General-purpose helpers for NONMEM dataset construction added (build_nm_dataset, build_dose_records, build_obs_records).
Time-varying covariate merge by LOCF/LOCB: locf_value, merge_cov_locf.
Datetime parsers: parse_dtc, dat2_time_to_posix.
Coding helpers: code_sex, code_race.
Cockcroft-Gault CRCL: crcl_cg, add_crcl_cg.
Mass to molar unit conversion: nm_to_molar.
Post-run processing of NONMEM output with PDF diagnostic reports merged from nma package.
8 report types: OFV, Parameters, Predictions, Residuals, EBE, Input, Output, IndiPK.
New utility functions for NONMEM data processing and parsing.
Switched from exportPattern to explicit exports in NAMESPACE.
Typos in documentation corrected.
AddCox function for adding a covariate to existing NONMEM dataset.
CombDmExPc function for combining demographics(DM), dosing(EX), and DV(PC) tables.
TrimOut function to beautify the original NONMEM OUTPUT
Errata in manual corrected.
Errata in manual corrected.
TabStep() is added.
Speed is increased.
References are updated.
Vignette is updated.
This package will be used at the workshop on 2017-10-25 at Kyoto Japan 1st APC satellite workshop.
Bug at calculating objective function value for "LAPL" method is fixed.
Bug at scaling other than zero lower bound transformation fixed.
This package will be used at the workshop within US FDA on 2017-03-21.
For the initialization step, Pred function name should be given by the user. It does not read directly from the file any more.
This package was born and used at the Workshop held by Kyun-Seop Bae MD PhD <[email protected]>.
InitStep used Pred function within a file.