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  "Title": "Win Time Methods for Time-to-Event Data in Clinical Trials",
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  "Authors@R": "c(person(\"James\", \"Troendle\", email = \"james.troendle@nih.gov\", role = c(\"aut\", \"cre\")),\nperson(\"Samuel\", \"Lawrence\", email = \"roaders79@gmail.com\", role = \"aut\"))",
  "Description": "Performs an analysis of time-to-event clinical trial data\nusing various \"win time\" methods, including 'ewt', 'ewtr',\n'rmt', 'ewtp', 'rewtp', 'ewtpr', 'rewtpr', 'max', 'wtr',\n'rwtr', 'pwt', and 'rpwt'. These methods are used to calculate\nand compare treatment effects on ordered composite endpoints.\nThe package handles event times, event indicators, and\ntreatment arm indicators and supports calculations on observed\nand resampled data. Detailed explanations of each method and\nusage examples are provided in \"Use of win time for ordered\ncomposite endpoints in clinical trials,\" by Troendle et al.\n(2024)<https://pubmed.ncbi.nlm.nih.gov/38417455/>. For more\ninformation, see the package documentation or the vignette\ntitled \"Introduction to wintime.\"",
  "URL": "https://pubmed.ncbi.nlm.nih.gov/38417455/",
  "License": "MIT + file LICENSE",
  "Encoding": "UTF-8",
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  "NeedsCompilation": "no",
  "Packaged": {
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    "User": "root"
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  "Author": "James Troendle [aut, cre], Samuel Lawrence [aut]",
  "Maintainer": "James Troendle <james.troendle@nih.gov>",
  "Repository": "https://cran.r-universe.dev",
  "Date/Publication": "2026-04-23 17:52:38 UTC",
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    "message": "version 0.4.4\n",
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    "email": "james.troendle@nih.gov"
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    "description": "Unofficial read-only mirror of all CRAN R packages"
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  "_assets": [
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    "manual.pdf"
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  "_cranurl": false,
  "_releases": [
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      "date": "2024-09-02"
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  "_exports": [
    "COMP",
    "km",
    "markov",
    "wintime"
  ],
  "_help": [
    {
      "page": "bootstrap",
      "title": "Resample using bootstraps",
      "topics": [
        "bootstrap"
      ]
    },
    {
      "page": "COMP",
      "title": "Run composite analysis",
      "topics": [
        "COMP"
      ]
    },
    {
      "page": "EWT",
      "title": "Expected win time",
      "topics": [
        "EWT"
      ]
    },
    {
      "page": "EWTP",
      "title": "Expected win time against trial population",
      "topics": [
        "EWTP"
      ]
    },
    {
      "page": "EWTPR",
      "title": "Expected win time against trial population With redistribution to the right",
      "topics": [
        "EWTPR"
      ]
    },
    {
      "page": "EWTR",
      "title": "Expected win time against reference",
      "topics": [
        "EWTR"
      ]
    },
    {
      "page": "getWintimeIntegral",
      "title": "Helper functions for package functions",
      "topics": [
        "getWintimeIntegral"
      ]
    },
    {
      "page": "getWintimeIntegral_rest",
      "title": "Win time difference with time restriction",
      "topics": [
        "getWintimeIntegral_rest"
      ]
    },
    {
      "page": "km",
      "title": "Fit a Kaplan-Meier model",
      "topics": [
        "km"
      ]
    },
    {
      "page": "markov",
      "title": "Fit a Markov model",
      "topics": [
        "markov"
      ]
    },
    {
      "page": "perm",
      "title": "Resample using permutations",
      "topics": [
        "perm"
      ]
    },
    {
      "page": "PWT",
      "title": "Pairwise win time",
      "topics": [
        "PWT"
      ]
    },
    {
      "page": "REWTP",
      "title": "Expected win time against trial population",
      "topics": [
        "REWTP"
      ]
    },
    {
      "page": "REWTPR",
      "title": "Time Restricted Expected win time against trial population With redistribution to the right",
      "topics": [
        "REWTPR"
      ]
    },
    {
      "page": "RMT",
      "title": "Restricted mean survival in favor of treatment",
      "topics": [
        "RMT"
      ]
    },
    {
      "page": "RPWT",
      "title": "Time Restricted Pairwise win time",
      "topics": [
        "RPWT"
      ]
    },
    {
      "page": "RWTR",
      "title": "Restricted win time ratio",
      "topics": [
        "RWTR"
      ]
    },
    {
      "page": "setEventTimes",
      "title": "Created a sorted vector of event times",
      "topics": [
        "setEventTimes"
      ]
    },
    {
      "page": "setKM",
      "title": "Set event times and indicators used in the Kaplan-Meier survival curve calculation",
      "topics": [
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      ]
    },
    {
      "page": "wintime",
      "title": "Run a win time calculation",
      "topics": [
        "wintime"
      ]
    },
    {
      "page": "WTR",
      "title": "Win time ratio",
      "topics": [
        "WTR"
      ]
    }
  ],
  "_rundeps": [
    "lattice",
    "Matrix",
    "survival"
  ],
  "_vignettes": [
    {
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      "filename": "wintime_vignette.html",
      "title": "wintime_vignette",
      "engine": "knitr::rmarkdown",
      "headings": [
        "wintime Package Guide",
        "Installation",
        "Load Required Packages",
        "Example Data",
        "wintime Function",
        "Win time ratio (wtr)",
        "Restricted win time ratio (rwtr)",
        "Pairwise win time (pwt)",
        "Expected win time against reference (ewtr)",
        "Expected win time (ewt)",
        "EWTR-composite max test (max)",
        "Restricted mean survival in favor of treatment (rmt)",
        "Resampling",
        "ewt with 10 Resamples",
        "wtr with 5 Resamples",
        "Resampleing Cont.",
        "Survival Models",
        "Model Functions",
        "Parameters",
        "markov Function",
        "km Function"
      ],
      "created": "2024-09-03 02:52:42",
      "modified": "2025-06-30 19:29:55",
      "commits": 2
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