{
  "_id": "6a1e7d821d7bb097a0a65840",
  "Package": "randomizeR",
  "Type": "Package",
  "Title": "Randomization for Clinical Trials",
  "Version": "3.0.2",
  "Authors@R": "c(person(given = \"David\",\nfamily = \"Schindler\",\nrole = \"aut\",\nemail = \"dv.schindler@gmail.com\"),\nperson(given = \"Diane\",\nfamily = \"Uschner\",\nrole = \"aut\",\nemail = \"Diane.Uschner@gmail.com\"),\nperson(given = \"Denis\",\nfamily = \"Razsolkov\",\nrole = \"ctb\",\nemail = \"denis.razsolkov@rwth-aachen.de\"),\nperson(given = \"Dimitar\",\nfamily = \"Mihaylov\",\nrole = \"ctb\",\nemail = \"dimitar.mihaylov@rwth-aachen.de\"),\nperson(given = \"Marcia Viviane\",\nfamily = \"Rueckbeil\",\nrole = \"ctb\",\nemail = \"marcia.rueckbeil@rwth-aachen.de\"),\nperson(given = \"Martin\",\nfamily = \"Manolov\",\nrole = \"ctb\",\nemail = \"martin.manolov@rwth-aachen.de\"),\nperson(given = \"Thi Mui\",\nfamily = \"Pham\",\nrole = \"ctb\",\nemail = \"thi.mui.pham@rwth-aachen.de\"),\nperson(given = \"Michael\",\nfamily = \"Martini\",\nrole = \"ctb\",\nemail = \"michael.martini1@rwth-aachen.de\"),\nperson(given = \"Ralf-Dieter\",\nfamily = \"Hilgers\",\nrole = c(\"aut\", \"ths\",\"cre\"),\nemail = \"rhilgers@ukaachen.de\"),\nperson(given = \"Nicole\",\nfamily = \"Heussen\",\nrole = c(\"aut\", \"ths\"),\nemail = \"nheussen@ukaachen.de\"),\nperson(given = \"Daniel\",\nfamily = \"Bodden\",\nrole = \"ctb\",\nemail = \"dbodden@ukaachen.de\"))",
  "Maintainer": "Ralf-Dieter Hilgers <rhilgers@ukaachen.de>",
  "Description": "This tool enables the user to choose a randomization\nprocedure based on sound scientific criteria. It comprises the\ngeneration of randomization sequences as well the assessment of\nrandomization procedures based on carefully selected criteria.\nFurthermore, 'randomizeR' provides a function for the\ncomparison of randomization procedures.",
  "License": "GPL (>= 3)",
  "Encoding": "UTF-8",
  "Collate": "'getDesign.R' 'randPar.R' 'pbrPar.R' 'rarPar.R' 'randSeq.R'\n'rarSeq.R' 'GSD-Bias.R' 'abcdPar.R' 'abcdSeq.R'\n'getParameters.R' 'getExpectation.R' 'survEndp.R' 'expEndp.R'\n'normEndp.R' 'endpoint.R' 'util.R' 'getStat.R' 'power.R'\n'imbalance.R' 'corGuess.R' 'logRankDistribution.R' 'doublyF.R'\n'testDec.R' 'doublyT.R' 'chronBias.R' 'selBias.R' 'bias.R'\n'issue.R' 'assess.R' 'bbcdPar.R' 'bbcdSeq.R' 'ebcPar.R'\n'bsdPar.R' 'bsdSeq.R' 'chenPar.R' 'chenSeq.R'\n'chronBiasStepT.R' 'combinedBias.R' 'compare.R' 'crPar.R'\n'crSeq.R' 'createParam.R' 'derFunc.R' 'desFunc.R'\n'getDesFunc.R' 'derringerLs.R' 'derringerRs.R' 'derringerTs.R'\n'desScores.R' 'desirability.R' 'ebcSeq.R' 'evaluate.R'\n'gbcdPar.R' 'gbcdSeq.R' 'hadaPar.R' 'hadaSeq.R' 'maccombo.R'\n'mpPar.R' 'mpSeq.R' 'pbrSeq.R' 'probUnDes.R' 'rtbdSeq.R'\n'rpbrSeq.R' 'randomBlockSeq.R' 'randomizeROverview.R'\n'randomizeRPackage.R' 'rpbrPar.R' 'tbdPar.R' 'rtbdPar.R'\n'saveAssess.R' 'saveRand.R' 'stratifiedAnalysis.R' 'tbdSeq.R'\n'udPar.R' 'udSeq.R'",
  "RoxygenNote": "7.2.3",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-06-02 06:47:28 UTC",
    "User": "root"
  },
  "Author": "David Schindler [aut], Diane Uschner [aut], Denis Razsolkov\n[ctb], Dimitar Mihaylov [ctb], Marcia Viviane Rueckbeil [ctb],\nMartin Manolov [ctb], Thi Mui Pham [ctb], Michael Martini\n[ctb], Ralf-Dieter Hilgers [aut, ths, cre], Nicole Heussen\n[aut, ths], Daniel Bodden [ctb]",
  "Repository": "https://cran.r-universe.dev",
  "Date/Publication": "2023-09-18 21:30:47 UTC",
  "RemoteUrl": "https://github.com/cran/randomizeR",
  "RemoteRef": "HEAD",
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  "MD5sum": "a099b0d5329c71a36b6db4a882c57851",
  "_user": "cran",
  "_type": "src",
  "_file": "randomizeR_3.0.2.tar.gz",
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  "_created": "2026-06-02T06:47:28.000Z",
  "_published": "2026-06-02T06:51:46.218Z",
  "_distro": "noble",
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  "_buildurl": "https://github.com/r-universe/cran/actions/runs/26803265248",
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  "_host": "GitHub-Actions",
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    "id": "a1a068e84f549b602beace7c2d139cec86eff179",
    "author": "Ralf-Dieter Hilgers <rhilgers@ukaachen.de>",
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    "message": "version 3.0.2\n",
