Package: GEVACO 1.0.1

Sydney Manning

GEVACO: Joint Test of Gene and GxE Interactions via Varying Coefficients

A novel statistical model to detect the joint genetic and dynamic gene-environment (GxE) interaction with continuous traits in genetic association studies. It uses varying-coefficient models to account for different GxE trajectories, regardless whether the relationship is linear or not. The package includes one function, GxEtest(), to test a single genetic variant (e.g., a single nucleotide polymorphism or SNP), and another function, GxEscreen(), to test for a set of genetic variants. The method involves a likelihood ratio test described in Crainiceanu, C. M., and Ruppert, D. (2004) <doi:10.1111/j.1467-9868.2004.00438.x>.

Authors:Zhengyang Zhou [aut] Sydney Manning [aut, cre] Chao Xing [aut] Hung-Chih Ku [aut]

GEVACO_1.0.1.tar.gz
GEVACO_1.0.1.tar.gz(r-4.5-noble)GEVACO_1.0.1.tar.gz(r-4.4-noble)
GEVACO_1.0.1.tgz(r-4.4-emscripten)GEVACO_1.0.1.tgz(r-4.3-emscripten)
GEVACO.pdf |GEVACO.html✨
GEVACO/json (API)

# Install 'GEVACO' in R:
install.packages('GEVACO', repos = c('https://cran.r-universe.dev', 'https://cloud.r-project.org'))
Datasets:

On CRAN:

Conda-Forge:

This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.

2.00 score 2 scripts 218 downloads 2 exports 15 dependencies

Last updated 3 years agofrom:dc0079dfbd. Checks:1 OK, 1 WARNING. Indexed: yes.

TargetResultLatest binary
Doc / VignettesOKFeb 24 2025
R-4.5-linuxWARNINGFeb 24 2025

Exports:GxEscreenGxEtest

Dependencies:bootlatticelme4MASSMatrixmgcvminqanlmenloptrrbibutilsRcppRcppEigenRdpackreformulasRLRsim

GEVACO Introduction

| Sydney Manning | Department of Pharmacotherapy | University of North Texas Health Science Center -- Fort Worth

Rendered fromGEVACO_Intro.Rmdusingknitr::rmarkdownon Feb 24 2025.

Last update: 2021-12-10
Started: 2020-12-03