Package: Phase12Compare 1.5

Andrew G Chapple

Phase12Compare: Simulates SPSO and Efftox Phase 12 Trials with Correlated Outcomes

Simulating and conducting four phase 12 clinical trials with correlated binary bivariate outcomes described. Uses the 'Efftox' (efficacy and toxicity tradeoff, <https://biostatistics.mdanderson.org/SoftwareDownload/SingleSoftware/Index/2>) and SPSO (Semi-Parametric Stochastic Ordering) models with Utility and Desirability based objective functions for dose finding.

Authors:Andrew G Chapple

Phase12Compare_1.5.tar.gz
Phase12Compare_1.5.tar.gz(r-4.5-noble)Phase12Compare_1.5.tar.gz(r-4.4-noble)
Phase12Compare_1.5.tgz(r-4.4-emscripten)Phase12Compare_1.5.tgz(r-4.3-emscripten)
Phase12Compare.pdf |Phase12Compare.html✨
Phase12Compare/json (API)

# Install 'Phase12Compare' in R:

install.packages('Phase12Compare', repos = c('https://cran.r-universe.dev', 'https://cloud.r-project.org'))

Uses libs:

c++– GNU Standard C++ Library v3

This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.

1.00 score 176 downloads 17 exports 3 dependencies

Last updated 4 years agofrom:35dae94483. Checks:OK: 1 NOTE: 1. Indexed: yes.

Target	Result	Date
Doc / Vignettes	OK	Oct 31 2024
R-4.5-linux-x86_64	NOTE	Oct 31 2024

Exports:AssignEffTox AssignEffToxUT GETBIN GetDesire GetEfftoxContour GetEfftoxUt GetPriorsSPSO GetSpsoContour GetSpsoUt ReturnOpt RunAdaptiveEffToxTrialCORR RunAdaptiveEffToxTrialCORRCONTOUR SimEfftoxContour SimEfftoxUt SimSpsoContour SimSpsoUt UTEFFTOX

Dependencies:mvtnorm Rcpp RcppArmadillo

Citation

Readme and manuals

Help Manual

Help page	Topics
Determines the optimal dose to assign the next patient cohort.	AssignEffTox
Determines the optimal dose to assign the next patient cohort.	AssignEffToxUT
Generate binary bivariate data.	GETBIN
Returns the desireability value of a dose.	GetDesire
Assigns next patient cohort based on the Efftox model with a Desirability based objective function.	GetEfftoxContour
Assigns next patient cohort based on the Efftox model with a Utility based objective function.	GetEfftoxUt
Returns prior dose-specific means and prior ESS for the SPSO model.	GetPriorsSPSO
Assigns next patient cohort based on the SPSOP model with a Utility based objective function.	GetSpsoContour
Assigns next patient cohort based on the SPSOP model with a Utility based objective function.	GetSpsoUt
Obtains optimal dose level.	ReturnOpt
Simulates utility based Efftox trials	RunAdaptiveEffToxTrialCORR
Simulates desirability based Efftox trials	RunAdaptiveEffToxTrialCORRCONTOUR
Simulates trial replications from the Efftox model with desirability optimality function.	SimEfftoxContour
Simulates trial replications from the Efftox model with utility optimality function.	SimEfftoxUt
Simulates trial replications from the SPSO model with desirability optimality function.	SimSpsoContour
Simulates trial replications from the SPSO model with desirability optimality function.	SimSpsoUt
Samples from the posterior of the utility based phase12 model.	UTEFFTOX

Package: Phase12Compare 1.5

Phase12Compare: Simulates SPSO and Efftox Phase 12 Trials with Correlated Outcomes

Citation

Readme and manuals

Help Manual

Usage by other packages (reverse dependencies)