Package: dotgen 0.1.1

Xiaoran Tong

dotgen: Gene-Set Analysis via Decorrelation by Orthogonal Transformation

Decorrelates a set of summary statistics (i.e., Z-scores or P-values per SNP) via Decorrelation by Orthogonal Transformation (DOT) approach and performs gene-set analyses by combining transformed statistic values; operations are performed with algorithms that rely only on the association summary results and the linkage disequilibrium (LD). For more details on DOT and its power, see Olga (2020) <doi:10.1371/journal.pcbi.1007819>.

Authors:Olga Vsevolozhskaya [aut], Dmitri Zaykin [aut], Xiaoran Tong [aut, cre]

dotgen_0.1.1.tar.gz
dotgen_0.1.1.tar.gz(r-4.5-noble)dotgen_0.1.1.tar.gz(r-4.4-noble)
dotgen_0.1.1.tgz(r-4.4-emscripten)dotgen_0.1.1.tgz(r-4.3-emscripten)
dotgen.pdf |dotgen.html✨
dotgen/json (API)

# Install 'dotgen' in R:
install.packages('dotgen', repos = 'https://cloud.r-project.org')

Bug tracker:https://github.com/xiaoran831213/dotgen/issues

On CRAN:

Conda:

1.00 score 498 downloads 9 exports 1 dependencies

Last updated 5 months agofrom:743d9fc137. Checks:3 OK. Indexed: no.

TargetResultLatest binary
Doc / VignettesOKMar 27 2025
R-4.5-linuxOKMar 27 2025
R-4.4-linuxOKMar 27 2025

Exports:cstdotdot_artdot_artadot_chisqdot_fisherdot_rtpdot_tpmzsc

Dependencies:mvtnorm

Citation

To cite package ‘dotgen’ in publications use:

Vsevolozhskaya O, Zaykin D, Tong X (2024). dotgen: Gene-Set Analysis via Decorrelation by Orthogonal Transformation. R package version 0.1.1, https://CRAN.R-project.org/package=dotgen.

Corresponding BibTeX entry: 

  @Manual{,
    title = {dotgen: Gene-Set Analysis via Decorrelation by Orthogonal
      Transformation},
    author = {Olga Vsevolozhskaya and Dmitri Zaykin and Xiaoran Tong},
    year = {2024},
    note = {R package version 0.1.1},
    url = {https://CRAN.R-project.org/package=dotgen},
  }