# -------------------------------------------- # CITATION file created with {cffr} R package # See also: https://docs.ropensci.org/cffr/ # -------------------------------------------- cff-version: 1.2.0 message: 'To cite package "twoPhaseGAS" in publications use:' type: software license: GPL-2.0-or-later title: 'twoPhaseGAS: Two-Phase Genetic Association Study Design and Analysis with Missing Covariates by Design' version: 1.2.5 abstract: Provides functionality for designing and analysing two-phase genetic association studies. Phase 1 data usually come from genome-wide association study (GWAS) results and we assume phase 2 data will be part of a targeted genome sequencing or fine-mapping study. At design stage, the package assists in selecting a subset of individuals that will be sequenced for phase 2 via alternative approaches, including a flexible genetic algorithm (GA) for near-optimal designs. Once phase 2 data have been collected, the package implements methods to analyse phase 1 and phase 2 data together using semi-parametric regression models via the expectation-maximization (EM) algorithm. For more details see Espin-Garcia, Craiu and Bull (2018) and Espin-Garcia, Craiu and Bull (2021) . authors: - family-names: Espin-Garcia given-names: Osvaldo email: oespinga@uwo.ca - family-names: Dimitromanolakis given-names: Apostolos email: apostolis@live.ca repository: https://cran.r-universe.dev repository-code: https://github.com/egosv/twoPhaseGAS commit: 5f85bc43c06f44e49f413af5418eca64eb5bb4d9 url: https://github.com/egosv/twoPhaseGAS date-released: '2026-05-27' contact: - family-names: Espin-Garcia given-names: Osvaldo email: oespinga@uwo.ca