{
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  "Package": "qtl2",
  "Version": "0.42",
  "Date": "2026-06-08",
  "Title": "Quantitative Trait Locus Mapping in Experimental Crosses",
  "Description": "Provides a set of tools to perform quantitative trait\nlocus (QTL) analysis in experimental crosses. It is a\nreimplementation of the 'R/qtl' package to better handle\nhigh-dimensional data and complex cross designs. Broman et al.\n(2019) <doi:10.1534/genetics.118.301595>.",
  "Author": "Karl W Broman [aut, cre] (ORCID:\n<https://orcid.org/0000-0002-4914-6671>), R Core Team [ctb]",
  "Maintainer": "Karl W Broman <broman@wisc.edu>",
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  "Copyright": "Code for Brent's method for univariate function optimization\nwas taken from R 3.2.2 (Copyright 1995, 1996 Robert Gentleman\nand Ross Ihaka, Copyright 2003-2004 The R Foundation, Copyright\n1998-2014 The R Core Team).",
  "License": "GPL-3",
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  "_exports": [
    "add_threshold",
    "align_scan1_map",
    "batch_cols",
    "batch_vec",
    "bayes_int",
    "calc_entropy",
    "calc_errorlod",
    "calc_geno_freq",
    "calc_genoprob",
    "calc_grid",
    "calc_het",
    "calc_hotspots",
    "calc_kinship",
    "calc_raw_founder_maf",
    "calc_raw_geno_freq",
    "calc_raw_het",
    "calc_raw_maf",
    "calc_sdp",
    "cbind_expand",
    "check_cross2",
    "chisq_colpairs",
    "chr_lengths",
    "chr_names",
    "clean",
    "clean_genoprob",
    "clean_scan1",
    "compare_founder_geno",
    "compare_geno",
    "compare_genoprob",
    "compare_maps",
    "convert2cross2",
    "count_xo",
    "covar_names",
    "create_gene_query_func",
    "create_snpinfo",
    "create_variant_query_func",
    "decomp_kinship",
    "drop_markers",
    "drop_nullmarkers",
    "est_herit",
    "est_map",
    "find_dup_markers",
    "find_ibd_segments",
    "find_index_snp",
    "find_map_gaps",
    "find_marker",
    "find_markerpos",
    "find_peaks",
    "fit1",
    "founders",
    "fread_csv",
    "fread_csv_numer",
    "genoprob_to_alleleprob",
    "genoprob_to_snpprob",
    "get_common_ids",
    "get_x_covar",
    "guess_phase",
    "ind_ids",
    "ind_ids_covar",
    "ind_ids_geno",
    "ind_ids_gnp",
    "ind_ids_pheno",
    "index_snps",
    "insert_pseudomarkers",
    "interp_genoprob",
    "interp_map",
    "invert_sdp",
    "locate_xo",
    "lod_int",
    "map_to_grid",
    "marker_names",
    "mat2strata",
    "max_compare_geno",
    "max_scan1",
    "maxlod",
    "maxmarg",
    "n_chr",
    "n_covar",
    "n_founders",
    "n_ind",
    "n_ind_covar",
    "n_ind_geno",
    "n_ind_gnp",
    "n_ind_pheno",
    "n_mar",
    "n_missing",
    "n_pheno",
    "n_phenocovar",
    "n_typed",
    "pheno_names",
    "phenocovar_names",
    "plot_ci",
    "plot_cistrans",
    "plot_coef",
    "plot_coefCC",
    "plot_colorscale",
    "plot_compare_geno",
    "plot_genes",
    "plot_geno",
    "plot_genoprob",
    "plot_genoprobcomp",
    "plot_lodpeaks",
    "plot_onegeno",
    "plot_peaks",
    "plot_pxg",
    "plot_scan1",
    "plot_scan1_heatmap",
    "plot_sdp",
    "plot_snpasso",
    "predict_snpgeno",
    "probs_to_grid",
    "pull_genoprobint",
    "pull_genoprobpos",
    "pull_markers",
    "qtl2version",
    "read_cross2",
    "read_pheno",
    "recode_snps",
    "reduce_map_gaps",
    "reduce_markers",
    "replace_ids",
    "scale_kinship",
    "scan1",
    "scan1blup",
    "scan1coef",
    "scan1max",
    "scan1perm",
    "scan1snps",
    "sdp2char",
    "sim_geno",
    "smooth_gmap",
    "subset_scan1",
    "summary_compare_geno",
    "summary_scan1perm",
    "top_snps",
    "tot_mar",
    "unsmooth_gmap",
    "viterbi",
    "write_control_file",
    "xpos_scan1",
    "zip_datafiles"
  ],
  "_datasets": [
    {
      "name": "CCaltcolors",
      "title": "Collaborative Cross colors",
      "object": "CCaltcolors",
      "class": [
        "character"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "CCcolors",
      "title": "Collaborative Cross colors",
      "object": "CCcolors",
      "class": [
        "character"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "CCorigcolors",
      "title": "Collaborative Cross colors",
      "object": "CCorigcolors",
      "class": [
        "character"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    }
  ],
  "_help": [
    {
      "page": "add_threshold",
      "title": "Add thresholds to genome scan plot",
      "topics": [
        "add_threshold"
      ]
    },
    {
      "page": "basic_summaries",
      "title": "Basic summaries of a cross2 object",
      "topics": [
