Package: cit
Type: Package
Title: Causal Inference Test
Version: 2.3.2
Date: 2024-06-27
Authors@R: person("Joshua", "Millstein", email = "joshua.millstein@usc.edu", role =
	c("aut", "cre"), comment = c(ORCID="0000-0001-7961-8943"))
Description: A likelihood-based hypothesis testing approach is
        implemented for assessing causal mediation. Described in
        Millstein, Chen, and Breton (2016),
        <DOI:10.1093/bioinformatics/btw135>, it could be used to test
        for mediation of a known causal association between a DNA
        variant, the 'instrumental variable', and a clinical outcome or
        phenotype by gene expression or DNA methylation, the potential
        mediator. Another example would be testing mediation of the
        effect of a drug on a clinical outcome by the molecular target.
        The hypothesis test generates a p-value or permutation-based
        FDR value with confidence intervals to quantify uncertainty in
        the causal inference. The outcome can be represented by either
        a continuous or binary variable, the potential mediator is
        continuous, and the instrumental variable can be continuous or
        binary and is not limited to a single variable but may be a
        design matrix representing multiple variables.
SystemRequirements: gsl (with development libraries libgsl-dev)
License: Artistic-2.0
LazyLoad: yes
Suggests: tinytest
Depends: R (>= 4.3.0)
BugReports: https://github.com/USCbiostats/cit/issues
URL: https://github.com/USCbiostats/cit
NeedsCompilation: yes
Packaged: 2026-10-24 07:08:09 UTC; root
Author: Joshua Millstein [aut, cre]
        (<https://orcid.org/0000-0001-7961-8943>)
Maintainer: Joshua Millstein <joshua.millstein@usc.edu>
RoxygenNote: 7.3.1
Config/pak/sysreqs: libgsl0-dev
Repository: https://cran.r-universe.dev
Date/Publication: 2024-06-29 02:41:58 UTC
RemoteUrl: https://github.com/cran/cit
RemoteRef: HEAD
RemoteSha: cf288c84f9c4c018339faea6859ccb2833af291a