Package 'ncar' reference manual

Title:	Noncompartmental Analysis for Pharmacokinetic Report
Description:	Conduct a noncompartmental analysis with industrial strength. Some features are 1) CDISC SDTM terms 2) Automatic or manual slope selection 3) Supporting both 'linear-up linear-down' and 'linear-up log-down' method 4) Interval(partial) AUCs with 'linear' or 'log' interpolation method 5) Produce pdf, rtf, text report files. * Reference: Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016. (ISBN:9198299107).
Authors:	Kyun-Seop Bae [aut]
Maintainer:	Kyun-Seop Bae <[email protected]>
License:	GPL-3
Version:	0.5.0
Built:	2024-12-14 06:27:20 UTC
Source:	CRAN

Noncompartmental Analysis for Pharmacokinetic Report

Description

It can report a noncompartmental analysis (NCA) with industrial strength.

Details

The main functions are

pdfNCA to produce PDF file format NCA.
rtfNCA to produce rtf file format NCA.

Author(s)

Kyun-Seop Bae <[email protected]>

References

Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016.
Shargel L, Yu A. Applied Biopharmaceutics and Pharmacokinetics. 7th ed. 2015.
Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics - Concepts and Applications. 4th ed. 2011.
Gibaldi M, Perrier D. Pharmacokinetics. 2nd ed. revised and expanded. 1982.

Examples

# Theoph and Indometh data: dose in mg, conc in mg/L, time in h

# Output to PDF file
#pdfNCA(fileName="NCA-Theoph.pdf", Theoph, key="Subject", colTime="Time",
#       colConc="conc", dose=320, doseUnit="mg", timeUnit="h", concUnit="mg/L")
#pdfNCA(fileName="NCA-Theoph.pdf", Theoph, key=c("Subject", "Wt"), colTime="Time",
#       colConc="conc", dose=320, doseUnit="mg", timeUnit="h", concUnit="mg/L")
#pdfNCA(fileName="NCA-Indometh.pdf", Indometh, key="Subject", colTime="time",
#       colConc="conc", adm="Infusion", dur=0.5, dose=25, doseUnit="mg",
#       timeUnit="h", concUnit="mg/L")


# Output to RTF file
#rtfNCA(fileName="NCA-Theoph.rtf", Theoph, key="Subject", colTime="Time",
#       colConc="conc", dose=320, doseUnit="mg", timeUnit="h", concUnit="mg/L")
#rtfNCA(fileName="NCA-Theoph.rtf", Theoph, key=c("Subject", "Wt"), colTime="Time",
#       colConc="conc", dose=320, doseUnit="mg", timeUnit="h", concUnit="mg/L")
#rtfNCA(fileName="NCA-Indometh.rtf", Indometh, key="Subject", colTime="time",
#       colConc="conc", adm="Infusion", dur=0.5, dose=25, doseUnit="mg",
#       timeUnit="h", concUnit="mg/L")
# Theoph and Indometh data: dose in mg, conc in mg/L, time in h

# Output to PDF file
#pdfNCA(fileName="NCA-Theoph.pdf", Theoph, key="Subject", colTime="Time",
#       colConc="conc", dose=320, doseUnit="mg", timeUnit="h", concUnit="mg/L")
#pdfNCA(fileName="NCA-Theoph.pdf", Theoph, key=c("Subject", "Wt"), colTime="Time",
#       colConc="conc", dose=320, doseUnit="mg", timeUnit="h", concUnit="mg/L")
#pdfNCA(fileName="NCA-Indometh.pdf", Indometh, key="Subject", colTime="time",
#       colConc="conc", adm="Infusion", dur=0.5, dose=25, doseUnit="mg",
#       timeUnit="h", concUnit="mg/L")


# Output to RTF file
#rtfNCA(fileName="NCA-Theoph.rtf", Theoph, key="Subject", colTime="Time",
#       colConc="conc", dose=320, doseUnit="mg", timeUnit="h", concUnit="mg/L")
#rtfNCA(fileName="NCA-Theoph.rtf", Theoph, key=c("Subject", "Wt"), colTime="Time",
#       colConc="conc", dose=320, doseUnit="mg", timeUnit="h", concUnit="mg/L")
#rtfNCA(fileName="NCA-Indometh.rtf", Indometh, key="Subject", colTime="time",
#       colConc="conc", adm="Infusion", dur=0.5, dose=25, doseUnit="mg",
#       timeUnit="h", concUnit="mg/L")

NCA output to pdf file

Description

This output NCA result in a pdf file.

