Package: OneArm2stage 1.2.1

Xiaomeng Yuan

OneArm2stage: Phase II Single-Arm Two-Stage Designs with Time-to-Event Outcomes

Two-stage design for single-arm phase II trials with time-to-event endpoints (e.g., clinical trials on immunotherapies among cancer patients) can be calculated using this package. Two notable advantages of the package: 1) It provides flexible choices from three design methods (optimal, minmax, and admissible), and 2) the power of the design is more accurately calculated using the exact variance in the one-sample log-rank test. The package can be used for 1) planning the sample sizes and other design parameters, and 2) conducting the interim and final analyses for the Go/No-go decisions. More details about the design method can be found in: Wu, J, Chen L, Wei J, Weiss H, Chauhan A. (2020). <doi:10.1002/pst.1983>.

Authors:Xiaomeng Yuan [aut, cre], Haitao Pan [aut], Jianrong Wu [aut]

OneArm2stage_1.2.1.tar.gz
OneArm2stage_1.2.1.tar.gz(r-4.5-noble)OneArm2stage_1.2.1.tar.gz(r-4.4-noble)
OneArm2stage_1.2.1.tgz(r-4.4-emscripten)OneArm2stage_1.2.1.tgz(r-4.3-emscripten)
OneArm2stage.pdf |OneArm2stage.html✨
OneArm2stage/json (API)
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Last updated 11 months agofrom:430a3c079d. Checks:OK: 2. Indexed: yes.

Exports:FitDatLRTphase2.TTESim

Dependencies:assertthatbbmlebdsmatrixBHbmpclicolorspacecpp11data.tabledeSolvedplyrfansifarverfastGHQuadflexsurvgenericsggplot2gluegridExtragtableIPDfromKMisobandjpeglabelinglatticelifecyclemagrittrMASSMatrixmgcvmstatemuhazmunsellmvtnormnlmenumDerivpillarpkgconfigpngpurrrquadprogR6RColorBrewerRcppRcppArmadilloreadbitmaprlangrstpm2scalesstatmodstringistringrsurvivaltibbletidyrtidyselecttiffutf8vctrsviridisLitewithr