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    "description": "Unofficial read-only mirror of all CRAN R packages"
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  "_rbuild": "4.6.0",
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    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/randomizeR.html",
    "extra/readme.html",
    "extra/readme.md",
    "manual.pdf"
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  "_realowner": "cran",
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  "_exports": [
    "a",
    "abcdPar",
    "analyse",
    "assess",
    "bbcdPar",
    "blocks",
    "bsdPar",
    "chenPar",
    "chronBias",
    "coin",
    "combineBias",
    "compare",
    "corGuess",
    "createParam",
    "createSeq",
    "crPar",
    "derFunc",
    "doublyF_values",
    "ebcPar",
    "evaluate",
    "expEndp",
    "gbcdPar",
    "genNcps_new",
    "genSeq",
    "get_p_values_new",
    "getAllSeq",
    "getCorGuesses",
    "getDesFunc",
    "getDesign",
    "getDesScores",
    "getDistributionPars",
    "getExpectation",
    "getProb",
    "getRandList",
    "GSD_allocation",
    "GSD_allocation_seq",
    "hadaPar",
    "imbal",
    "K",
    "method",
    "mpPar",
    "mti",
    "N",
    "normEndp",
    "pbrPar",
    "plot",
    "plotDes",
    "plotEv",
    "plotSeq",
    "probUnDes",
    "randBlocks",
    "rarPar",
    "ratio",
    "rho",
    "rpbrPar",
    "rtbdPar",
    "saveAssess",
    "saveRand",
    "selBias",
    "setPower",
    "summary",
    "survEndp",
    "tbdPar",
    "TV",
    "type",
    "udPar"
  ],
  "_help": [
    {
      "page": "randomizeR-package",
      "title": "Randomization for Clinical Trials",
      "topics": [
        "randomizeR-package",
        "randomizeR"
      ]
    },
    {
      "page": "a",
      "title": "Function returning the adjusting parameter a slot of an S4 object",
      "topics": [
        "a"
      ]
    },
    {
      "page": "abcdPar",
      "title": "Representing Accelerated Biased Coin Design",
      "concept": [
        "randomization procedures"
      ],
      "topics": [
        "abcdPar"
      ]
    },
    {
      "page": "analyse",
      "title": "Creates stratified sequences Compares stratified sequences to their respective non-stratified version under the influence of bias.",
      "topics": [
        "analyse"
      ]
    },
    {
      "page": "assess",
      "title": "Assessing randomization sequences",
      "topics": [
        "assess",
        "assess,randSeq,endpoint-method",
        "assess,randSeq,missing-method"
      ]
    },
    {
      "page": "bbcdPar",
      "title": "Representing Bayesian Biased Coin Design",
      "concept": [
        "randomization procedures"
      ],
      "topics": [
        "bbcdPar"
      ]
    },
    {
      "page": "blocks",
      "title": "Function returning the block slot of an S4 object",
      "topics": [
        "blocks"
      ]
    },
    {
      "page": "bsdPar",
      "title": "Representing Big Stick Design",
      "concept": [
        "randomization procedures"
      ],
      "topics": [
        "bsdPar"
      ]
    },
    {
      "page": "chenPar",
      "title": "Representing Chen's Design",
      "concept": [
        "randomization procedures"
      ],
      "topics": [
        "chenPar"
      ]
    },
    {
      "page": "chronBias",
      "title": "Representing chronological bias",
      "concept": [
        "issues"
      ],
      "topics": [
        "chronBias"
      ]
    },
    {
      "page": "coin",
      "title": "Function returning the coin slot of an S4 object",
      "topics": [
        "coin"
      ]
    },
    {
      "page": "combineBias",
      "title": "Combined bias criterion",
      "concept": [
        "issues"
      ],
      "topics": [
        "combineBias"
      ]
    },
    {
      "page": "compare",
      "title": "Comparison of randomization procedures",
      "topics": [
        "compare",
        "compare,issue,endpoint-method",
        "compare,issue,missing-method"
      ]
    },
    {
      "page": "corGuess",
      "title": "Representing the expected number of correct guesses",
      "concept": [
        "issues"
      ],
      "topics": [
        "corGuess"
      ]
    },
    {
      "page": "createParam",