Usage

pdfNCA(fileName = "Temp-NCA.pdf", concData, key = "Subject", colTime = "Time", 
       colConc = "conc", dose = 0, adm = "Extravascular", dur = 0, 
       doseUnit = "mg", timeUnit = "h", concUnit = "ug/L", down="Linear", 
       R2ADJ = 0, MW = 0, SS = FALSE, iAUC = "", excludeDelta = 1)
pdfNCA(fileName = "Temp-NCA.pdf", concData, key = "Subject", colTime = "Time", 
       colConc = "conc", dose = 0, adm = "Extravascular", dur = 0, 
       doseUnit = "mg", timeUnit = "h", concUnit = "ug/L", down="Linear", 
       R2ADJ = 0, MW = 0, SS = FALSE, iAUC = "", excludeDelta = 1)

Arguments

`fileName`	file name to save
`concData`	concentration data table
`key`	column names of concData to be shown in the output table
`colTime`	column name for time
`colConc`	column name for concentration
`dose`	administered dose
`adm`	one of `"Bolus"` or `"Infusion"` or `"Extravascular"` to indicate drug administration mode
`dur`	duration of infusion
`doseUnit`	unit of dose
`timeUnit`	unit of time
`concUnit`	unit of concentration
`down`	either of `"Linear"` or `"Log"` to indicate the way to calculate AUC and AUMC
`R2ADJ`	Minimum adjusted R-square value to determine terminal slope automatically
`MW`	molecular weight of drug
`SS`	if steady-state, this should be TRUE. AUCLST (AUClast) is used instead of AUCIFO (AUCinf) for the calculation of Vz (VZFO, VZO), CL (CLFO, CLO), and Vdss (VSSO).
`iAUC`	interval AUC information in a dataframe with "Name", "Start", and "End" columns
`excludeDelta`	Improvement of R2ADJ larger than this value could exclude the last point. Default value 1 is for the compatibility with other software. Author recommends to use `excludeDelta` option with about 0.3.

Value

`CMAX`	maximum concentration, Cmax
`CMAXD`	dose normalized Cmax, CMAX / Dose, Cmax / Dose
`TMAX`	time of maximum concentration, Tmax
`TLAG`	time to observe the first non-zero concentration, for extravascular administration only
`CLST`	last positive concentration observed, Clast
`CLSTP`	last positive concentration predicted, Clast_pred
`TLST`	time of last positive concentration, Tlast
`LAMZHL`	half-life by lambda z, ln(2)/LAMZ
`LAMZ`	lambda_z negative of best fit terminal slope
`LAMZLL`	earliest time for LAMZ
`LAMZUL`	last time for LAMZ
`LAMZNPT`	number of points for LAMZ
`CORRXY`	correlation of log(concentration) and time
`R2`	R-squared
`R2ADJ`	R-squared adjusted
`C0`	back extrapolated concentration at time 0, for bolus intravascular administration only
`AUCLST`	AUC from 0 to TLST
`AUCALL`	AUC using all the given points, including trailing zero concentrations
`AUCIFO`	AUC infinity observed
`AUCIFOD`	AUCIFO / Dose
`AUCIFP`	AUC infinity predicted using CLSTP instead of CLST
`AUCIFPD`	AUCIFP / Dose
`AUCPEO`	AUC % extrapolation observed
`AUCPEP`	AUC % extrapolated for AUCIFP
`AUCPBEO`	AUC % back extrapolation observed, for bolus IV administration only
`AUCPBEP`	AUC % back extrapolation predicted with AUCIFP, for bolus IV administration only
`AUMCLST`	AUMC to the TLST
`AUMCIFO`	AUMC infinity observed using CLST
`AUMCIFP`	AUMC infinity determined by CLSTP
`AUMCPEO`	AUMC % extrapolated observed
`AUMCPEP`	AUMC % extrapolated predicted
`MRTIVLST`	mean residence time (MRT) to TLST, for intravascular administration
`MRTIVIFO`	mean residence time (MRT) infinity using CLST, for intravascular administration
`MRTIVIFP`	mean residence time (MRT) infinity using CLSTP, for intravascular administration
`MRTEVLST`	mean residence time (MRT) to TLST, for extravascular administration
`MRTEVIFO`	mean residence time (MRT) infinity using CLST, for extravascular administration
`MRTEVIFP`	mean residence time (MRT) infinity using CLSTP, for extravascular administration
`VZO`	volume of distribution determined by LAMZ and AUCIFO, for intravascular administration
`VZP`	volume of distribution determined by LAMZ and AUCIFP, for intravascular administration
`VZFO`	VZO for extravascular administration, VZO/F, F is bioavailability
`VZFP`	VZP for extravascular administration, VZP/F, F is bioavailability
`CLO`	clearance using AUCIFO, for intravascular administration
`CLP`	clearance using AUCIFP, for intravascular administration
`CLFO`	CLO for extravascular administration, CLO/F, F is bioavailability
`CLFP`	CLP for extravascular administration, CLP/F, F is bioavailability
`VSSO`	volume of distribution at steady state using CLST, for intravascular administration only
`VSSP`	volume of distribution at stead state using CLSTP, for intravascular administration only

