Package: ttScreening
Title: Genome-Wide DNA Methylation Sites Screening by Use of Training
        and Testing Samples
Version: 1.8
Authors@R: 
    c(person(given="Meredith", family="Ray", email="maray@memphis.edu", role = c("aut", "cre")),
    person(given="Mohammad Nahian Ferdous", family="Abrar", email="abrar0708@gmail.com",role=c("aut")), person(given="Yu", family="Jiang", role = c("aut")),person(given="Xin", family="Tong", role = c("aut")), person(given="Hongmei", family="Zhang", role = c("aut")))
Description: A screening process utilizing training and testing samples
        to filter out uninformative DNA methylation sites. Surrogate
        variables (SVs) of DNA methylation are included in the
        filtering process to explain unknown factor effects. This
        package also provides two screening functions for screening
        high-dimensional predictors when the events are rare. The firth
        method is called 'Rare-Screening' which employs a repeated
        random sampling with replacement and using linear modeling with
        Bayes adjustment. The Second method is called
        'Firth-ttScreening' which uses 'ttScreening' method with
        additional Firth correction term in the maximum likelihood for
        the logistic regression model. These methods handle the
        high-dimensionality and low event rates.
License: Artistic-2.0
Encoding: UTF-8
RoxygenNote: 7.3.3
Depends: matrixStats,sva,limma
Imports: graphics,stats,corpcor,simsalapar,MASS,brglm2
biocViews:
Suggests: mvtnorm
NeedsCompilation: no
Packaged: 2026-07-19 05:47:08 UTC; root
Author: Meredith Ray [aut, cre], Mohammad Nahian Ferdous Abrar [aut],
        Yu Jiang [aut], Xin Tong [aut], Hongmei Zhang [aut]
Maintainer: Meredith Ray <maray@memphis.edu>
Config/pak/sysreqs: zlib1g-dev
Repository: https://cran.r-universe.dev
Date/Publication: 2026-01-30 17:50:02 UTC
RemoteUrl: https://github.com/cran/ttScreening
RemoteRef: HEAD
RemoteSha: 7b199c76ef113c24a15c00544bd579414eba5e66