      "title": "Representing any randomization procedure",
      "concept": [
        "randomization procedures"
      ],
      "topics": [
        "createParam"
      ]
    },
    {
      "page": "createSeq",
      "title": "Query to create a randomization sequence of a particular randomization procedure",
      "topics": [
        "createSeq"
      ]
    },
    {
      "page": "crPar",
      "title": "Representing Complete Randomization",
      "concept": [
        "randomization procedures"
      ],
      "topics": [
        "crPar"
      ]
    },
    {
      "page": "derFunc",
      "title": "Representing Derringer-Suich desirability functions",
      "concept": [
        "desirability topics"
      ],
      "topics": [
        "derFunc"
      ]
    },
    {
      "page": "desirability",
      "title": "Desirability functions within the scope of clinical trials",
      "topics": [
        "desirability"
      ]
    },
    {
      "page": "ebcPar",
      "title": "Representing Efron's Biased Coin Design",
      "concept": [
        "randomization procedures"
      ],
      "topics": [
        "ebcPar"
      ]
    },
    {
      "page": "evaluate",
      "title": "Evaluation of several randomization procedures with respect to certain desirability functions applied to specified issues.",
      "concept": [
        "desirability topics"
      ],
      "topics": [
        "evaluate",
        "evaluate,character-method",
        "evaluate,missing-method"
      ]
    },
    {
      "page": "expEndp",
      "title": "Representation of exponentially distributed endpoints",
      "concept": [
        "endpoint types"
      ],
      "topics": [
        "expEndp"
      ]
    },
    {
      "page": "gbcdPar",
      "title": "Representing Generalized Biased Coin Design",
      "concept": [
        "randomization procedures"
      ],
      "topics": [
        "gbcdPar"
      ]
    },
    {
      "page": "generateAllSequences",
      "title": "Complete set of randomization sequences",
      "topics": [
        "generateAllSequences",
        "getAllSeq",
        "getAllSeq,abcdPar-method",
        "getAllSeq,bbcdPar-method",
        "getAllSeq,bsdPar-method",
        "getAllSeq,chenPar-method",
        "getAllSeq,crPar-method",
        "getAllSeq,ebcPar-method",
        "getAllSeq,gbcdPar-method",
        "getAllSeq,hadaPar-method",
        "getAllSeq,mpPar-method",
        "getAllSeq,pbrPar-method",
        "getAllSeq,rarPar-method",
        "getAllSeq,tbdPar-method",
        "getAllSeq,udPar-method"
      ]
    },
    {
      "page": "generateRandomSequences",
      "title": "Generate random sequences",
      "topics": [
        "generateRandomSequences",
        "genSeq",
        "genSeq,abcdPar,missing,missing-method",
        "genSeq,abcdPar,missing,numeric-method",
        "genSeq,abcdPar,numeric,missing-method",
        "genSeq,abcdPar,numeric,numeric-method",
        "genSeq,bbcdPar,missing,missing-method",
        "genSeq,bbcdPar,missing,numeric-method",
        "genSeq,bbcdPar,numeric,missing-method",
        "genSeq,bbcdPar,numeric,numeric-method",
        "genSeq,bsdPar,missing,missing-method",
        "genSeq,bsdPar,missing,numeric-method",
        "genSeq,bsdPar,numeric,missing-method",
        "genSeq,bsdPar,numeric,numeric-method",
        "genSeq,chenPar,missing,missing-method",
        "genSeq,chenPar,missing,numeric-method",
        "genSeq,chenPar,numeric,missing-method",
        "genSeq,chenPar,numeric,numeric-method",
        "genSeq,crPar,missing,missing-method",
        "genSeq,crPar,missing,numeric-method",
        "genSeq,crPar,numeric,missing-method",
        "genSeq,crPar,numeric,numeric-method",
        "genSeq,ebcPar,missing,missing-method",
        "genSeq,ebcPar,missing,numeric-method",
        "genSeq,ebcPar,numeric,missing-method",
        "genSeq,ebcPar,numeric,numeric-method",
        "genSeq,gbcdPar,missing,missing-method",
        "genSeq,gbcdPar,missing,numeric-method",
        "genSeq,gbcdPar,numeric,missing-method",
        "genSeq,gbcdPar,numeric,numeric-method",
        "genSeq,hadaPar,missing,missing-method",
        "genSeq,hadaPar,missing,numeric-method",
        "genSeq,hadaPar,numeric,missing-method",
        "genSeq,hadaPar,numeric,numeric-method",
