{ "_id": "6a2137d7cd65a98ecbd270ec", "Type": "Package", "Package": "refineR", "Version": "2.0.0", "Date": "2025-11-05", "Encoding": "UTF-8", "Title": "Reference Interval Estimation using Real-World Data", "Author": "Matthias Beck [aut, cre] (ORCID:\n), Tatjana Ammer [aut]\n(ORCID: ), Christopher M\nRank [aut], Andre Schuetzenmeister [aut] (ORCID:\n)", "Maintainer": "Matthias Beck ", "Authors@R": "c(\nperson(given =\"Matthias\", family = \"Beck\", email =\"matthias.beck.mb1@roche.com\", role =c(\"aut\", \"cre\"), comment = c(ORCID = \"0009-0008-7678-4581\")),\nperson(given =\"Tatjana\", family =\"Ammer\", email =\"tatjana.ammer@roche.com\", role =\"aut\", comment = c(ORCID = \"0000-0003-2809-0266\")),\nperson(given =\"Christopher M\", family = \"Rank\", email =\"christopher.rank@roche.com\", role =\"aut\", comment = c(ORCID = \"\")),\nperson(given =\"Andre\", family =\"Schuetzenmeister\", email =\"andre.schuetzenmeister@roche.com\", role =\"aut\", comment = c(ORCID = \"0000-0002-2964-5502\")))", "Description": "Indirect method for the estimation of reference intervals\n(RIs) using Real-World Data ('RWD') and methods for comparing\nand verifying RIs. Estimates RIs by applying advanced\nstatistical methods to routine diagnostic test measurements,\nwhich include both pathological and non-pathological samples,\nto model the distribution of non-pathological samples. This\ndistribution is then used to derive reference intervals and\nsupport RI verification, i.e., deciding if a specific RI is\nsuitable for the local population. The package also provides\nfunctions for printing and plotting algorithm results. See\n?refineR for a detailed description of features. Version 1.0 of\nthe algorithm is described in 'Ammer et al. (2021)'\n. Additional guidance is in\n'Ammer et al. (2023)' . The\nverification method is described in 'Beck et al. 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"calculateCostHist", "title": "Calculate costs for a specific combinations of lambda, muVec and sigmaVec.", "topics": [ "calculateCostHist" ] }, { "page": "cdfTruncatedBoxCox", "title": "Function to calculate the RI from a set of parameters", "topics": [ "cdfTruncatedBoxCox" ] }, { "page": "checkInvalidArgs", "title": "Check Invalid Arguments", "topics": [ "checkInvalidArgs" ] }, { "page": "createVerificationTab", "title": "Create Verification Table", "topics": [ "createVerificationTab" ] }, { "page": "defineSearchRegions", "title": "Helper function to define search regions for mu and sigma and to get the region around the main peak 'ab'", "topics": [ "defineSearchRegions" ] }, { "page": "estimateAB", "title": "Helper function to find region around the main peak of a distribution", "topics": [ "estimateAB" ] }, { "page": "findMainPeak", "title": "Helper function to find the main peak of a distribution", "topics": [ "findMainPeak" ] }, { "page": "findPeaksAndValleys", "title": "Find the 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"title": "Calculate similarity of two reference intervals", "topics": [ "getRISimilarity" ] }, { "page": "getSumForPArea", "title": "Helper function to calculate the amount of observed and estimated data points within specified regions around the peak.", "topics": [ "getSumForPArea" ] }, { "page": "getVerificationArgs", "title": "Get the correct values for RI, RIperc, Lambda, and Shift for the verification", "topics": [ "getVerificationArgs" ] }, { "page": "invBoxCox", "title": "Inverse of the one-parameter Box-Cox transformation.", "topics": [ "invBoxCox" ] }, { "page": "optimizeGrid", "title": "Helper function for grid search for mu and sigma.", "topics": [ "optimizeGrid" ] }, { "page": "perc_ci_asymptotic", "title": "Function to approximate the sampling uncertainty of quantiles using the asymptotic method", "topics": [ "perc_ci_asymptotic" ] }, { "page": "plot.RWDRI", "title": "Standard plot method for objects of class 'RWDRI'", "topics": [ "plot.RWDRI" ] }, { "page": 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