Author(s)

Kyun-Seop Bae <[email protected]>

Examples

#pdfNCA(fileName="NCA-Theoph.pdf", Theoph, key="Subject", colTime="Time", 
#       colConc="conc", dose=320, doseUnit="mg", timeUnit="h", concUnit="mg/L")
#pdfNCA(fileName="NCA-Theoph.pdf", Theoph, key=c("Subject", "Wt"), colTime="Time",
#       colConc="conc", dose=320, doseUnit="mg", timeUnit="h", concUnit="mg/L")
#pdfNCA(fileName="NCA-Indometh.pdf", Indometh, key="Subject", colTime="time", 
#       colConc="conc", adm="Infusion", dur=0.5, dose=25, doseUnit="mg", 
#       timeUnit="h", concUnit="mg/L")
#pdfNCA(fileName="NCA-Theoph.pdf", Theoph, key="Subject", colTime="Time", 
#       colConc="conc", dose=320, doseUnit="mg", timeUnit="h", concUnit="mg/L")
#pdfNCA(fileName="NCA-Theoph.pdf", Theoph, key=c("Subject", "Wt"), colTime="Time",
#       colConc="conc", dose=320, doseUnit="mg", timeUnit="h", concUnit="mg/L")
#pdfNCA(fileName="NCA-Indometh.pdf", Indometh, key="Subject", colTime="time", 
#       colConc="conc", adm="Infusion", dur=0.5, dose=25, doseUnit="mg", 
#       timeUnit="h", concUnit="mg/L")

Convert sNCA output table to text form

Description

This converts the table output of sNCA to text form output.

Usage

Res2Txt(ResNCA, x, y, dose = 0, adm = "Extravascular", dur = 0, doseUnit = "mg", 
        down = "Linear")
Res2Txt(ResNCA, x, y, dose = 0, adm = "Extravascular", dur = 0, doseUnit = "mg", 
        down = "Linear")

Arguments

`ResNCA`	Output table from `sNCA`
`x`	usually time
`y`	usually concentration
`dose`	given amount
`adm`	one of `"Bolus"` or `"Infusion"` or `"Extravascular"` to indicate drug administration mode
`dur`	duration of infusion
`doseUnit`	unit of dose
`down`	either of `"Linear"` or `"Log"` to indicate the way to calculate AUC and AUMC

Value

Text form output from the coversion of table form output

Author(s)

Kyun-Seop Bae <[email protected]>

Examples

x = Theoph[Theoph$Subject=="1","Time"]
y = Theoph[Theoph$Subject=="1","conc"]
z = sNCA(x, y, dose=320, doseUnit="mg", concUnit="mg/L", timeUnit="h")
Res2Txt(z, x, y)  
x = Theoph[Theoph$Subject=="1","Time"]
y = Theoph[Theoph$Subject=="1","conc"]
z = sNCA(x, y, dose=320, doseUnit="mg", concUnit="mg/L", timeUnit="h")
Res2Txt(z, x, y)