        "genSeq,mpPar,missing,missing-method",
        "genSeq,mpPar,missing,numeric-method",
        "genSeq,mpPar,numeric,missing-method",
        "genSeq,mpPar,numeric,numeric-method",
        "genSeq,pbrPar,missing,missing-method",
        "genSeq,pbrPar,missing,numeric-method",
        "genSeq,pbrPar,numeric,missing-method",
        "genSeq,pbrPar,numeric,numeric-method",
        "genSeq,rarPar,missing,missing-method",
        "genSeq,rarPar,missing,numeric-method",
        "genSeq,rarPar,numeric,missing-method",
        "genSeq,rarPar,numeric,numeric-method",
        "genSeq,rpbrPar,missing,missing-method",
        "genSeq,rpbrPar,missing,numeric-method",
        "genSeq,rpbrPar,numeric,missing-method",
        "genSeq,rpbrPar,numeric,numeric-method",
        "genSeq,rtbdPar,missing,missing-method",
        "genSeq,rtbdPar,missing,numeric-method",
        "genSeq,rtbdPar,numeric,missing-method",
        "genSeq,rtbdPar,numeric,numeric-method",
        "genSeq,tbdPar,missing,missing-method",
        "genSeq,tbdPar,missing,numeric-method",
        "genSeq,tbdPar,numeric,missing-method",
        "genSeq,tbdPar,numeric,numeric-method",
        "genSeq,udPar,missing,missing-method",
        "genSeq,udPar,missing,numeric-method",
        "genSeq,udPar,numeric,missing-method",
        "genSeq,udPar,numeric,numeric-method"
      ]
    },
    {
      "page": "genNcps_new",
      "title": "Calculation of the NCPs of each randomization sequence for the doubly noncentral t-distribution",
      "topics": [
        "genNcps_new"
      ]
    },
    {
      "page": "get_p_values_new",
      "title": "Calculating p values",
      "topics": [
        "get_p_values_new"
      ]
    },
    {
      "page": "getCorGuesses",
      "title": "Matrix of the guesses of the investigator",
      "topics": [
        "getCorGuesses"
      ]
    },
    {
      "page": "getDesFunc",
      "title": "Type of Desirability function",
      "topics": [
        "getDesFunc",
        "getDesFunc,derringerLs-method",
        "getDesFunc,derringerRs-method",
        "getDesFunc,derringerTs-method"
      ]
    },
    {
      "page": "getDesign",
      "title": "Design of a randomization procedure",
      "topics": [
        "getDesign",
        "getDesign,abcdPar-method",
        "getDesign,abcdSeq-method",
        "getDesign,bbcdPar-method",
        "getDesign,bbcdSeq-method",
        "getDesign,bsdPar-method",
        "getDesign,bsdSeq-method",
        "getDesign,chenPar-method",
        "getDesign,chenSeq-method",
        "getDesign,crPar-method",
        "getDesign,crSeq-method",
        "getDesign,ebcPar-method",
        "getDesign,ebcSeq-method",
        "getDesign,gbcdPar-method",
        "getDesign,gbcdSeq-method",
        "getDesign,hadaPar-method",
        "getDesign,hadaSeq-method",
        "getDesign,mpPar-method",
        "getDesign,mpSeq-method",
        "getDesign,pbrPar-method",
        "getDesign,pbrSeq-method",
        "getDesign,rarPar-method",
        "getDesign,rarSeq-method",
        "getDesign,rpbrPar-method",
        "getDesign,rRpbrSeq-method",
        "getDesign,rRtbdSeq-method",
        "getDesign,rtbdPar-method",
        "getDesign,tbdPar-method",
        "getDesign,tbdSeq-method",
        "getDesign,udPar-method",
        "getDesign,udSeq-method"
      ]
    },
    {
      "page": "getDesScores",
      "title": "Applying desirability functions on issues of individual randomization sequences",
      "concept": [
        "desirability topics"
      ],
      "topics": [
        "getDesScores",
        "getDesScores,assessment,missing-method",
        "getDesScores,assessment,numeric-method"
      ]
    },
    {
      "page": "getDistributionPars",
      "title": "Get distribution parameters of a randomization list",
      "topics": [
        "getDistributionPars",
        "getDistributionPars,randSeq,chronBias,survEndp-method",
        "getDistributionPars,randSeq,combinedBias,survEndp-method",
        "getDistributionPars,randSeq,combinedBiasStepTrend,survEndp-method",
        "getDistributionPars,randSeq,missing,survEndp-method",
        "getDistributionPars,randSeq,selBias,survEndp-method"
      ]
    },
    {
      "page": "getExpectation",
      "title": "Get expectations of a randomization list",
      "topics": [
