ "Sample_size_alsp_boundary_binary_diff_NI" ] }, { "page": "Sample_size_alsp_boundary_neg_binomial", "title": "Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Superiority trial, Sample size calculation, Alpha-spending boundary", "topics": [ "Sample_size_alsp_boundary_neg_binomial" ] }, { "page": "Sample_size_alsp_boundary_neg_binomial_NI", "title": "Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Non-inferiority trial, Sample size calculation, Alpha-spending boundary", "topics": [ "Sample_size_alsp_boundary_neg_binomial_NI" ] }, { "page": "Sample_size_alsp_boundary_normal", "title": "Group sequential designs / Adaptive sequential designs: Normal distribution, Superiority trial, Sample size calculation, Alpha-spending boundary", "topics": [ "Sample_size_alsp_boundary_normal" ] }, { "page": "Sample_size_alsp_boundary_normal_NI", "title": "Group sequential designs / Adaptive sequential designs: Normal distribution, Non-inferiority trial, Sample size calculation, Alpha-spending boundary", "topics": [ "Sample_size_alsp_boundary_normal_NI" ] }, { "page": "Sample_size_alsp_boundary_poisson", "title": "Group sequential designs / Adaptive sequential designs: Poisson distribution, Superiority trial, Sample size calculation, Alpha-spending boundary", "topics": [ "Sample_size_alsp_boundary_poisson" ] }, { "page": "Sample_size_alsp_boundary_poisson_NI", "title": "Group sequential designs / Adaptive sequential designs: Poisson distribution, Non-inferiority trial, Sample size calculation, Alpha-spending boundary", "topics": [ "Sample_size_alsp_boundary_poisson_NI" ] }, { "page": "Sample_size_alsp_boundary_survival_Schoenfeld", "title": "Group sequential designs / Adaptive sequential designs: Survival analysis, Superiority trial, Sample size calculation, Alpha-spending boundary", "topics": [ "Sample_size_alsp_boundary_survival_Schoenfeld" ] }, { "page": "Sample_size_alsp_boundary_survival_Schoenfeld_NI", "title": "Group sequential designs / Adaptive sequential designs: Survival analysis, Non-inferiority trial, Sample size calculation, Alpha-spending boundary", "topics": [ "Sample_size_alsp_boundary_survival_Schoenfeld_NI" ] }, { "page": "sample_size_binary_diff", "title": "Fixed sample designs: Binary distribution, Superiority trial, Sample size calculation", "topics": [ "sample_size_binary_diff" ] }, { "page": "sample_size_binary_diff_NI", "title": "Fixed sample designs: Binary distribution, Non-inferiority trial, Sample size calculation", "topics": [ "sample_size_binary_diff_NI" ] }, { "page": "sample_size_neg_binomial", "title": "Fixed sample designs: Negative binomial distribution, Superiority trial, Sample size calculation", "topics": [ "sample_size_neg_binomial" ] }, { "page": "sample_size_neg_binomial_NI", "title": "Fixed sample designs: Negative binomial distribution, Non-inferiority trial, Sample size calculation", "topics": [ "sample_size_neg_binomial_NI" ] }, { "page": "Sample_size_OF_boundary_binary_diff", "title": "Group sequential designs / Adaptive sequential designs: Binary distribution, Superiority trial, Sample size calculation, O'Brien-Fleming boundary", "topics": [ "Sample_size_OF_boundary_binary_diff" ] }, { "page": "Sample_size_OF_boundary_binary_diff_NI", "title": "Group sequential designs / Adaptive sequential designs: Binary distribution, Non-inferiority trial, Sample size calculation, O'Brien-Fleming boundary", "topics": [ "Sample_size_OF_boundary_binary_diff_NI" ] }, { "page": "Sample_size_OF_boundary_neg_binomial", "title": "Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Superiority trial, Sample size calculation, O'Brien-Fleming boundary", "topics": [ "Sample_size_OF_boundary_neg_binomial" ] }, { "page": "Sample_size_OF_boundary_neg_binomial_NI", "title": "Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Non-inferiority trial, Sample size calculation, O'Brien-Fleming boundary", "topics": [ "Sample_size_OF_boundary_neg_binomial_NI" ] }, { "page": "Sample_size_OF_boundary_normal", "title": "Group sequential designs / Adaptive sequential designs: Normal distribution, Superiority trial, Sample size calculation, O'Brien-Fleming boundary", "topics": [ "Sample_size_OF_boundary_normal" ] }, { "page": "Sample_size_OF_boundary_normal_NI", "title": "Group sequential designs / Adaptive sequential designs: Normal