Package: wnl
Version: 0.8.5
Title: Minimization Tool for Pharmacokinetic-Pharmacodynamic Data
        Analysis
Description: This is a set of minimization tools (maximum likelihood
        estimation and least square fitting) to solve examples in the
        Johan Gabrielsson and Dan Weiner's book "Pharmacokinetic and
        Pharmacodynamic Data Analysis - Concepts and Applications" 5th
        ed. (ISBN:9198299107). Examples include linear and nonlinear
        compartmental model, turn-over model, single or multiple dosing
        bolus/infusion/oral models, allometry, toxicokinetics,
        reversible metabolism, in-vitro/in-vivo extrapolation,
        enterohepatic circulation, metabolite modeling, Emax model,
        inhibitory model, tolerance model, oscillating response model,
        enantiomer interaction model, effect compartment model,
        drug-drug interaction model, receptor occupancy model, and
        rebound phenomena model.
Depends: R (>= 3.5.0), numDeriv
Authors@R: person(given="Kyun-Seop", family="Bae", role=c("aut", "cre", "cph"), email="k@acr.kr")
Author: Kyun-Seop Bae [aut, cre, cph]
Maintainer: Kyun-Seop Bae <k@acr.kr>
Copyright: 2017-, Kyun-Seop Bae
License: GPL-3
NeedsCompilation: no
LazyLoad: yes
URL: https://cran.r-project.org/package=wnl
Packaged: 2026-07-08 05:38:20 UTC; root
Repository: https://cran.r-universe.dev
Date/Publication: 2026-03-07 16:46:42 UTC
RemoteUrl: https://github.com/cran/wnl
RemoteRef: HEAD
RemoteSha: 3abddf1d87525f6b249cd27d1ce80d27008f60c3