Package: BElikelihood 1.1

Liping Du

BElikelihood: Likelihood Method for Evaluating Bioequivalence

A likelihood method is implemented to present evidence for evaluating bioequivalence (BE). The functions use bioequivalence data [area under the blood concentration-time curve (AUC) and peak concentration (Cmax)] from various crossover designs commonly used in BE studies including a fully replicated, a partially replicated design, and a conventional 2x2 crossover design. They will calculate the profile likelihoods for the mean difference, total standard deviation ratio, and within subject standard deviation ratio for a test and a reference drug. A plot of a standardized profile likelihood can be generated along with the maximum likelihood estimate and likelihood intervals, which present evidence for bioequivalence. See Liping Du and Leena Choi (2015) <doi:10.1002/pst.1661>.

Authors:Liping Du [aut, cre], Leena Choi [aut], Cole Beck [aut]

BElikelihood_1.1.tar.gz
BElikelihood_1.1.tar.gz(r-4.5-noble)BElikelihood_1.1.tar.gz(r-4.4-noble)
BElikelihood_1.1.tgz(r-4.4-emscripten)BElikelihood_1.1.tgz(r-4.3-emscripten)
BElikelihood.pdf |BElikelihood.html
BElikelihood/json (API)

# Install 'BElikelihood' in R:
install.packages('BElikelihood', repos = c('https://cran.r-universe.dev', 'https://cloud.r-project.org'))

Peer review:

Datasets:
  • dat - Data example for bioequivalence (BE) study

This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.

2.00 score 191 downloads 4 exports 29 dependencies

Last updated 10 months agofrom:83134c519e. Checks:OK: 1 WARNING: 1. Indexed: yes.

TargetResultDate
Doc / VignettesOKDec 01 2024
R-4.5-linuxWARNINGDec 01 2024

Exports:averageBEproLikelihoodtotalVarianceBEwithinVarianceBE

Dependencies:clicolorspacefansifarverggplot2gluegtableisobandlabelinglatticelifecyclemagrittrMASSMatrixmgcvmunsellmvtnormnlmepillarpkgconfigR6RColorBrewerrlangscalestibbleutf8vctrsviridisLitewithr

BElikelihood

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Last update: 2024-03-06
Started: 2024-03-06