Package: progme Type: Package Title: Extended Progression Models for Repeated Measures Version: 0.1.0 Authors@R: c( person("Mukul", "Bijalwan", email = "mukulbijalwan555@gmail.com", role = c("aut", "cre"), comment = c(ORCID = "0009-0001-3040-6912")), person("Gunjan", "Aggrwal", role = "aut"), person("Mukul", "Jain", role = "aut")) Description: Extended progression models for repeated measures in progressive disease clinical trials. Provides nonlinear mixed-effects progression models (linear, plateau, Emax, exponential decay), delayed treatment onset estimation by profile likelihood, joint longitudinal-survival models for informative dropout, competing-risks extensions, biomarker-informed adaptive dosing rules, and simulation-based power and sample-size calculation. The progression-model view of treatment effects, in which effects are characterised on the underlying disease trajectory rather than as additive shifts on the outcome scale, follows Raket (2022) . The nonlinear mixed-effects machinery is built on the 'nlme' implementation described by Pinheiro and Bates (2000, ISBN 978-0-387-98957-0), and the joint modelling of longitudinal and time-to-event data follows Rizopoulos (2012, ISBN 978-1-4398-7286-4). License: GPL (>= 3) Encoding: UTF-8 LazyData: true Depends: R (>= 4.1.0) Imports: nlme, survival, ggplot2, stats, graphics, utils Suggests: rstan, testthat (>= 3.0.0), knitr, rmarkdown VignetteBuilder: knitr Config/testthat/edition: 3 URL: https://github.com/MukulBijalwan/progme BugReports: https://github.com/MukulBijalwan/progme/issues Config/roxygen2/version: 8.1.0 NeedsCompilation: no Packaged: 2026-10-22 15:39:52 UTC; root Author: Mukul Bijalwan [aut, cre] (ORCID: ), Gunjan Aggrwal [aut], Mukul Jain [aut] Maintainer: Mukul Bijalwan Repository: https://cran.r-universe.dev Date/Publication: 2026-10-22 10:30:09 UTC RemoteUrl: https://github.com/cran/progme RemoteRef: HEAD RemoteSha: 75ba93ebdccb5e03957c219c82d920ec4d1c14d1