Package: cepip Type: Package Title: Cell Explanatory Power with Inflection Point (CEP-IP) with CMRF Version: 0.1.0 Authors@R: person("Kah Keng", "Wong", role = c("aut", "cre"), email = "kahkeng3@gmail.com", comment = c(ORCID = "0000-0001-7359-6202")) Description: Implements the cell explanatory power with inflection point (CEP-IP) framework for single-cell co-expression analysis. A generalized additive model (GAM) fitted by restricted maximum likelihood (REML) with a penalized residual sum of squares (PRSS) search over the basis dimension relates a gene of interest to the mean of its partner genes. Cells are ranked by their explanatory power, and the inflection point is the first negative-to-positive zero crossing of a residual GAM. Optional extensions are the Spearman-Kendall cell-level score (SKCS) and the copula monotone recovery filter (CMRF), which recovers cells near the module through a tolerance band and a repeated stratified k-fold cross-validation gate. Downstream helpers give per-donor module fractions, paired donor-level differential expression and donor-level association models. CEP-IP is described in Wong (2026) . License: MIT + file LICENSE Encoding: UTF-8 LazyData: true Depends: R (>= 4.1.0) Imports: mgcv, stats, utils, methods, grDevices, grid, parallel, Matrix, ggplot2 (>= 3.4.0), gridExtra, openxlsx Suggests: Hmisc, energy, clinfun, pcaPP, testthat (>= 3.0.0), knitr, rmarkdown VignetteBuilder: knitr Config/testthat/edition: 3 RoxygenNote: 7.3.1 URL: https://github.com/kahkengwong/cepip BugReports: https://github.com/kahkengwong/cepip/issues NeedsCompilation: no Packaged: 2026-10-29 22:01:47 UTC; root Author: Kah Keng Wong [aut, cre] (ORCID: ) Maintainer: Kah Keng Wong Repository: https://cran.r-universe.dev Date/Publication: 2026-10-29 21:14:50 UTC RemoteUrl: https://github.com/cran/cepip RemoteRef: HEAD RemoteSha: 49283c8c1341a9b015bfe35820d2b1f69fa87f03