Package: visit 2.2

Chenguang Wang

visit: Vaccine Phase I Design with Simultaneous Evaluation of Immunogenicity and Toxicity

Phase I clinical trials are the first step in drug development to test a new drug or drug combination on humans. Typical designs of Phase I trials use toxicity as the primary endpoint and aim to find the maximum tolerable dosage. However, these designs are poorly applicable for the development of cancer therapeutic vaccines because the expected safety concerns for these vaccines are not as much as cytotoxic agents. The primary objectives of a cancer therapeutic vaccine phase I trial thus often include determining whether the vaccine shows biologic activity and the minimum dose necessary to achieve a full immune or even clinical response. This package implements a Bayesian Phase I cancer vaccine trial design that allows simultaneous evaluation of safety and immunogenicity outcomes. See Wang et al. (2019) <doi:10.1002/sim.8021> for further details.

Authors:Zilu Wang [aut, cre] Chenguang Wang [aut, cre] Gary L Rosner [aut] Richard BS Roden [aut] Trustees of Columbia University [cph]

visit_2.2.tar.gz
visit_2.2.tar.gz(r-4.5-noble)visit_2.2.tar.gz(r-4.4-noble)
visit.pdf |visit.html
visit/json (API)

# Install 'visit' in R:
install.packages('visit', repos = c('https://cran.r-universe.dev', 'https://cloud.r-project.org'))

Peer review:

Uses libs:
  • c++– GNU Standard C++ Library v3

This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.

cpp

2.00 score 132 downloads 10 exports 67 dependencies

Last updated 1 years agofrom:e22b97c4d5. Checks:OK: 1 NOTE: 1. Indexed: yes.

TargetResultDate
Doc / VignettesOKNov 25 2024
R-4.5-linux-x86_64NOTENov 25 2024

Exports:summary2vtDecMapvtInterimvtPostvtPriorParvtScenariovtShinyvtSimuvtSingleTrialvtTrack

Dependencies:abindbackportsBHbitbit64blobcachemcallrcheckmatechronclicolorspacecpp11DBIdescdistributionalfansifarverfastmapgenericsggplot2gluegridExtragsubfngtableinlineisobandlabelinglatticelifecycleloomagrittrMASSMatrixmatrixStatsmemoisemgcvmunsellnlmenumDerivpillarpkgbuildpkgconfigplogrposteriorprocessxprotopsQuickJSRR6RColorBrewerRcppRcppEigenRcppParallelrlangRSQLiterstanrstantoolsscalessqldfStanHeaderstensorAtibbleutf8vctrsviridisLitewithr

visit: Vaccine Phase I Design with Simultaneous Evaluation of Immnunogeneicity and Toxicity

Rendered fromvignette.Rmdusingknitr::rmarkdownon Nov 25 2024.

Last update: 2023-08-09
Started: 2019-08-26