Round Half Away from Zero

Description

This is an ordinary rounding function, so called round half away from zero

Usage

Round(x, n = 0)Round(x, n = 0)

Arguments

`x`	numeric to be rounded
`n`	indicating decimal digits

Details

The function round in R base rounds to the even number, i.e. round(0.5) is 0 not 1. If you want rounding 0.5 be 1, you can use this Round function. This function is for the consistency with other software like MS-Excel, SAS.

Value

ordinarily rounded value

Author(s)

Kyun-Seop Bae <[email protected]>

References

See wikipedia subject "Rounding"

Examples

(x = 1:10 - 0.5)
Round(x)
round(x) # compare with the above
(x = 1:10 - 0.5)
Round(x)
round(x) # compare with the above

NCA Report Configuation Table

Description

Contains the names and order of colum of return table/text in ouputs

Usage

RptCfgRptCfg

Format

A data frame with 48 observations on the following 10 variables.

PPTESTCD: a character vector of CDISC SDTM PPTESTCD
SYNONYM: a character vector of CDISC SDTM PPTESTCD Synonym
NCI: a character vector of NCI peferred terms
WNL: a character vector of WinNonlin(R) software variables
ExtravascularDefault: a numeric vector of ordering in report for extravascular administration, Zero means exclusion in the report.
ExtravascularWNL: a numeric vector of WinNonlin(R) style ordering in report for extravascular administration, Zero means exclusion in the report.
BolusDefault: a numeric vector of ordering in report for extravascular administration, Zero means exclusion in the report.
BolusWNL: a numeric vector of WinNonlin(R) style ordering in report for extravascular administration, Zero means exclusion in the report.
InfusionDefault: a numeric vector of ordering in report for extravascular administration, Zero means exclusion in the report.
InfusionWNL: a numeric vector of WinNonlin(R) style ordering in report for extravascular administration, Zero means exclusion in the report.

Details

This table should exist in this package.

NCA output to rtf file

Description

This output NCA result in a rtf file.

Usage

rtfNCA(fileName = "Temp-NCA.rtf", concData, key = "Subject", colTime = "Time", 
       colConc = "conc", dose = 0, adm = "Extravascular", dur = 0, 
       doseUnit = "mg", timeUnit = "h", concUnit = "ug/L", down="Linear", 
       R2ADJ = 0, MW = 0, SS = FALSE, iAUC = "", excludeDelta = 1)
rtfNCA(fileName = "Temp-NCA.rtf", concData, key = "Subject", colTime = "Time", 
       colConc = "conc", dose = 0, adm = "Extravascular", dur = 0, 
       doseUnit = "mg", timeUnit = "h", concUnit = "ug/L", down="Linear", 
       R2ADJ = 0, MW = 0, SS = FALSE, iAUC = "", excludeDelta = 1)

Arguments

`fileName`	file name to save
`concData`	concentration data table
`key`	column names of concData to be shown in the output
`colTime`	column name for time
`colConc`	column name for concentration
`dose`	administered dose
`adm`	one of `"Bolus"` or `"Infusion"` or `"Extravascular"` to indicate drug administration mode
`dur`	duration of infusion
`doseUnit`	unit of dose
`timeUnit`	unit of time
`concUnit`	unit of concentration
`down`	either of `"Linear"` or `"Log"` to indicate the way to calculate AUC and AUMC
`R2ADJ`	Minimum adjusted R-square value to determine terminal slope automatically
`MW`	molecular weight of drug
`SS`	if steady-state, this should be TRUE. AUCLST (AUClast) is used instead of AUCIFO (AUCinf) for the calculation of Vz (VZFO, VZO), CL (CLFO, CLO), and Vdss (VSSO).
`iAUC`	interval AUC information in a dataframe with "Name", "Start", and "End" columns
`excludeDelta`	Improvement of R2ADJ larger than this value could exclude the last point. Default value 1 is for the compatibility with other software. Author recommends to use `excludeDelta` option with about 0.3.

