Package: BElikelihood 1.1
Liping Du
BElikelihood: Likelihood Method for Evaluating Bioequivalence
A likelihood method is implemented to present evidence for evaluating bioequivalence (BE). The functions use bioequivalence data [area under the blood concentration-time curve (AUC) and peak concentration (Cmax)] from various crossover designs commonly used in BE studies including a fully replicated, a partially replicated design, and a conventional 2x2 crossover design. They will calculate the profile likelihoods for the mean difference, total standard deviation ratio, and within subject standard deviation ratio for a test and a reference drug. A plot of a standardized profile likelihood can be generated along with the maximum likelihood estimate and likelihood intervals, which present evidence for bioequivalence. See Liping Du and Leena Choi (2015) <doi:10.1002/pst.1661>.
Authors:
BElikelihood_1.1.tar.gz
BElikelihood_1.1.tar.gz(r-4.5-noble)BElikelihood_1.1.tar.gz(r-4.4-noble)
BElikelihood_1.1.tgz(r-4.4-emscripten)BElikelihood_1.1.tgz(r-4.3-emscripten)
BElikelihood.pdf |BElikelihood.html✨
BElikelihood/json (API)
| # Install 'BElikelihood' in R: |
| install.packages('BElikelihood', repos = c('https://cran.r-universe.dev', 'https://cloud.r-project.org')) |
- dat - Data example for bioequivalence (BE) study
This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.
Last updated 9 months agofrom:83134c519e. Checks:OK: 1 WARNING: 1. Indexed: yes.
| Target | Result | Date |
|---|---|---|
| Doc / Vignettes | OK | Nov 01 2024 |
| R-4.5-linux | WARNING | Nov 01 2024 |
Exports:averageBEproLikelihoodtotalVarianceBEwithinVarianceBE
Dependencies:clicolorspacefansifarverggplot2gluegtableisobandlabelinglatticelifecyclemagrittrMASSMatrixmgcvmunsellmvtnormnlmepillarpkgconfigR6RColorBrewerrlangscalestibbleutf8vctrsviridisLitewithr
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| Likelihood method for analyzing bioequivalence (BE) trial data | BElikelihood-package BElikelihood |
| Data example for bioequivalence (BE) study | dat |
| Plot method for proLikelihood object | plot.proLikelihood |
| Print method for proLikelihood object | print.proLikelihood |
| Calculate profile likelihood for bioequivalence data | averageBE proLikelihood totalVarianceBE withinVarianceBE |