Type: Package
Package: refineR
Version: 2.0.0
Date: 2025-11-05
Encoding: UTF-8
Title: Reference Interval Estimation using Real-World Data
Author: Matthias Beck [aut, cre] (ORCID:
        <https://orcid.org/0009-0008-7678-4581>), Tatjana Ammer [aut]
        (ORCID: <https://orcid.org/0000-0003-2809-0266>), Christopher M
        Rank [aut], Andre Schuetzenmeister [aut] (ORCID:
        <https://orcid.org/0000-0002-2964-5502>)
Maintainer: Matthias Beck <matthias.beck.mb1@roche.com>
Authors@R: c(
    person(given ="Matthias", family = "Beck", email ="matthias.beck.mb1@roche.com", role =c("aut", "cre"), comment = c(ORCID = "0009-0008-7678-4581")),
	person(given ="Tatjana", family ="Ammer", email ="tatjana.ammer@roche.com", role ="aut", comment = c(ORCID = "0000-0003-2809-0266")),
	person(given ="Christopher M", family = "Rank", email ="christopher.rank@roche.com", role ="aut", comment = c(ORCID = "")),
	person(given ="Andre", family ="Schuetzenmeister", email ="andre.schuetzenmeister@roche.com", role ="aut", comment = c(ORCID = "0000-0002-2964-5502")))
Depends: R (>= 3.2.0)
Imports: stats, ash, future, future.apply, parallel, graphics,
        grDevices
Suggests: knitr, rmarkdown
Description: Indirect method for the estimation of reference intervals
        (RIs) using Real-World Data ('RWD') and methods for comparing
        and verifying RIs. Estimates RIs by applying advanced
        statistical methods to routine diagnostic test measurements,
        which include both pathological and non-pathological samples,
        to model the distribution of non-pathological samples. This
        distribution is then used to derive reference intervals and
        support RI verification, i.e., deciding if a specific RI is
        suitable for the local population. The package also provides
        functions for printing and plotting algorithm results. See
        ?refineR for a detailed description of features. Version 1.0 of
        the algorithm is described in 'Ammer et al. (2021)'
        <doi:10.1038/s41598-021-95301-2>. Additional guidance is in
        'Ammer et al. (2023)' <doi:10.1093/jalm/jfac101>. The
        verification method is described in 'Beck et al. (2025)'
        <doi:10.1515/cclm-2025-0728>.
License: GPL (>= 3)
VignetteBuilder: knitr, rmarkdown
NeedsCompilation: no
LazyData: TRUE
RoxygenNote: 7.3.2
Packaged: 2026-07-04 06:41:11 UTC; root
Repository: https://cran.r-universe.dev
Date/Publication: 2025-11-06 17:20:02 UTC
RemoteUrl: https://github.com/cran/refineR
RemoteRef: HEAD
RemoteSha: 0592f142c7c51d2b5d3ce703d016d1c9f5b7de84