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# CITATION file created with {cffr} R package
# See also: https://docs.ropensci.org/cffr/
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cff-version: 1.2.0
message: 'To cite package "cit" in publications use:'
type: software
license: Artistic-2.0
title: 'cit: Causal Inference Test'
version: 2.3.2
doi: 10.1093/bioinformatics/btw135
identifiers:
- type: doi
  value: 10.32614/CRAN.package.cit
abstract: A likelihood-based hypothesis testing approach is implemented for assessing
  causal mediation. Described in Millstein, Chen, and Breton (2016), <DOI:10.1093/bioinformatics/btw135>,
  it could be used to test for mediation of a known causal association between a DNA
  variant, the 'instrumental variable', and a clinical outcome or phenotype by gene
  expression or DNA methylation, the potential mediator. Another example would be
  testing mediation of the effect of a drug on a clinical outcome by the molecular
  target. The hypothesis test generates a p-value or permutation-based FDR value with
  confidence intervals to quantify uncertainty in the causal inference. The outcome
  can be represented by either a continuous or binary variable, the potential mediator
  is continuous, and the instrumental variable can be continuous or binary and is
  not limited to a single variable but may be a design matrix representing multiple
  variables.
authors:
- family-names: Millstein
  given-names: Joshua
  email: joshua.millstein@usc.edu
  orcid: https://orcid.org/0000-0001-7961-8943
preferred-citation:
  type: article
  title: 'cit: hypothesis testing software for mediation analysis in genomic applications'
  authors:
  - family-names: Millstein
    given-names: Joshua
    email: joshua.millstein@usc.edu
    orcid: https://orcid.org/0000-0001-7961-8943
  - family-names: Chen
    given-names: Gary
  - family-names: Breton
    given-names: Carrie
  journal: Bioinformatics
  year: '2016'
  month: '8'
  volume: '32'
  issue: '15'
  doi: 10.1093/bioinformatics/btw135
  url: https://doi.org/10.1093/bioinformatics/btw135
  issn: 1367-4803
repository: https://CRAN.R-project.org/package=cit
repository-code: https://github.com/USCbiostats/cit
url: https://github.com/USCbiostats/cit
date-released: '2024-06-27'
contact:
- family-names: Millstein
  given-names: Joshua
  email: joshua.millstein@usc.edu
  orcid: https://orcid.org/0000-0001-7961-8943
references:
- type: manual
  title: 'cit: Causal Inference Test'
  authors:
  - family-names: Millstein
    given-names: Joshua
    email: joshua.millstein@usc.edu
    orcid: https://orcid.org/0000-0001-7961-8943
  year: '2024'
  notes: R package version 2.3.2
  publisher:
    name: CRAN
  url: https://cran.r-project.org/package=cit