Package: cobenrich
Type: Package
Title: Using Multiple Continuous Biomarkers for Patient Enrichment in
        Two-Stage Clinical Designs
Version: 1.0.1
Authors@R: c(
    person("Jiangtao", "Gou", email = "gouRpackage@gmail.com", role = c("aut", "cre")),
    person("Fengqing (Zoe)", "Zhang", role = "aut"))
Description: Enrichment strategies play a critical role in modern
        clinical trial design, especially as precision medicine
        advances the focus on patient-specific efficacy. Recent
        developments in enrichment design have introduced biomarker
        randomness and accounted for the correlation structure between
        treatment effect and biomarker, resulting in a two-stage
        threshold enrichment design. We propose novel two-stage
        enrichment designs capable of handling two or more continuous
        biomarkers. See Zhang, F. and Gou, J. (2025). Using multiple
        biomarkers for patient enrichment in two-stage clinical
        designs. Technical Report.
License: GPL-3
Encoding: UTF-8
Depends: R (>= 4.2.0)
Imports: tmvtnorm (>= 1.2), stats (>= 4.0.0)
RoxygenNote: 7.3.2
NeedsCompilation: no
Packaged: 2026-09-24 07:38:55 UTC; root
Author: Jiangtao Gou [aut, cre], Fengqing (Zoe) Zhang [aut]
Maintainer: Jiangtao Gou <gouRpackage@gmail.com>
Repository: https://cran.r-universe.dev
Date/Publication: 2025-04-15 19:30:12 UTC
RemoteUrl: https://github.com/cran/cobenrich
RemoteRef: HEAD
RemoteSha: 3f8155d2e6c081489c4347cd0c9dbb80510eeeb1