        "basic_summaries",
        "chr_names",
        "covar_names",
        "founders",
        "ind_ids",
        "ind_ids_covar",
        "ind_ids_geno",
        "ind_ids_gnp",
        "ind_ids_pheno",
        "marker_names",
        "n_chr",
        "n_covar",
        "n_founders",
        "n_ind",
        "n_ind_covar",
        "n_ind_geno",
        "n_ind_gnp",
        "n_ind_pheno",
        "n_mar",
        "n_pheno",
        "n_phenocovar",
        "phenocovar_names",
        "pheno_names",
        "tot_mar"
      ]
    },
    {
      "page": "batch_cols",
      "title": "Batch columns by pattern of missing values",
      "topics": [
        "batch_cols"
      ]
    },
    {
      "page": "batch_vec",
      "title": "Split vector into batches",
      "topics": [
        "batch_vec"
      ]
    },
    {
      "page": "bayes_int",
      "title": "Calculate Bayes credible intervals",
      "topics": [
        "bayes_int"
      ]
    },
    {
      "page": "calc_entropy",
      "title": "Calculate entropy of genotype probability distribution",
      "topics": [
        "calc_entropy"
      ]
    },
    {
      "page": "calc_errorlod",
      "title": "Calculate genotyping error LOD scores",
      "topics": [
        "calc_errorlod"
      ]
    },
    {
      "page": "calc_geno_freq",
      "title": "Calculate genotype frequencies",
      "topics": [
        "calc_geno_freq"
      ]
    },
    {
      "page": "calc_genoprob",
      "title": "Calculate conditional genotype probabilities",
      "topics": [
        "calc_genoprob"
      ]
    },
    {
      "page": "calc_grid",
      "title": "Calculate indicators of which marker/pseudomarker positions are along a fixed grid",
      "topics": [
        "calc_grid"
      ]
    },
    {
      "page": "calc_het",
      "title": "Calculate heterozygosities",
      "topics": [
        "calc_het"
      ]
    },
    {
      "page": "calc_hotspots",
      "title": "Calculate QTL hotspots",
      "topics": [
        "calc_hotspots"
      ]
    },
    {
      "page": "calc_kinship",
      "title": "Calculate kinship matrix",
      "topics": [
        "calc_kinship"
      ]
    },
    {
      "page": "calc_raw_founder_maf",
      "title": "Calculate founder minor allele frequencies from raw SNP genotypes",
      "topics": [
        "calc_raw_founder_maf"
      ]
    },
    {
      "page": "calc_raw_geno_freq",
      "title": "Calculate genotype frequencies from raw SNP genotypes",
      "topics": [
        "calc_raw_geno_freq"
      ]
    },
    {
      "page": "calc_raw_het",
      "title": "Calculate estimated heterozygosity from raw SNP genotypes",
      "topics": [
        "calc_raw_het"
      ]
    },
    {
      "page": "calc_raw_maf",
      "title": "Calculate minor allele frequency from raw SNP genotypes",
      "topics": [
        "calc_raw_maf"
      ]
    },
    {
      "page": "calc_sdp",
      "title": "Calculate strain distribution pattern from SNP genotypes",
      "topics": [
        "calc_sdp"
      ]
    },
    {
      "page": "cbind_expand",
      "title": "Combine matrices by columns, expanding and aligning rows",
      "topics": [
        "cbind_expand"
      ]
    },
    {
      "page": "cbind.calc_genoprob",
      "title": "Join genotype probabilities for different chromosomes",
      "topics": [
        "cbind.calc_genoprob"
      ]
    },
    {
      "page": "cbind.phasedgeno",
      "title": "Join phased genotype results for different chromosomes",
      "topics": [
        "cbind.phasedgeno"
      ]
    },
    {
      "page": "cbind.scan1",
      "title": "Join genome scan results for different phenotypes.",
      "topics": [
        "cbind.scan1"
      ]
    },
    {
      "page": "cbind.scan1perm",
      "title": "Combine columns from multiple scan1 permutation results",
      "topics": [
        "cbind.scan1perm"
      ]
    },
    {
      "page": "cbind.sim_geno",
      "title": "Join genotype imputations for different chromosomes",
      "topics": [
        "cbind.sim_geno"
      ]
    },
    {
      "page": "cbind.viterbi",
      "title": "Join viterbi results for different chromosomes",
      "topics": [
        "cbind.viterbi"
      ]
    },
    {
      "page": "CCcolors",
      "title": "Collaborative Cross colors",
      "topics": [
        "CCaltcolors",
        "CCcolors",
        "CCorigcolors"
      ]
    },
    {
      "page": "check_cross2",
      "title": "Check a cross2 object",
      "topics": [
        "check_cross2"
      ]
    },
    {
      "page": "chisq_colpairs",
      "title": "Chi-square test on all pairs of columns",
      "topics": [
        "chisq_colpairs"
      ]
