Package: GEVACO 1.0.1

Sydney Manning

GEVACO: Joint Test of Gene and GxE Interactions via Varying Coefficients

A novel statistical model to detect the joint genetic and dynamic gene-environment (GxE) interaction with continuous traits in genetic association studies. It uses varying-coefficient models to account for different GxE trajectories, regardless whether the relationship is linear or not. The package includes one function, GxEtest(), to test a single genetic variant (e.g., a single nucleotide polymorphism or SNP), and another function, GxEscreen(), to test for a set of genetic variants. The method involves a likelihood ratio test described in Crainiceanu, C. M., and Ruppert, D. (2004) <doi:10.1111/j.1467-9868.2004.00438.x>.

Authors:Zhengyang Zhou [aut] Sydney Manning [aut, cre] Chao Xing [aut] Hung-Chih Ku [aut]

GEVACO_1.0.1.tar.gz
GEVACO_1.0.1.tar.gz(r-4.5-noble)GEVACO_1.0.1.tar.gz(r-4.4-noble)
GEVACO_1.0.1.tgz(r-4.4-emscripten)GEVACO_1.0.1.tgz(r-4.3-emscripten)
GEVACO.pdf |GEVACO.html✨
GEVACO/json (API)

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2 exports 0.00 score 12 dependencies 2 scripts 286 downloads

Last updated 3 years agofrom:dc0079dfbd. Checks:OK: 1 WARNING: 1. Indexed: yes.

Exports:GxEscreenGxEtest

Dependencies:bootlatticelme4MASSMatrixmgcvminqanlmenloptrRcppRcppEigenRLRsim