Value

`CMAX`	maximum concentration, Cmax
`CMAXD`	dose normalized Cmax, CMAX / Dose, Cmax / Dose
`TMAX`	time of maximum concentration, Tmax
`TLAG`	time to observe the first non-zero concentration, for extravascular administration only
`CLST`	last positive concentration observed, Clast
`CLSTP`	last positive concentration predicted, Clast_pred
`TLST`	time of last positive concentration, Tlast
`LAMZHL`	half-life by lambda z, ln(2)/LAMZ
`LAMZ`	lambda_z negative of best fit terminal slope
`LAMZLL`	earliest time for LAMZ
`LAMZUL`	last time for LAMZ
`LAMZNPT`	number of points for LAMZ
`CORRXY`	correlation of log(concentration) and time
`R2`	R-squared
`R2ADJ`	R-squared adjusted
`C0`	back extrapolated concentration at time 0, for bolus intravascular administration only
`AUCLST`	AUC from 0 to TLST
`AUCALL`	AUC using all the given points, including trailing zero concentrations
`AUCIFO`	AUC infinity observed
`AUCIFOD`	AUCIFO / Dose
`AUCIFP`	AUC infinity predicted using CLSTP instead of CLST
`AUCIFPD`	AUCIFP / Dose
`AUCPEO`	AUC % extrapolation observed
`AUCPEP`	AUC % extrapolated for AUCIFP
`AUCPBEO`	AUC % back extrapolation observed, for bolus IV administration only
`AUCPBEP`	AUC % back extrapolation predicted with AUCIFP, for bolus IV administration only
`AUMCLST`	AUMC to the TLST
`AUMCIFO`	AUMC infinity observed using CLST
`AUMCIFP`	AUMC infinity determined by CLSTP
`AUMCPEO`	AUMC % extrapolated observed
`AUMCPEP`	AUMC % extrapolated predicted
`MRTIVLST`	mean residence time (MRT) to TLST, for intravascular administration
`MRTIVIFO`	mean residence time (MRT) infinity using CLST, for intravascular administration
`MRTIVIFP`	mean residence time (MRT) infinity using CLSTP, for intravascular administration
`MRTEVLST`	mean residence time (MRT) to TLST, for extravascular administration
`MRTEVIFO`	mean residence time (MRT) infinity using CLST, for extravascular administration
`MRTEVIFP`	mean residence time (MRT) infinity using CLSTP, for extravascular administration
`VZO`	volume of distribution determined by LAMZ and AUCIFO, for intravascular administration
`VZP`	volume of distribution determined by LAMZ and AUCIFP, for intravascular administration
`VZFO`	VZO for extravascular administration, VZO/F, F is bioavailability
`VZFP`	VZP for extravascular administration, VZP/F, F is bioavailability
`CLO`	clearance using AUCIFO, for intravascular administration
`CLP`	clearance using AUCIFP, for intravascular administration
`CLFO`	CLO for extravascular administration, CLO/F, F is bioavailability
`CLFP`	CLP for extravascular administration, CLP/F, F is bioavailability
`VSSO`	volume of distribution at steady state using CLST, for intravascular administration only
`VSSP`	volume of distribution at stead state using CLSTP, for intravascular administration only

Author(s)

Kyun-Seop Bae <[email protected]>

Examples

#rtfNCA(fileName="NCA-Theoph.rtf", Theoph, key="Subject", colTime="Time", 
#       colConc="conc", dose=320, doseUnit="mg", timeUnit="h", concUnit="mg/L")
#rtfNCA(fileName="NCA-Theoph.rtf", Theoph, key=c("Subject", "Wt"), colTime="Time",
#       colConc="conc", dose=320, doseUnit="mg", timeUnit="h", concUnit="mg/L")
#rtfNCA(fileName="NCA-Indometh.rtf", Indometh, key="Subject", colTime="time", 
#       colConc="conc", adm="Infusion", dur=0.5, dose=25, doseUnit="mg", 
#       timeUnit="h", concUnit="mg/L")
#rtfNCA(fileName="NCA-Theoph.rtf", Theoph, key="Subject", colTime="Time", 
#       colConc="conc", dose=320, doseUnit="mg", timeUnit="h", concUnit="mg/L")
#rtfNCA(fileName="NCA-Theoph.rtf", Theoph, key=c("Subject", "Wt"), colTime="Time",
#       colConc="conc", dose=320, doseUnit="mg", timeUnit="h", concUnit="mg/L")
#rtfNCA(fileName="NCA-Indometh.rtf", Indometh, key="Subject", colTime="time", 
#       colConc="conc", adm="Infusion", dur=0.5, dose=25, doseUnit="mg", 
#       timeUnit="h", concUnit="mg/L")

