Package: MAMS 3.0.3

Thomas Jaki

MAMS: Designing Multi-Arm Multi-Stage Studies

Designing multi-arm multi-stage studies with (asymptotically) normal endpoints and known variance.

Authors:Thomas Jaki [aut, cre], Dominique-Laurent Couturier [aut], Dominic Magirr [aut], Nikita Mozgunov [aut], Philip Pallmann [aut]

# Install 'MAMS' in R:

install.packages('MAMS', repos = c('https://cran.r-universe.dev', 'https://cloud.r-project.org'))

On CRAN:

Last updated from:9b606ea959. Checks:10 OK. Indexed: yes.

Target	Result	Time
linux-devel-arm64	OK	125
linux-devel-x86_64	OK	140
source / vignettes	OK	201
linux-release-arm64	OK	117
linux-release-x86_64	OK	116
windows-devel-arm64	OK	221
windows-devel-x86_64	OK	116
windows-release-arm64	OK	229
windows-release-x86_64	OK	91
wasm-release	OK	114

Help page	Topics
.onAttach	.onAttach
Function to design multi-arm multi-stage studies with normal endpoints	a and boundaries boundary determines finds for function given MAMS mams multi-arm multi-stage number of required shape study subjects. The the
Simulating multi-arm multi-stage designs	mams.sim
Shows changes and news	MAMSNews
Function to update boundaries based on observed sample sizes	new.bounds
Function to design multi-arm multi-stage studies with ordinal or binary endpoints	ordinal.mams
Plot method for MAMS objects	plot.MAMS
Plot method for MAMS.stepdown objects	plot.MAMS.stepdown
Generic print function for class MAMS.	print.MAMS
Generic print function for class MAMS.stepdown.	print.MAMS.stepdown
Function to find stopping boundaries for a 2- or 3-stage (step-down) multiple-comparisons-with-control test.	stepdown.mams
Update the stopping boundaries of multi-arm multi-stage study at an interim analysis, allowing for unplanned treatment selection and/or sample-size reassessment.	stepdown.update
Generic summary function for class MAMS.	summary.MAMS
Generic summary function for class MAMS.stepdown.	summary.MAMS.stepdown
Function to design multi-arm multi-stage studies with time-to-event endpoints	tite.mams