Package: ballast
Title: Stress-Test a Pre-Specified Mixed Model for Repeated Measures
Version: 0.6.1
Authors@R: c(
    person("Adam", "Sullivan", email = "asullivan@capricor.com",
           role = c("aut", "cre", "cph"),
           comment = c(ORCID = "0000-0002-9429-3611")),
    person("Nathan", "Hogan", role = "ctb",
           comment = "validation of the SAS reference results"),
    person("Capricor Therapeutics", role = "fnd"))
Description: Refits one pre-specified mixed model for repeated measures
        (MMRM) under families of data and analytic perturbations
        (covariance structure, degrees-of-freedom method and variance
        estimator, covariate set, analysis population, alternative
        analysis data sets, leave-one-out deletions, crossed
        specification grids, re-randomisation tests, delta-adjusted and
        reference-based multiple imputation, and alternative
        estimators) and judges every refit against the pre-specified
        estimate, confidence interval and p-value. Classifies the
        result as robust, sensitive or fragile, with a separate flag
        for marginal significance, and estimates by simulation the
        probability that a planned design gives a significant and
        robust result. Fitting uses 'mmrm' (Sabanes Bove et al., 2024,
        <https://openpharma.github.io/mmrm/>) with 'SAS' 'PROC MIXED'
        conventions for the least-squares-mean contrast, Kenward-Roger
        adjustment and the corrected Akaike criterion. Reference-based
        multiple imputation follows Carpenter, Roger and Kenward (2013)
        <doi:10.1080/10543406.2013.834911> and was checked against
        'rbmi' (Gower-Page, Noci and Wolbers, 2022)
        <doi:10.21105/joss.04251>.
License: MIT + file LICENSE
Encoding: UTF-8
Language: en-GB
Depends: R (>= 4.1.0)
Imports: mmrm (>= 0.3.0), stats, utils, parallel
Suggests: ggplot2, emmeans, nlme, MASS, flextable, officer, plotly,
        htmlwidgets, htmltools, jsonlite, testthat (>= 3.0.0), knitr,
        rmarkdown
Config/testthat/edition: 3
VignetteBuilder: knitr
URL: https://github.com/Sullivanstatistics/ballast
BugReports: https://github.com/Sullivanstatistics/ballast/issues
Config/roxygen2/version: 8.0.0
NeedsCompilation: no
Packaged: 2026-10-30 21:10:31 UTC; root
Author: Adam Sullivan [aut, cre, cph] (ORCID:
        <https://orcid.org/0000-0002-9429-3611>), Nathan Hogan [ctb]
        (validation of the SAS reference results), Capricor
        Therapeutics [fnd]
Maintainer: Adam Sullivan <asullivan@capricor.com>
Repository: https://cran.r-universe.dev
Date/Publication: 2026-10-30 19:32:47 UTC
RemoteUrl: https://github.com/cran/ballast
RemoteRef: HEAD
RemoteSha: 44a60e9aa243e70c5fc1f03267b7f54d3eacb7a4