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cff-version: 1.2.0
message: 'To cite package "fragility" in publications use:'
type: software
license: GPL-2.0-or-later
title: 'fragility: Assessing and Visualizing Fragility of Clinical Results with Binary
  Outcomes'
version: '1.6'
doi: 10.32614/CRAN.package.fragility
abstract: 'A collection of user-friendly functions for assessing and visualizing fragility
  of individual studies (Walsh et al., 2014 <https://doi.org/10.1016/j.jclinepi.2013.10.019>;
  Lin, 2021 <https://doi.org/10.1111/jep.13428>), conventional pairwise meta-analyses
  (Atal et al., 2019 <https://doi.org/10.1016/j.jclinepi.2019.03.012>), and network
  meta-analyses of multiple treatments with binary outcomes (Xing et al., 2020 <https://doi.org/10.1016/j.jclinepi.2020.07.003>).
  The included functions are designed to: 1) calculate the fragility index (i.e.,
  the minimal event status modifications that can alter the significance or non-significance
  of the original result) and fragility quotient (i.e., fragility index divided by
  sample size) at a specific significance level; 2) give the cases of event status
  modifications for altering the result''s significance or non-significance and visualize
  these cases; 3) visualize the trend of statistical significance as event status
  is modified; 4) efficiently derive fragility indexes and fragility quotients at
  multiple significance levels, and visualize the relationship between these fragility
  measures against the significance levels; and 5) calculate fragility indexes and
  fragility quotients of multiple datasets (e.g., a collection of clinical trials
  or meta-analyses) and produce plots of their overall distributions. The outputs
  from these functions may inform the robustness of clinical results in terms of statistical
  significance and aid the interpretation of fragility measures. The usage of this
  package is illustrated in Lin et al. (2023 <https://doi.org/10.1016/j.ajog.2022.08.053>)
  and detailed in Lin and Chu (2022 <https://doi.org/10.1371/journal.pone.0268754>).'
authors:
- family-names: Lin
  given-names: Lifeng
  email: lifenglin@arizona.edu
  orcid: https://orcid.org/0000-0002-3562-9816
- family-names: Chu
  given-names: Haitao
  email: chux0051@umn.edu
  orcid: https://orcid.org/0000-0003-0932-598X
repository: https://CRAN.R-project.org/package=fragility
date-released: '2024-11-21'
contact:
- family-names: Lin
  given-names: Lifeng
  email: lifenglin@arizona.edu
  orcid: https://orcid.org/0000-0002-3562-9816