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cff-version: 1.2.0
message: 'To cite package "cobenrich" in publications use:'
type: software
license: GPL-3.0-only
title: 'cobenrich: Using Multiple Continuous Biomarkers for Patient Enrichment in
  Two-Stage Clinical Designs'
version: 1.0.1
doi: 10.32614/CRAN.package.cobenrich
abstract: Enrichment strategies play a critical role in modern clinical trial design,
  especially as precision medicine advances the focus on patient-specific efficacy.
  Recent developments in enrichment design have introduced biomarker randomness and
  accounted for the correlation structure between treatment effect and biomarker,
  resulting in a two-stage threshold enrichment design. We propose novel two-stage
  enrichment designs capable of handling two or more continuous biomarkers. See Zhang,
  F. and Gou, J. (2025). Using multiple biomarkers for patient enrichment in two-stage
  clinical designs. Technical Report.
authors:
- family-names: Gou
  given-names: Jiangtao
  email: gouRpackage@gmail.com
- family-names: Zhang
  given-names: Fengqing (Zoe)
repository: https://cran.r-universe.dev
commit: 3f8155d2e6c081489c4347cd0c9dbb80510eeeb1
date-released: '2025-04-15'
contact:
- family-names: Gou
  given-names: Jiangtao
  email: gouRpackage@gmail.com