Package: mmrm 0.3.12
![](https://r-universe.dev/static/nobody.jpg)
Daniel Sabanes Bove
mmrm:Mixed Models for Repeated Measures
Mixed models for repeated measures (MMRM) are a popular choice for analyzing longitudinal continuous outcomes in randomized clinical trials and beyond; see Cnaan, Laird and Slasor (1997) <doi:10.1002/(SICI)1097-0258(19971030)16:20%3C2349::AID-SIM667%3E3.0.CO;2-E> for a tutorial and Mallinckrodt, Lane, Schnell, Peng and Mancuso (2008) <doi:10.1177/009286150804200402> for a review. This package implements MMRM based on the marginal linear model without random effects using Template Model Builder ('TMB') which enables fast and robust model fitting. Users can specify a variety of covariance matrices, weight observations, fit models with restricted or standard maximum likelihood inference, perform hypothesis testing with Satterthwaite or Kenward-Roger adjustment, and extract least square means estimates by using 'emmeans'.
Authors:
mmrm_0.3.12.tar.gz
mmrm_0.3.12.tar.gz(r-4.5-noble)mmrm_0.3.12.tar.gz(r-4.4-noble)
mmrm.pdf |mmrm.html✨
mmrm/json (API)
NEWS
# Installmmrm in R: |
install.packages('mmrm',repos = c('https://cran.r-universe.dev', 'https://cloud.r-project.org')) |
Bug tracker:https://github.com/openpharma/mmrm/issues
Last updated 9 days agofrom:bf2bbd36ab
Exports:as.cov_structaugmentcomponentcov_structcov_typesdf_1ddf_mdemp_startfit_mmrmfit_single_optimizerglancemmrmmmrm_controlrefit_multiple_optimizersstd_starttidyVarCorr
Dependencies:backportsbriocallrcheckmateclicrayondescdiffobjdigestevaluatefansifsgenericsgluejsonlitelatticelifecyclemagrittrMatrixnlmepillarpkgbuildpkgconfigpkgloadpraiseprocessxpsR6rbibutilsRcppRcppEigenRdpackrematch2rlangrprojrootstringistringrtestthattibbleTMButf8vctrswaldowithr
Between-Within
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usingknitr::rmarkdown
on Jun 27 2024.Last update: 2023-11-18
Started: 2023-11-18
Coefficients Covariance Matrix Adjustment
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usingknitr::rmarkdown
on Jun 27 2024.Last update: 2024-01-25
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Comparison with other software
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usingknitr::rmarkdown
on Jun 27 2024.Last update: 2024-01-25
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Covariance Structures
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usingknitr::rmarkdown
on Jun 27 2024.Last update: 2023-11-18
Started: 2022-10-18
Details of Hypothesis Testing
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usingknitr::rmarkdown
on Jun 27 2024.Last update: 2024-01-25
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Details of Weighted Least Square Empirical Covariance
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usingknitr::rmarkdown
on Jun 27 2024.Last update: 2024-06-27
Started: 2023-11-18
Kenward-Roger
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usingknitr::rmarkdown
on Jun 27 2024.Last update: 2023-11-18
Started: 2022-12-20
Mixed Models for Repeated Measures
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usingknitr::rmarkdown
on Jun 27 2024.Last update: 2023-11-18
Started: 2023-11-18
Model Fitting Algorithm
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usingknitr::rmarkdown
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Package Introduction
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usingknitr::rmarkdown
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Package Structure
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usingknitr::rmarkdown
on Jun 27 2024.Last update: 2024-01-25
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Prediction and Simulation
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usingknitr::rmarkdown
on Jun 27 2024.Last update: 2024-01-25
Started: 2023-11-18
Satterthwaite
Rendered fromsatterthwaite.Rmd
usingknitr::rmarkdown
on Jun 27 2024.Last update: 2023-11-18
Started: 2022-12-20