distribution, Non-inferiority trial, Sample size calculation, O'Brien-Fleming boundary", "topics": [ "Sample_size_OF_boundary_normal_NI" ] }, { "page": "Sample_size_OF_boundary_poisson", "title": "Group sequential designs / Adaptive sequential designs: Poisson distribution, Superiority trial, Sample size calculation, O'Brien-Fleming boundary", "topics": [ "Sample_size_OF_boundary_poisson" ] }, { "page": "Sample_size_OF_boundary_poisson_NI", "title": "Group sequential designs / Adaptive sequential designs: Poisson distribution, Non-inferiority trial, Sample size calculation, O'Brien-Fleming boundary", "topics": [ "Sample_size_OF_boundary_poisson_NI" ] }, { "page": "Sample_size_OF_boundary_survival_Schoenfeld", "title": "Group sequential designs / Adaptive sequential designs: Survival analysis, Superiority trial, Sample size calculation, O'Brien-Fleming boundary", "topics": [ "Sample_size_OF_boundary_survival_Schoenfeld" ] }, { "page": "Sample_size_OF_boundary_survival_Schoenfeld_NI", "title": "Group sequential designs / Adaptive sequential designs: Survival analysis, Non-inferiority trial, Sample size calculation, O'Brien-Fleming boundary", "topics": [ "Sample_size_OF_boundary_survival_Schoenfeld_NI" ] }, { "page": "Sample_size_pocock_boundary_binary_diff", "title": "Group sequential designs / Adaptive sequential designs: Binary distribution, Superiority trial, Sample size calculation, Pocock boundary", "topics": [ "Sample_size_pocock_boundary_binary_diff" ] }, { "page": "Sample_size_pocock_boundary_binary_diff_NI", "title": "Group sequential designs / Adaptive sequential designs: Binary distribution, Non-inferiority trial, Sample size calculation, Pocock boundary", "topics": [ "Sample_size_pocock_boundary_binary_diff_NI" ] }, { "page": "Sample_size_pocock_boundary_neg_binomial", "title": "Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Superiority trial, Sample size calculation, Pocock boundary", "topics": [ "Sample_size_pocock_boundary_neg_binomial" ] }, { "page": "Sample_size_pocock_boundary_neg_binomial_NI", "title": "Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Non-inferiority trial, Sample size calculation, Pocock boundary", "topics": [ "Sample_size_pocock_boundary_neg_binomial_NI" ] }, { "page": "Sample_size_pocock_boundary_normal", "title": "Group sequential designs / Adaptive sequential designs: Normal distribution, Superiority trial, Sample size calculation, Pocock boundary", "topics": [ "Sample_size_pocock_boundary_normal" ] }, { "page": "Sample_size_pocock_boundary_normal_NI", "title": "Group sequential designs / Adaptive sequential designs: Normal distribution, Non-inferiority trial, Sample size calculation, Pocock boundary", "topics": [ "Sample_size_pocock_boundary_normal_NI" ] }, { "page": "Sample_size_pocock_boundary_poisson", "title": "Group sequential designs / Adaptive sequential designs: Poisson distribution, Superiority trial, Sample size calculation, Pocock boundary", "topics": [ "Sample_size_pocock_boundary_poisson" ] }, { "page": "Sample_size_pocock_boundary_poisson_NI", "title": "Group sequential designs / Adaptive sequential designs: Poisson distribution, Non-inferiority trial, Sample size calculation, Pocock boundary", "topics": [ "Sample_size_pocock_boundary_poisson_NI" ] }, { "page": "Sample_size_pocock_boundary_survival_Schoenfeld", "title": "Group sequential designs / Adaptive sequential designs: Survival analysis, Superiority trial, Sample size calculation, Pocock boundary", "topics": [ "Sample_size_pocock_boundary_survival_Schoenfeld" ] }, { "page": "Sample_size_pocock_boundary_survival_Schoenfeld_NI", "title": "Group sequential designs / Adaptive sequential designs: Survival analysis, Non-inferiority trial, Sample size calculation, Pocock boundary", "topics": [ "Sample_size_pocock_boundary_survival_Schoenfeld_NI" ] }, { "page": "sample_size_two_sample_normal", "title": "Fixed sample designs: Normal distribution, Superiority trial, Sample size calculation", "topics": [ "sample_size_two_sample_normal" ] }, { "page": "sample_size_two_sample_normal_NI", "title": "Fixed sample designs: Normal distribution, Non-inferiority trial, Sample size calculation", "topics": [ "sample_size_two_sample_normal_NI" ] }, { "page": "sample_size_two_sample_Poisson", "title": "Fixed 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