Package: refreg
Type: Package
Title: Conditional Multivariate Reference Regions
Version: 0.1.1
Authors@R: c(
    person("Oscar", "Lado-Baleato",email="oscarlado.baleato@usc.es", role =c("cre","aut")),
    person("Javier", "Roca-Pardinas", email="roca@uvigo.es", role =c("aut", "ctb")),
    person("Carmen", "Cadarso-Suarez",email="carmen.cadarso@usc.es", role = c("aut", "ths")),
    person("Gude","Francisco",email="francisco.gude.sampedro@sergas.es", role = c("aut", "ths"))
    )
Maintainer: Oscar Lado-Baleato <oscarlado.baleato@usc.es>
Description: An R package for estimating conditional multivariate
        reference regions. The reference region is non parametrically
        estimated using a kernel density estimator. Covariates effects
        on the multivariate response means vector and
        variance-covariance matrix, thus on the region shape, are
        estimated by flexible additive predictors. Continuous
        covariates non linear effects might be estimated using
        penalized splines smoothers. Confidence intervals for the
        covariates estimated effects might be derived from bootstrap
        resampling. Kernel density bandwidth can be estimated with
        different methods, including a method that optimize the region
        coverage. Numerical, and graphical, summaries can be obtained
        by the user in order to evaluate reference region performance
        with real data. Full mathematical details can be found in
        <doi:10.1002/sim.9163> and <doi:10.1007/s00477-020-01901-1>.
Imports:
        ks,KernSmooth,mgcv,gridExtra,ggplot2,RColorBrewer,sp,stringr,foreach,doParallel,pracma,misc3d,rgl,mbend,matrixcalc,methods
License: GPL-2
Encoding: UTF-8
LazyData: true
RoxygenNote: 7.1.2
Depends: R (>= 2.10)
NeedsCompilation: no
Packaged: 2026-09-30 11:29:11 UTC; root
Author: Oscar Lado-Baleato [cre, aut], Javier Roca-Pardinas [aut, ctb],
        Carmen Cadarso-Suarez [aut, ths], Gude Francisco [aut, ths]
Repository: https://cran.r-universe.dev
Date/Publication: 2022-04-18 13:20:02 UTC
RemoteUrl: https://github.com/cran/refreg
RemoteRef: HEAD
RemoteSha: 40eed0780ac588c843ccce5926f10beb4fed6d3b