{ "_id": "6a1f349db401979e73428416", "Package": "ordcrm", "Title": "Likelihood-Based Continual Reassessment Method (CRM) Dose\nFinding Designs", "Version": "1.0.0", "Date": "2016-11-01", "Author": "Emily V. Dressler, PhD Zhengyan Huang", "Maintainer": "Emily V. Dressler ", "Description": "Provides the setup and calculations needed to run a\nlikelihood-based continual reassessment method (CRM) dose\nfinding trial and performs simulations to assess design\nperformance under various scenarios. 3 dose finding designs are\nincluded in this package: ordinal proportional odds model (POM)\nCRM, ordinal continuation ratio (CR) model CRM, and the binary\n2-parameter logistic model CRM. These functions allow\ncustomization of design characteristics to vary sample size,\ncohort sizes, target dose-limiting toxicity (DLT) rates,\ndiscrete or continuous dose levels, combining ordinal grades 0\nand 1 into one category, and incorporate safety and/or stopping\nrules. For POM and CR model designs, ordinal toxicity grades\nare specified by common terminology criteria for adverse events\n(CTCAE) version 4.0. Function 'pseudodata' creates the\nnecessary starting models for these 3 designs, and function\n'nextdose' estimates the next dose to test in a cohort of\npatients for a target DLT rate. We also provide the function\n'crmsimulations' to assess the performance of these 3 dose\nfinding designs under various scenarios.", "License": "GPL (>= 2)", "Encoding": "UTF-8", "RoxygenNote": "5.0.1", "NeedsCompilation": "no", "Packaged": { "Date": "2026-05-15 06:46:35 UTC", "User": "root" }, "Repository": "https://cran.r-universe.dev", "Date/Publication": "2016-11-04 23:54:11 UTC", "RemoteUrl": "https://github.com/cran/ordcrm", "RemoteRef": "HEAD", "RemoteSha": "114a63b5075eea5b7bbf49ae8c44b428c1861cad", "MD5sum": "353c28f9e660e2d13029b4673cb5fe0c", "_user": "cran", "_type": "src", "_file": "ordcrm_1.0.0.tar.gz", "_fileid": "cc5017f6eb47cfbeaabb89e974479a4c8cf6850bf98d1f49c9cfd8a362b09c70", "_filesize": 204955, "_sha256": "cc5017f6eb47cfbeaabb89e974479a4c8cf6850bf98d1f49c9cfd8a362b09c70", "_created": "2026-05-15T06:46:35.000Z", "_published": "2026-06-02T19:53:01.073Z", "_distro": "noble", "_jobs": [ { "job": 79159088512, "time": 130, "config": "linux-devel-x86_64", "r": "4.7.0", "check": "OK", "artifact": "7011673741" }, { "job": 79159088370, "time": 128, "config": "linux-release-x86_64", "r": "4.6.0", "check": "OK", "artifact": "7011673355" }, { "job": 79159087948, "time": 230, "config": "source", "r": "4.6.0", "check": "OK", "artifact": "7011644415" }, { "job": 79159087809, "time": 109, "config": "wasm-release", "r": "4.6.0", "check": "OK", "artifact": "7368276438" } ], "_buildurl": "https://github.com/r-universe/cran/actions/runs/25904392624", "_status": "success", "_host": "GitHub-Actions", "_upstream": "https://github.com/cran/ordcrm", "_commit": { "id": "114a63b5075eea5b7bbf49ae8c44b428c1861cad", "author": "Emily V. Dressler ", "committer": "cran-robot ", "message": "version 1.0.0\n", "time": 1478303651 }, "_maintainer": { "name": "Emily V. Dressler", "email": "emilyvdressler@gmail.com" }, "_registered": true, "_dependencies": [ { "package": "R", "version": ">= 3.3.1", "role": "Depends" }, { "package": "stats", "role": "Depends" }, { "package": "graphics", "role": "Depends" }, { "package": "rms", "role": "Imports" } ], "_owner": "cran", "_selfowned": false, "_usedby": 