Package: ToxCrit 1.0
Lisa-Marie Lanz
ToxCrit: Calculates Safety Stopping Boundaries for a Single-Arm Trial using Bayes
Computation of stopping boundaries for a single-arm trial using a Bayesian criterion; i.e., for each m<=n (n= total patient number of the trial) the smallest number of observed toxicities is calculated leading to the termination of the trial/accrual according to the specified criteria. The probabilities of stopping the trial/accrual at and up until (resp.) the m-th patient (m<=n) is also calculated. This design is more conservative than the frequentist approach (using Clopper Pearson CIs) which might be preferred as it concerns safety.See also Aamot et.al.(2010) "Continuous monitoring of toxicity in clinical trials - simulating the risk of stopping prematurely" <doi:10.5414/cpp48476>.
Authors:
ToxCrit_1.0.tar.gz
ToxCrit_1.0.tar.gz(r-4.5-noble)ToxCrit_1.0.tar.gz(r-4.4-noble)
ToxCrit_1.0.tgz(r-4.4-emscripten)ToxCrit_1.0.tgz(r-4.3-emscripten)
ToxCrit.pdf |ToxCrit.html✨
ToxCrit/json (API)
# Install 'ToxCrit' in R: |
install.packages('ToxCrit', repos = c('https://cran.r-universe.dev', 'https://cloud.r-project.org')) |
This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.
Last updated 3 years agofrom:4b1c5396fb. Checks:OK: 2. Indexed: yes.
Target | Result | Date |
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Doc / Vignettes | OK | Nov 03 2024 |
R-4.5-linux | OK | Nov 03 2024 |
Exports:ToxCrit
Dependencies:
Readme and manuals
Help Manual
Help page | Topics |
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ToxCrit | ToxCrit |