{ "_id": "6a227647cd65a98ecbd4ae60", "Package": "wnl", "Version": "0.8.5", "Title": "Minimization Tool for Pharmacokinetic-Pharmacodynamic Data\nAnalysis", "Description": "This is a set of minimization tools (maximum likelihood\nestimation and least square fitting) to solve examples in the\nJohan Gabrielsson and Dan Weiner's book \"Pharmacokinetic and\nPharmacodynamic Data Analysis - Concepts and Applications\" 5th\ned. (ISBN:9198299107). Examples include linear and nonlinear\ncompartmental model, turn-over model, single or multiple dosing\nbolus/infusion/oral models, allometry, toxicokinetics,\nreversible metabolism, in-vitro/in-vivo extrapolation,\nenterohepatic circulation, metabolite modeling, Emax model,\ninhibitory model, tolerance model, oscillating response model,\nenantiomer interaction model, effect compartment model,\ndrug-drug interaction model, receptor occupancy model, and\nrebound phenomena model.", "Authors@R": "person(given=\"Kyun-Seop\", family=\"Bae\", role=c(\"aut\", \"cre\", \"cph\"), email=\"k@acr.kr\")", "Author": "Kyun-Seop Bae [aut, cre, cph]", "Maintainer": "Kyun-Seop Bae ", "Copyright": "2017-, Kyun-Seop Bae", "License": "GPL-3", "NeedsCompilation": "no", "LazyLoad": "yes", "URL": "https://cran.r-project.org/package=wnl", "Packaged": { "Date": "2026-06-05 07:07:42 UTC", "User": "root" }, "Repository": "https://cran.r-universe.dev", "Date/Publication": "2026-03-07 16:46:42 UTC", "RemoteUrl": "https://github.com/cran/wnl", "RemoteRef": "HEAD", "RemoteSha": "3abddf1d87525f6b249cd27d1ce80d27008f60c3", "MD5sum": "1cc274a351e900f5163f81a41dcd648c", "_user": "cran", "_type": "src", "_file": "wnl_0.8.5.tar.gz", "_fileid": "29f3916f5be89e6c7f358b7ccb38cd06fd21896760cdc9bf160de93877a977f2", "_filesize": 243934, "_sha256": "29f3916f5be89e6c7f358b7ccb38cd06fd21896760cdc9bf160de93877a977f2", "_created": "2026-06-05T07:07:42.000Z", "_published": "2026-06-05T07:09:59.371Z", "_distro": "noble", "_jobs": [ { "job": 79680776683, "time": 97, "config": "linux-devel-x86_64", "r": "4.7.0", "check": "OK", "artifact": "7430818056" }, { "job": 79680776726, "time": 91, "config": "linux-release-x86_64", "r": "4.6.0", "check": "OK", "artifact": "7430815973" }, { "job": 79680459638, "time": 150, "config": "source", "r": "4.6.0", "check": "OK", "artifact": "7430792341" }, { "job": 79680776673, "time": 101, "config": "wasm-release", "r": "4.6.0", "check": "OK", "artifact": "7430818340" } ], "_buildurl": "https://github.com/r-universe/cran/actions/runs/27000749260", "_status": "success", "_host": "GitHub-Actions", "_upstream": "https://github.com/cran/wnl", "_commit": { "id": "3abddf1d87525f6b249cd27d1ce80d27008f60c3", "author": "Kyun-Seop Bae ", "committer": "cran-robot ", "message": "version 0.8.5\n", "time": 1772902002 }, "_maintainer": { "name": "Kyun-Seop Bae", "email": "k@acr.kr" }, "_registered": true, "_dependencies": [ { "package": "R", "version": ">= 3.5.0", "role": "Depends" }, { "package": "numDeriv", "role": "Depends" } ], "_owner": "cran", "_selfowned": false, "_usedby": 0, "_updates": [ { "week": "2025-36", "n": 1 }, { "week": "2026-10", "n": 1 } ], "_tags": [ { "name": "0.8.4", "date": "2025-09-07" }, { "name": "0.8.5", "date": "2026-03-07" } ], "_stars": 1, "_userbio": { "uuid": 6899542, "type": "organization", "name": "cran", "description": "Unofficial read-only mirror of all CRAN R packages" }, "_downloads": { "count": 607, "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/wnl" }, "_searchresults": 8, "_rbuild": "4.6.0", "_assets": [ "extra/citation.cff", "extra/citation.html", "extra/citation.json", "extra/citation.txt", "extra/contents.json", "extra/NEWS.html", "extra/NEWS.txt", "extra/wnl.html", "manual.pdf" ], "_realowner": "cran", "_cranurl": false, "_releases": [ { "version": "0.3.1", "date": "2017-10-16" }, { "version": "0.3.2", "date": "2017-12-01" }, { "version": "0.3.3", "date": "2018-03-02" }, { "version": "0.4.0", "date": "2018-04-02" }, { "version": "0.4.1", "date": "2018-06-14" }, { "version": "0.5.0", "date": "2019-05-10" }, { "version": "0.5.1", "date": "2019-07-10" }, { "version": "0.6.0", "date": "2020-07-16" }, { "version": "0.6.1", "date": "2020-08-27" }, { "version": "0.6.2", "date": "2021-08-07" }, { "version": "0.6.3", "date": "2021-09-06" }, { "version": "0.6.4", "date": "2021-11-22" }, { "version": "0.7.0", "date": "2022-10-28" }, { "version": "0.7.1", "date": "2022-11-30" }, { "version": "0.7.2", "date": "2023-03-26" }, { "version": "0.7.3", "date": "2023-04-25" }, { "version": "0.8.0", "date": "2024-02-22" }, { "version": "0.8.1", "date": "2024-06-01" }, { "version": "0.8.2", "date": "2025-02-21" }, { "version": "0.8.3", "date": "2025-03-23" }, { "version": "0.8.4", "date": "2025-09-07" }, { "version": "0.8.5", "date": "2026-03-07" } ], "_exports": [ "cmpChi", "Comp1", "DAT", "dx", "e", "EnvObj", "ExpandDH", "g2inv", "Hougaard", "hSkew", "nComp", "nGradient", "nHessian", "nlr", "ObjDef", "ObjEst", "ObjLS", "pComp", "pProf", "prun", "run.test", "s2o", "Secondary", "SolComp2", "SolComp3", "wnl5" ], "_help": [ { "page": "wnl-package", "title": "Minimization Tool for Pharmacokinetic-Pharmacodynamic Data Analysis", "topics": [ "wnl-package", "wnl" ] }, { "page": "cmpChi", "title": "Compare model with Chi-square test", "topics": [ "cmpChi" ] }, { "page": "Comp1", "title": "One compartment model - 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