        "getExpectation",
        "getExpectation,randSeq,chronBias,expEndp-method",
        "getExpectation,randSeq,chronBias,missing-method",
        "getExpectation,randSeq,chronBias,normEndp-method",
        "getExpectation,randSeq,chronBias,survEndp-method",
        "getExpectation,randSeq,combinedBias,expEndp-method",
        "getExpectation,randSeq,combinedBias,normEndp-method",
        "getExpectation,randSeq,combinedBias,survEndp-method",
        "getExpectation,randSeq,combinedBiasStepTrend,expEndp-method",
        "getExpectation,randSeq,combinedBiasStepTrend,normEndp-method",
        "getExpectation,randSeq,combinedBiasStepTrend,survEndp-method",
        "getExpectation,randSeq,missing,expEndp-method",
        "getExpectation,randSeq,missing,normEndp-method",
        "getExpectation,randSeq,missing,survEndp-method",
        "getExpectation,randSeq,power,normEndp-method",
        "getExpectation,randSeq,selBias,expEndp-method",
        "getExpectation,randSeq,selBias,missing-method",
        "getExpectation,randSeq,selBias,normEndp-method",
        "getExpectation,randSeq,selBias,survEndp-method"
      ]
    },
    {
      "page": "getProbabilities",
      "title": "Theoretical probability for randomization sequences",
      "topics": [
        "calcProb",
        "calculateProbabilities",
        "getProb",
        "getProb,abcdSeq-method",
        "getProb,bbcdSeq-method",
        "getProb,bsdSeq-method",
        "getProb,chenSeq-method",
        "getProb,crSeq-method",
        "getProb,ebcSeq-method",
        "getProb,gbcdSeq-method",
        "getProb,hadaSeq-method",
        "getProb,mpSeq-method",
        "getProb,pbrSeq-method",
        "getProb,rarSeq-method",
        "getProb,tbdSeq-method",
        "getProb,udSeq-method",
        "getProbabilities"
      ]
    },
    {
      "page": "getRandomizationList",
      "title": "Accessor function for the randomization list",
      "topics": [
        "getRandList",
        "getRandomizationList"
      ]
    },
    {
      "page": "GSD_allocation",
      "title": "Calculates the Type I error for different randomization sequences from a randomization procedure for a group sequential design",
      "topics": [
        "GSD_allocation"
      ]
    },
    {
      "page": "GSD_allocation_seq",
      "title": "Calculates the Type I error for a randomization sequence in a group sequential design",
      "topics": [
        "GSD_allocation_seq"
      ]
    },
    {
      "page": "hadaPar",
      "title": "Representing Hadamard Randomization",
      "concept": [
        "randomization procedures"
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      "topics": [
        "hadaPar"
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    },
    {
      "page": "imbal",
      "title": "Representing the allocation imbalance",
      "concept": [
        "issues"
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      "topics": [
        "imbal"
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    },
    {
      "page": "issue",
      "title": "Assessment criteria for clinical trials",
      "concept": [
        "issues"
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      "topics": [
        "issue",
        "issues"
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    {
      "page": "K",
      "title": "Function returning the number of trial arms slot of an S4 object",
      "topics": [
        "K"
      ]
    },
    {
      "page": "lambda",
      "title": "Method returning the rate parameter of an expEndp S4 object",
      "topics": [
        "lambda"
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    },
    {
      "page": "method",
      "title": "Function returning the method of an S4 object",
      "topics": [
        "method"
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    },
    {
      "page": "mpPar",
      "title": "Representing Maximal Procedure",
      "concept": [
        "randomization procedures"
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      "topics": [
        "mpPar"
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    },
    {
      "page": "mti",
      "title": "Function returning the MTI slot of an S4 object",
      "topics": [
        "mti"
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    },