Text output of NCA for one subject

Description

This is the text form output.

Usage

txtNCA(x, y, dose = 0, adm = "Extravascular", dur = 0, doseUnit = "mg", 
       timeUnit = "h", concUnit = "ug/L", iAUC = "", down="Linear", R2ADJ=0, 
       MW = 0, SS = FALSE, excludeDelta = 1)
txtNCA(x, y, dose = 0, adm = "Extravascular", dur = 0, doseUnit = "mg", 
       timeUnit = "h", concUnit = "ug/L", iAUC = "", down="Linear", R2ADJ=0, 
       MW = 0, SS = FALSE, excludeDelta = 1)

Arguments

`x`	usually time
`y`	usually concentration
`dose`	given amount
`adm`	one of `"Bolus"` or `"Infusion"` or `"Extravascular"` to indicate drug administration mode
`dur`	duration of infusion
`doseUnit`	unit of dose
`timeUnit`	unit of time
`concUnit`	unit of concentration
`iAUC`	interval AUCs to calculate
`down`	either of `"Linear"` or `"Log"` to indicate the way to calculate AUC and AUMC
`R2ADJ`	Minimum adjusted R-square value to determine terminal slope automatically
`MW`	molecular weight of the drug
`SS`	if steady-state, this should be TRUE. AUCLST (AUClast) is used instead of AUCIFO (AUCinf) for the calculation of Vz (VZFO, VZO), CL (CLFO, CLO), and Vdss (VSSO).
`excludeDelta`	Improvement of R2ADJ larger than this value could exclude the last point. Default value 1 is for the compatibility with other software. Author recommends to use `excludeDelta` option with about 0.3.

Value

`CMAX`	maximum concentration, Cmax
`CMAXD`	dose normalized Cmax, CMAX / Dose, Cmax / Dose
`TMAX`	time of maximum concentration, Tmax
`TLAG`	time to observe the first non-zero concentration, for extravascular administration only
`CLST`	last positive concentration observed, Clast
`CLSTP`	last positive concentration predicted, Clast_pred
`TLST`	time of last positive concentration, Tlast
`LAMZHL`	half-life by lambda z, ln(2)/LAMZ
`LAMZ`	lambda_z negative of best fit terminal slope
`LAMZLL`	earliest time for LAMZ
`LAMZUL`	last time for LAMZ
`LAMZNPT`	number of points for LAMZ
`CORRXY`	correlation of log(concentration) and time
`R2`	R-squared
`R2ADJ`	R-squared adjusted
`C0`	back extrapolated concentration at time 0, for bolus intravascular administration only
`AUCLST`	AUC from 0 to TLST
`AUCALL`	AUC using all the given points, including trailing zero concentrations
`AUCIFO`	AUC infinity observed
`AUCIFOD`	AUCIFO / Dose
`AUCIFP`	AUC infinity predicted using CLSTP instead of CLST
`AUCIFPD`	AUCIFP / Dose
`AUCPEO`	AUC % extrapolation observed
`AUCPEP`	AUC % extrapolated for AUCIFP
`AUCPBEO`	AUC % back extrapolation observed, for bolus IV administration only
`AUCPBEP`	AUC % back extrapolation predicted with AUCIFP, for bolus IV administration only
`AUMCLST`	AUMC to the TLST
`AUMCIFO`	AUMC infinity observed using CLST
`AUMCIFP`	AUMC infinity determined by CLSTP
`AUMCPEO`	AUMC % extrapolated observed
`AUMCPEP`	AUMC % extrapolated predicted
`MRTIVLST`	mean residence time (MRT) to TLST, for intravascular administration
`MRTIVIFO`	mean residence time (MRT) infinity using CLST, for intravascular administration
`MRTIVIFP`	mean residence time (MRT) infinity using CLSTP, for intravascular administration
`MRTEVLST`	mean residence time (MRT) to TLST, for extravascular administration
`MRTEVIFO`	mean residence time (MRT) infinity using CLST, for extravascular administration
`MRTEVIFP`	mean residence time (MRT) infinity using CLSTP, for extravascular administration
`VZO`	volume of distribution determined by LAMZ and AUCIFO, for intravascular administration
`VZP`	volume of distribution determined by LAMZ and AUCIFP, for intravascular administration
`VZFO`	VZO for extravascular administration, VZO/F, F is bioavailability
`VZFP`	VZP for extravascular administration, VZP/F, F is bioavailability
`CLO`	clearance using AUCIFO, for intravascular administration
`CLP`	clearance using AUCIFP, for intravascular administration
`CLFO`	CLO for extravascular administration, CLO/F, F is bioavailability
`CLFP`	CLP for extravascular administration, CLP/F, F is bioavailability
`VSSO`	volume of distribution at steady state using CLST, for intravascular administration only
`VSSP`	volume of distribution at stead state using CLSTP, for intravascular administration only

