{ "_id": "6ab25bb33d719c1f8408c766", "Package": "BElikelihood", "Type": "Package", "Title": "Likelihood Method for Evaluating Bioequivalence", "Version": "1.1", "Date": "2024-02-29", "Maintainer": "Liping Du ", "Authors@R": "c(person(\"Liping\", \"Du\", role = c(\"aut\", \"cre\"),\nemail = \"liping.du@vumc.org\",\ncomment=c(ORCID = \"0000-0003-4926-2135\")),\nperson(\"Leena\", \"Choi\", role = \"aut\",\nemail = \"naturechoi@gmail.com\",\ncomment = c(ORCID = \"0000-0002-2544-7090\")),\nperson(\"Cole\", \"Beck\", role = \"aut\",\nemail = \"cole.beck@vumc.org\",\ncomment = c(ORCID = \"0000-0002-6849-6255\")))", "Description": "A likelihood method is implemented to present evidence for\nevaluating bioequivalence (BE). The functions use\nbioequivalence data [area under the blood concentration-time\ncurve (AUC) and peak concentration (Cmax)] from various\ncrossover designs commonly used in BE studies including a fully\nreplicated, a partially replicated design, and a conventional\n2x2 crossover design. They will calculate the profile\nlikelihoods for the mean difference, total standard deviation\nratio, and within subject standard deviation ratio for a test\nand a reference drug. A plot of a standardized profile\nlikelihood can be generated along with the maximum likelihood\nestimate and likelihood intervals, which present evidence for\nbioequivalence. See Liping Du and Leena Choi (2015)\n.", "License": "GPL (>= 3)", "RoxygenNote": "7.3.1", "VignetteBuilder": "knitr", "NeedsCompilation": "no", "Packaged": { "Date": "2026-09-22 10:39:46 UTC", "User": "root" }, "Author": "Liping Du [aut, cre] (),\nLeena Choi [aut] (),\nCole Beck [aut] ()", "Repository": "https://cran.r-universe.dev", "Date/Publication": "2024-03-06 02:29:02 UTC", "RemoteUrl": "https://github.com/cran/BElikelihood", "RemoteRef": "HEAD", "RemoteSha": "83134c519ed331d1330befb2fd6e83f75c0e5ec3", "_user": "cran", "_type": "src", "_file": "BElikelihood_1.1.tar.gz", "_fileid": "https://r2.ropensci.org/0872805f4310ad80e3152b29371e315bae274b1e231d4487d8d5edd3729937a0", "_filesize": 659318, "_sha256": "0872805f4310ad80e3152b29371e315bae274b1e231d4487d8d5edd3729937a0", "_expires": "2026-12-31T10:42:57.000Z", "_created": "2026-09-22T10:39:46.000Z", "_published": "2026-09-22T10:42:59.366Z", "_jobs": [ { "job": 106711518769, "time": 151, "config": "linux-devel-x86_64", "r": "4.7.0", 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