0, "_updates": [], "_tags": [], "_stars": 0, "_userbio": { "uuid": 6899542, "type": "organization", "name": "cran", "description": "Unofficial read-only mirror of all CRAN R packages" }, "_downloads": { "count": 171, "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/ordcrm" }, "_searchresults": 3, "_rbuild": "4.6.0", "_assets": [ "extra/citation.cff", "extra/citation.html", "extra/citation.json", "extra/citation.txt", "extra/contents.json", "extra/NEWS.html", "extra/NEWS.txt", "extra/ordcrm.html", "extra/readme.html", "extra/readme.md", "manual.pdf" ], "_realowner": "cran", "_cranurl": false, "_releases": [ { "version": "1.0.0", "date": "2016-11-04" } ], "_exports": [ "crmsimulations", "nextdose", "pseudodata" ], "_help": [ { "page": "crmsimulations", "title": "Simulations to Assess operating characteristics of proportional odds model (POM), continuation ratio (CR) Model, and binary CRM Designs", "topics": [ "crmsimulations" ] }, { "page": "nextdose", "title": "Estimates the updated model and next dose to be tested for the Proportional Odds Model (POM), Continuation Ratio (CR) Model CRM, or binary 2-parameter logistic model CRM.", "topics": [ "nextdose" ] }, { "page": "pseudodata", "title": "Pseudodata for Likelihood-Based Continual Reassessment Method (CRM) Dose Finding Designs", "topics": [ "pseudodata" ] } ], "_readme": "https://github.com/cran/ordcrm/raw/HEAD/README.md", "_rundeps": [ "backports", "base64enc", "bslib", "cachem", "checkmate", "cli", "cluster", "codetools", "colorspace", "cpp11", "data.table", "digest", "evaluate", "farver", "fastmap", "fontawesome", "foreign", "Formula", "fs", "ggplot2", "glue", "gridExtra", "gtable", "highr", "Hmisc", "htmlTable", "htmltools", "htmlwidgets", "isoband", "jquerylib", "jsonlite", "knitr", "labeling", "lattice", "lifecycle", "magrittr", "MASS", "Matrix", "MatrixModels", "memoise", "mime", "multcomp", "mvtnorm", "nlme", "nnet", "polspline", "quantreg", "R6", "rappdirs", "RColorBrewer", "rlang", "rmarkdown", "rms", "rpart", "rstudioapi", "S7", "sandwich", "sass", "scales", "SparseM", "stringi", "stringr", "survival", "TH.data", "tinytex", "vctrs", "viridisLite", "withr", "xfun", "yaml", "zoo" ], "_score": 1.6989700043360187, "_indexed": true, "_nocasepkg": "ordcrm", "_universes": [ "cran" ], "_binaries": [ { "r": "4.7.0", "os": "linux", "version": "1.0.0", "date": "2026-05-15T06:48:45.000Z", "distro": "noble", "commit": "114a63b5075eea5b7bbf49ae8c44b428c1861cad", "fileid": "b639149adc74dca71e58bdc67aa3c0bd2702b46396c9c41dba102a53835e5e33", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/cran/actions/runs/25904392624" }, { "r": "4.6.0", "os": "linux", "version": "1.0.0", "date": "2026-05-15T06:48:43.000Z", "distro": "noble", "commit": "114a63b5075eea5b7bbf49ae8c44b428c1861cad", "fileid": "86e264d76635007c8fbb11963866a7b278c868a459a8789b7cb7a2f40dd0031c", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/cran/actions/runs/25904392624" }, { "r": "4.6.0", "os": "wasm", "version": "1.0.0", "date": "2026-06-02T19:52:47.000Z", "commit": "114a63b5075eea5b7bbf49ae8c44b428c1861cad", "fileid": "49b4588b5d4a27c7d11d01ce1b6942513569c3ecbef593f11cf50914f7329888", "status": "success", "buildurl": "https://github.com/r-universe/cran/actions/runs/25904392624" } ] }