Author(s)

Kyun-Seop Bae <[email protected]>

Examples

# For one subject
txtNCA(Theoph[Theoph$Subject=="1","Time"], Theoph[Theoph$Subject=="1","conc"], 
       dose=320, doseUnit="mg", concUnit="mg/L", timeUnit="h")

# or equivalently
x = Theoph[Theoph$Subject=="1","Time"]
y = Theoph[Theoph$Subject=="1","conc"]
txtNCA(x, y, dose=320, doseUnit="mg", concUnit="mg/L", timeUnit="h")

# For all subjects
IDs = sort(as.numeric(unique(Theoph[,"Subject"])))
nID = length(IDs)
Res = vector()
for (i in 1:nID) {
  tRes = txtNCA(Theoph[Theoph[,"Subject"]==IDs[i],"Time"], 
                Theoph[Theoph[,"Subject"]==IDs[i],"conc"], 
                dose=320, concUnit="mg/L")
  tRes = c(paste("ID =", IDs[i]), tRes, "")
  Res = c(Res, tRes)
}
Res
# For one subject
txtNCA(Theoph[Theoph$Subject=="1","Time"], Theoph[Theoph$Subject=="1","conc"], 
       dose=320, doseUnit="mg", concUnit="mg/L", timeUnit="h")

# or equivalently
x = Theoph[Theoph$Subject=="1","Time"]
y = Theoph[Theoph$Subject=="1","conc"]
txtNCA(x, y, dose=320, doseUnit="mg", concUnit="mg/L", timeUnit="h")

# For all subjects
IDs = sort(as.numeric(unique(Theoph[,"Subject"])))
nID = length(IDs)
Res = vector()
for (i in 1:nID) {
  tRes = txtNCA(Theoph[Theoph[,"Subject"]==IDs[i],"Time"], 
                Theoph[Theoph[,"Subject"]==IDs[i],"conc"], 
                dose=320, concUnit="mg/L")
  tRes = c(paste("ID =", IDs[i]), tRes, "")
  Res = c(Res, tRes)
}
Res

Package 'ncar'

Help Index

Noncompartmental Analysis for Pharmacokinetic Report

Description

Details

Author(s)

References

Examples

NCA output to pdf file

Description

Usage

Arguments

Value

Author(s)

See Also

Examples

Convert sNCA output table to text form

Description

Usage

Arguments

Value

Author(s)

See Also

Examples

Round Half Away from Zero

Description

Usage

Arguments

Details

Value

Author(s)

References

Examples

NCA Report Configuation Table

Description

Usage

Format

Details

NCA output to rtf file

Description

Usage

Arguments

Value

Author(s)

See Also

Examples

Text output of NCA for one subject

Description

Usage

Arguments

Value

Author(s)

See Also

Examples