# --------------------------------------------
# CITATION file created with {cffr} R package
# See also: https://docs.ropensci.org/cffr/
# --------------------------------------------
 
cff-version: 1.2.0
message: 'To cite package "escalation" in publications use:'
type: software
license: GPL-3.0-or-later
title: 'escalation: A Modular Approach to Dose-Finding Clinical Trials'
version: 0.1.10
doi: 10.32614/CRAN.package.escalation
abstract: Methods for working with dose-finding clinical trials. We provide implementations
  of many dose-finding clinical trial designs, including the continual reassessment
  method (CRM) by O'Quigley et al. (1990) <https://doi.org/10.2307/2531628>, the toxicity
  probability interval (TPI) design by Ji et al. (2007) <https://doi.org/10.1177/1740774507079442>,
  the modified TPI (mTPI) design by Ji et al. (2010) <https://doi.org/10.1177/1740774510382799>,
  the Bayesian optimal interval design (BOIN) by Liu & Yuan (2015) <https://doi.org/10.1111/rssc.12089>,
  EffTox by Thall & Cook (2004) <https://doi.org/10.1111/j.0006-341X.2004.00218.x>;
  the design of Wages & Tait (2015) <https://doi.org/10.1080/10543406.2014.920873>,
  and the 3+3 described by Korn et al. (1994) <https://doi.org/10.1002/sim.4780131802>.
  All designs are implemented with a common interface. We also offer optional additional
  classes to tailor the behaviour of all designs, including avoiding skipping doses,
  stopping after n patients have been treated at the recommended dose, stopping when
  a toxicity condition is met, or demanding that n patients are treated before stopping
  is allowed. By daisy-chaining together these classes using the pipe operator from
  'magrittr', it is simple to tailor the behaviour of a dose-finding design so it
  behaves how the trialist wants. Having provided a flexible interface for specifying
  designs, we then provide functions to run simulations and calculate dose-paths for
  future cohorts of patients.
authors:
- family-names: Brock
  given-names: Kristian
  email: kristian.brock@gmail.com
  orcid: https://orcid.org/0000-0002-3921-0166
- family-names: Slade
  given-names: Daniel
  orcid: https://orcid.org/0000-0001-6063-1283
- family-names: Sweeting
  given-names: Michael
  orcid: https://orcid.org/0000-0003-0980-8965
repository: https://CRAN.R-project.org/package=escalation
repository-code: https://github.com/brockk/escalation
url: https://brockk.github.io/escalation/
date-released: '2024-06-26'
contact:
- family-names: Brock
  given-names: Kristian
  email: kristian.brock@gmail.com
  orcid: https://orcid.org/0000-0002-3921-0166