    },
    {
      "page": "chr_lengths",
      "title": "Calculate chromosome lengths",
      "topics": [
        "chr_lengths"
      ]
    },
    {
      "page": "clean",
      "title": "Clean an object",
      "topics": [
        "clean"
      ]
    },
    {
      "page": "clean_genoprob",
      "title": "Clean genotype probabilities",
      "topics": [
        "clean.calc_genoprob",
        "clean_genoprob"
      ]
    },
    {
      "page": "clean_scan1",
      "title": "Clean scan1 output",
      "topics": [
        "clean.scan1",
        "clean_scan1"
      ]
    },
    {
      "page": "compare_founder_geno",
      "title": "Compare founders genotype data",
      "topics": [
        "compare_founder_geno"
      ]
    },
    {
      "page": "compare_geno",
      "title": "Compare individuals' genotype data",
      "topics": [
        "compare_geno"
      ]
    },
    {
      "page": "compare_genoprob",
      "title": "Compare two sets of genotype probabilities",
      "topics": [
        "compare_genoprob"
      ]
    },
    {
      "page": "compare_maps",
      "title": "Compare two marker maps",
      "topics": [
        "compare_maps"
      ]
    },
    {
      "page": "convert2cross2",
      "title": "Convert R/qtl cross object to new format",
      "topics": [
        "convert2cross2"
      ]
    },
    {
      "page": "count_xo",
      "title": "Count numbers of crossovers",
      "topics": [
        "count_xo"
      ]
    },
    {
      "page": "create_gene_query_func",
      "title": "Create a function to query genes",
      "topics": [
        "create_gene_query_func"
      ]
    },
    {
      "page": "create_snpinfo",
      "title": "Create snp information table for a cross",
      "topics": [
        "create_snpinfo"
      ]
    },
    {
      "page": "create_variant_query_func",
      "title": "Create a function to query variants",
      "topics": [
        "create_variant_query_func"
      ]
    },
    {
      "page": "decomp_kinship",
      "title": "Calculate eigen decomposition of kinship matrix",
      "topics": [
        "decomp_kinship"
      ]
    },
    {
      "page": "drop_markers",
      "title": "Drop markers from a cross2 object",
      "topics": [
        "drop_markers"
      ]
    },
    {
      "page": "drop_nullmarkers",
      "title": "Drop markers with no genotype data",
      "topics": [
        "drop_nullmarkers"
      ]
    },
    {
      "page": "est_herit",
      "title": "Estimate heritability with a linear mixed model",
      "topics": [
        "est_herit"
      ]
    },
    {
      "page": "est_map",
      "title": "Estimate genetic maps",
      "topics": [
        "est_map"
      ]
    },
    {
      "page": "find_dup_markers",
      "title": "Find markers with identical genotype data",
      "topics": [
        "find_dup_markers"
      ]
    },
    {
      "page": "find_ibd_segments",
      "title": "Find IBD segments for a set of strains",
      "topics": [
        "find_ibd_segments"
      ]
    },
    {
      "page": "find_index_snp",
      "title": "Find name of indexed snp",
      "topics": [
        "find_index_snp"
      ]
    },
    {
      "page": "find_map_gaps",
      "title": "Find gaps in a genetic map",
      "topics": [
        "find_map_gaps"
      ]
    },
    {
      "page": "find_marker",
      "title": "Find markers by chromosome position",
      "topics": [
        "find_marker"
      ]
    },
    {
      "page": "find_markerpos",
      "title": "Find positions of markers",
      "topics": [
        "find_markerpos"
      ]
    },
    {
      "page": "find_peaks",
      "title": "Find peaks in a set of LOD curves",
      "topics": [
        "find_peaks"
      ]
    },
    {
      "page": "fit1",
      "title": "Fit single-QTL model at a single position",
      "topics": [
        "fit1"
      ]
    },
    {
      "page": "fread_csv",
      "title": "Read a csv file",
      "topics": [
        "fread_csv"
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    {
      "page": "fread_csv_numer",
      "title": "Read a csv file that has numeric columns",
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      "page": "genoprob_to_alleleprob",
      "title": "Convert genotype probabilities to allele probabilities",
      "topics": [
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      "page": "genoprob_to_snpprob",
      "title": "Convert genotype probabilities to SNP probabilities",
      "topics": [
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      "page": "get_common_ids",
      "title": "Get common set of IDs from objects",
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      ]
