Package: ReAD 1.0.1

Yan Li

ReAD: Powerful Replicability Analysis of Genome-Wide Association Studies

A robust and powerful approach is developed for replicability analysis of two Genome-wide association studies (GWASs) accounting for the linkage disequilibrium (LD) among genetic variants. The LD structure in two GWASs is captured by a four-state hidden Markov model (HMM). The unknowns involved in the HMM are estimated by an efficient expectation-maximization (EM) algorithm in combination with a non-parametric estimation of functions. By incorporating information from adjacent locations via the HMM, this approach identifies the entire clusters of genotype-phenotype associated signals, improving the power of replicability analysis while effectively controlling the false discovery rate.

Authors:Yan Li [aut, cre, cph], Haochen lei [aut], Xiaoquan Wen [aut], Hongyuan Cao [aut]

ReAD_1.0.1.tar.gz
ReAD_1.0.1.tar.gz(r-4.7-arm64)ReAD_1.0.1.tar.gz(r-4.7-x86_64)ReAD_1.0.1.tar.gz(r-4.6-arm64)ReAD_1.0.1.tar.gz(r-4.6-x86_64)
ReAD_1.0.1.tgz(r-4.6-emscripten)
manual.pdf |manual.html
card.svg |card.png
ReAD/json (API)

# Install 'ReAD' in R:
install.packages('ReAD', repos = c('https://cran.r-universe.dev', 'https://cloud.r-project.org'))
Uses libs:
  • openblas– Optimized BLAS
  • c++– GNU Standard C++ Library v3
  • openmp– GCC OpenMP (GOMP) support library

On CRAN:

Conda:

This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.

openblascppopenmp

2.51 score 325 scripts 328 downloads 3 exports 25 dependencies

Last updated from:ded0a60a71. Checks:4 NOTE, 2 OK. Indexed: yes.

TargetResultTimeFilesSyslog
linux-devel-arm64NOTE130
linux-devel-x86_64NOTE133
source / vignettesOK181
linux-release-arm64NOTE131
linux-release-x86_64NOTE137
wasm-releaseOK114

Exports:em_hmmReADSimuData

Dependencies:clicpp11farverggplot2gluegtableisobandlabelinglifecyclemagrittrplyrqvalueR6RColorBrewerRcppRcppArmadilloreshape2rlangS7scalesstringistringrvctrsviridisLitewithr