Package: phase1PRMD 1.0.2

Lu Zhang

phase1PRMD: Personalized Repeated Measurement Design for Phase I Clinical Trials

Implements Bayesian phase I repeated measurement design that accounts for multidimensional toxicity endpoints and longitudinal efficacy measure from multiple treatment cycles. The package provides flags to fit a variety of model-based phase I design, including 1 stage models with or without individualized dose modification, 3-stage models with or without individualized dose modification, etc. Functions are provided to recommend dosage selection based on the data collected in the available patient cohorts and to simulate trial characteristics given design parameters. Yin, Jun, et al. (2017) <doi:10.1002/sim.7134>.

Authors:Lu Zhang, Jun Yin

phase1PRMD_1.0.2.tar.gz
phase1PRMD_1.0.2.tar.gz(r-4.7-any)phase1PRMD_1.0.2.tar.gz(r-4.6-any)
phase1PRMD_1.0.2.tgz(r-4.6-emscripten)
manual.pdf |manual.html
card.svg |card.png
phase1PRMD/json (API)
NEWS

# Install 'phase1PRMD' in R:
install.packages('phase1PRMD', repos = c('https://cran.r-universe.dev', 'https://cloud.r-project.org'))
Uses libs:
  • jags– Just Another Gibbs Sampler for Bayesian MCMC - binary JAGS is Just Another Gibbs Sampler. It is a program for analysis of Bayesian hierarchical models using Markov Chain Monte Carlo (MCMC) simulation not wholly unlike BUGS. JAGS was written with three aims in mind: * To have an engine for the BUGS language that runs on Unix * To be extensible, allowing users to write their own functions, distributions and samplers. * To be a plaftorm for experimentation with ideas in Bayesian modelling This package contains the 'jags' binary as well as the associated shared library modules loaded by the binary.
  • c++– GNU Standard C++ Library v3
Datasets:
  • eff - Efficacy response generation parameters
  • patlist_sim - A list of patient information
  • prob - Toxicity probability matrix

On CRAN:

Conda:

This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.

jagscpp

1.74 score 11 scripts 135 downloads 7 exports 64 dependencies

Last updated from:3227d3276f. Checks:4 OK. Indexed: no.

TargetResultTimeFilesSyslog
linux-devel-x86_64OK140
source / vignettesOK212
linux-release-x86_64OK148
wasm-releaseOK127

Exports:eff_suggesteff_summarynTTP_summarynTTP.arraypatlist.displayRunPRMDSimPRMD

Dependencies:arrayhelpersbase64encbslibcachemclicodacpp11digestdplyrevaluatefarverfastmapfontawesomefsgenericsggplot2gluegridExtragtablehighrhtmltoolsisobandjquerylibjsonlitekableExtraknitrlabelinglatticelifecyclemagrittrMASSmemoisemimepillarpkgconfigplyrR6rappdirsRColorBrewerRcppreshape2rjagsrlangrmarkdownrstudioapiS7sassscalesstringistringrsvglitesvUnitsystemfontstextshapingtibbletidyselecttinytexutf8vctrsviridisLitewithrxfunxml2yaml