    },
    {
      "page": "get_x_covar",
      "title": "Get X chromosome covariates",
      "topics": [
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    {
      "page": "guess_phase",
      "title": "Guess phase of imputed genotypes",
      "topics": [
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      ]
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    {
      "page": "index_snps",
      "title": "Create index of equivalent SNPs",
      "topics": [
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      ]
    },
    {
      "page": "insert_pseudomarkers",
      "title": "Insert pseudomarkers into a marker map",
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    },
    {
      "page": "interp_genoprob",
      "title": "Interpolate genotype probabilities",
      "topics": [
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      "page": "interp_map",
      "title": "Interpolate between maps",
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      "page": "invert_sdp",
      "title": "Calculate SNP genotype matrix from strain distribution patterns",
      "topics": [
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    {
      "page": "locate_xo",
      "title": "Locate crossovers",
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      "page": "lod_int",
      "title": "Calculate LOD support intervals",
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    {
      "page": "map_to_grid",
      "title": "Subset a map to positions on a grid",
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      "title": "Find pair with most similar genotypes",
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      "title": "Find position with maximum LOD score",
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      "title": "Overall maximum LOD score",
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      "title": "Find genotypes with maximum marginal probabilities",
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      "page": "plot_ci",
      "title": "Effect plot with multiple CIs for different groups",
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      "title": "cis-trans plot for eQTL results",
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      "title": "Plot QTL effects along chromosome",
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      "title": "Heat map color scale",
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      "title": "Plot of compare_geno object.",
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      "title": "Plot gene locations for a genomic interval",
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      "title": "Plot multiple individuals' genome-wide genotypes",
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      "title": "Plot genotype probabilities for one individual on one chromosome.",
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      "title": "Plot comparison of two sets of genotype probabilities",
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      "title": "Plot LOD scores vs QTL peak locations",
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      "title": "Plot one individual's genome-wide genotypes",
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      "title": "Plot QTL peak locations",
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      "title": "Plot phenotype vs genotype",
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      "title": "Plot a genome scan",
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      "title": "plot strain distribution patterns for SNPs",
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      "title": "Plot SNP associations",
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      "title": "Predict SNP genotypes",
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      "title": "Print a cross2 object",
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      "title": "Join genome scan results for different chromosomes.",
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      "title": "Genome scan with a single-QTL model",
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      "title": "Calculate BLUPs of QTL effects in scan along one chromosome",
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      "title": "Calculate QTL effects in scan along one chromosome",
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      "title": "Single-QTL genome scan at imputed SNPs",
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      "title": "Simulate genotypes given observed marker data",
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