Package: dotgen 0.1.1
Xiaoran Tong
dotgen: Gene-Set Analysis via Decorrelation by Orthogonal Transformation
Decorrelates a set of summary statistics (i.e., Z-scores or P-values per SNP) via Decorrelation by Orthogonal Transformation (DOT) approach and performs gene-set analyses by combining transformed statistic values; operations are performed with algorithms that rely only on the association summary results and the linkage disequilibrium (LD). For more details on DOT and its power, see Olga (2020) <doi:10.1371/journal.pcbi.1007819>.
Authors:
dotgen_0.1.1.tar.gz
dotgen_0.1.1.tar.gz(r-4.5-noble)dotgen_0.1.1.tar.gz(r-4.4-noble)
dotgen_0.1.1.tgz(r-4.4-emscripten)dotgen_0.1.1.tgz(r-4.3-emscripten)
dotgen.pdf |dotgen.html✨
dotgen/json (API)
| # Install 'dotgen' in R: |
| install.packages('dotgen', repos = c('https://cran.r-universe.dev', 'https://cloud.r-project.org')) |
Bug tracker:https://github.com/xiaoran831213/dotgen/issues
Last updated 3 days agofrom:743d9fc137. Checks:OK: 2. Indexed: no.
| Target | Result | Date |
|---|---|---|
| Doc / Vignettes | OK | Oct 28 2024 |
| R-4.5-linux | OK | Oct 28 2024 |
Exports:cstdotdot_artdot_artadot_chisqdot_fisherdot_rtpdot_tpmzsc
Dependencies:mvtnorm
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| Correlation among association test statistics | cst |
| Decorrelation by Orthogonal Transformation (DOT) | dot |
| Methods for combining decorrelated summary statistics | dot_art dot_arta dot_chisq dot_fisher dot_rtp dot_sst dot_tpm |
| Impute missing genotypes | imp imp_avg imp_cnd |
| Calculate Z-scores from P-values and estimated effects | zsc |