    {
      "page": "mu",
      "title": "Access the expectation value slot of a normEndp S4 object",
      "topics": [
        "mu"
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    {
      "page": "N",
      "title": "Function returning the sample size slot of an S4 object",
      "topics": [
        "N"
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    {
      "page": "normEndp",
      "title": "Representation of normally distributed endpoints",
      "concept": [
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      "page": "overview",
      "title": "Overview over the parameters used in the 'randomizeR' package",
      "topics": [
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    {
      "page": "pbrPar",
      "title": "Representing Permuted Block Randomization",
      "concept": [
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    {
      "page": "plot",
      "title": "Generic plotting of comparison objects",
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        "plot,comparison,missing-method"
      ]
    },
    {
      "page": "plotDes",
      "title": "desScore plotting",
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        "desirability topics"
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      "page": "plotEv",
      "title": "Evaluation plotting",
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    {
      "page": "plotSeq",
      "title": "Sequence plotting",
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      "page": "probUnDes",
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      "title": "Function returning the block slot of an S4 object",
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      "page": "randPar",
      "title": "Settings for randomization procedures",
      "topics": [
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    {
      "page": "randSeq-class",
      "title": "An S4 Class for the representation of randomization sequences",
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    {
      "page": "rarPar",
      "title": "Representing Random Allocation Rule",
      "concept": [
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      "page": "ratio",
      "title": "Function returning the allocation ratio slot of an S4 object",
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        "ratio"
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      "page": "rho",
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    {
      "page": "rpbrPar",
      "title": "Representing Randomized Permuted Block Randomization",
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        "randomization procedures"
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    {
      "page": "rtbdPar",
      "title": "Representing Randomized Truncated Binomial Design",
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      "page": "saveAssess",
      "title": "Saving an assess object",
      "concept": [
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      "page": "saveRand",
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      "concept": [
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      "page": "scale",
      "title": "Method returning the scale parameter of an survEndp S4 object",
      "topics": [
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      "page": "seed",
      "title": "Function returning the allocation seed slot of an object",
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      "page": "selBias",
      "title": "Representing selection bias",
      "concept": [
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      "page": "setPower",
      "title": "Representing the power",
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      "page": "shape",
      "title": "Method returning the shape parameter of an survEndp S4 object",
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      "page": "sigma",
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      "page": "summary",
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      "page": "survEndp",
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      "page": "tbdPar",
      "title": "Representing Truncated Binomal Design",
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