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message: 'To cite package "futility" in publications use:'
type: software
license: GPL-2.0-only
title: 'futility: Interim Analysis of Operational Futility in Randomized Trials with
  Time-to-Event Endpoints and Fixed Follow-Up'
version: '0.4'
abstract: Randomized clinical trials commonly follow participants for a time-to-event
  efficacy endpoint for a fixed period of time. Consequently, at the time when the
  last enrolled participant completes their follow-up, the number of observed endpoints
  is a random variable. Assuming data collected through an interim timepoint, simulation-based
  estimation and inferential procedures in the standard right-censored failure time
  analysis framework are conducted for the distribution of the number of endpoints--in
  total as well as by treatment arm--at the end of the follow-up period. The future
  (i.e., yet unobserved) enrollment, endpoint, and dropout times are generated according
  to mechanisms specified in the simTrial() function in the 'seqDesign' package. A
  Bayesian model for the endpoint rate, offering the option to specify a robust mixture
  prior distribution, is used for generating future data (see the vignette for details).
  Inference can be restricted to participants who received treatment according to
  the protocol and are observed to be at risk for the endpoint at a specified timepoint.
  Plotting functions are provided for graphical display of results.
authors:
- family-names: Zhuang
  given-names: Yingying
  email: yyzhuang@uw.edu
- family-names: Juraska
  given-names: Michal
  email: mjuraska@fredhutch.org
repository: https://CRAN.R-project.org/package=futility
repository-code: https://github.com/mjuraska/futility
url: https://github.com/mjuraska/futility
date-released: '2019-04-10'
contact:
- family-names: Juraska
  given-names: Michal
  email: mjuraska@fredhutch.org