{ "_id": "6acf5582e2d863f662950c7d", "Package": "ordcrm", "Title": "Likelihood-Based Continual Reassessment Method (CRM) Dose\nFinding Designs", "Version": "1.0.0", "Date": "2016-11-01", "Author": "Emily V. Dressler, PhD Zhengyan Huang", "Maintainer": "Emily V. Dressler ", "Description": "Provides the setup and calculations needed to run a\nlikelihood-based continual reassessment method (CRM) dose\nfinding trial and performs simulations to assess design\nperformance under various scenarios. 3 dose finding designs are\nincluded in this package: ordinal proportional odds model (POM)\nCRM, ordinal continuation ratio (CR) model CRM, and the binary\n2-parameter logistic model CRM. These functions allow\ncustomization of design characteristics to vary sample size,\ncohort sizes, target dose-limiting toxicity (DLT) rates,\ndiscrete or continuous dose levels, combining ordinal grades 0\nand 1 into one category, and incorporate safety and/or stopping\nrules. For POM and CR model designs, ordinal toxicity grades\nare specified by common terminology criteria for adverse events\n(CTCAE) version 4.0. Function 'pseudodata' creates the\nnecessary starting models for these 3 designs, and function\n'nextdose' estimates the next dose to test in a cohort of\npatients for a target DLT rate. We also provide the function\n'crmsimulations' to assess the performance of these 3 dose\nfinding designs under various scenarios.", "License": "GPL (>= 2)", "Encoding": "UTF-8", "RoxygenNote": "5.0.1", "NeedsCompilation": "no", "Packaged": { "Date": "2026-10-14 10:09:29 UTC", "User": "root" }, "Repository": "https://cran.r-universe.dev", "Date/Publication": "2016-11-04 23:54:11 UTC", "RemoteUrl": "https://github.com/cran/ordcrm", "RemoteRef": "HEAD", "RemoteSha": "114a63b5075eea5b7bbf49ae8c44b428c1861cad", "_user": "cran", "_type": "src", "_file": "ordcrm_1.0.0.tar.gz", "_fileid": "https://r2.ropensci.org/4541efaaec1f2e8b93dc5962663d06eb50d5434d6d0375cedf4e779a88951022", "_filesize": 204708, "_sha256": "4541efaaec1f2e8b93dc5962663d06eb50d5434d6d0375cedf4e779a88951022", "_expires": "2027-01-22T10:12:17.000Z", "_created": "2026-10-14T10:09:29.000Z", "_published": "2026-10-14T10:12:18.775Z", "_buildurl": "https://github.com/r-universe/cran/actions/runs/38547211317", "_status": "success", "_host": "GitHub-Actions", "_jobs": [ { "job": 115797478957, "time": 122, "config": "linux-devel-x86_64", "r": "4.7.0", "check": "OK", "artifact": "11884987779" }, { "job": 115797479008, "time": 130, "config": "linux-release-x86_64", "r": "4.6.1", "check": "OK", "artifact": "11884997746" }, { "job": 115796260413, "time": 183, "config": "source", "r": "4.6.1", "check": "OK", "artifact": "11885585900" }, { "job": 115797479142, "time": 103, "config": "wasm-release", "r": "4.6.0", "check": "OK", "artifact": "11885261757" }, { "job": 115797478943, "time": 100, "config": "windows-devel-x86_64", "r": "4.7.0", "check": "OK", "artifact": "11884818727" }, { "job": 115797479159, "time": 112, "config": "windows-release-x86_64", "r": "4.6.1", "check": "OK", "artifact": "11884753985" } ], "_upstream": "https://github.com/cran/ordcrm", "_commit": { "id": "114a63b5075eea5b7bbf49ae8c44b428c1861cad", "author": "Emily V. Dressler ", "committer": "cran-robot ", "message": "version 1.0.0\n", "time": 1478303651 }, "_maintainer": { "name": "Emily V. Dressler", "email": "emilyvdressler@gmail.com" }, "_distro": "resolute", "_registered": true, "_dependencies": [ { "package": "R", "version": ">= 3.3.1", "role": "Depends" }, { "package": "stats", "role": "Depends" }, { "package": "graphics", "role": "Depends" }, { "package": "rms", "role": "Imports" } ], "_owner": "cran", "_selfowned": false, "_usedby": 0, "_updates": [], "_tags": [], "_stars": 0, "_userbio": { "uuid": 6899542, "type": "organization", "name": "cran", "followers": 630, "description": "Unofficial read-only mirror of all CRAN R packages" }, "_downloads": { "count": 234, "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/ordcrm" }, "_searchresults": 3, "_rbuild": "4.6.1", "_assets": [ "extra/citation.cff", "extra/citation.html", "extra/citation.json", "extra/citation.txt", "extra/contents.json", "extra/manual.pdf", "extra/NEWS.html", "extra/NEWS.txt", "extra/ordcrm.html", "extra/readme.html", "extra/readme.md" ], "_realowner": "cran", "_cranurl": false, "_releases": [ { "version": "1.0.0", "date": "2016-11-04" } ], "_exports": [ "crmsimulations", "nextdose", "pseudodata" ], "_help": [ { "page": "crmsimulations", "title": "Simulations to Assess operating characteristics of proportional odds model (POM), continuation ratio (CR) Model, and binary CRM Designs", "topics": [ "crmsimulations" ] }, { "page": "nextdose", "title": "Estimates the updated model and next dose to be tested for the Proportional Odds Model (POM), Continuation Ratio (CR) Model CRM, or binary 2-parameter logistic model CRM.", "topics": [ "nextdose" ] }, { "page": "pseudodata", "title": "Pseudodata for Likelihood-Based Continual Reassessment Method (CRM) Dose Finding Designs", "topics": [ "pseudodata" ] } ], "_readme": "https://github.com/cran/ordcrm/raw/HEAD/README.md", "_rundeps": [ "backports", "base64enc", "bslib", "cachem", "checkmate", "cli", "cluster", "codetools", "colorspace", "cpp11", "data.table", "digest", "evaluate", "farver", "fastmap", "fontawesome", "foreign", "Formula", "fs", "ggplot2", "glue", "gridExtra", "gtable", "highr", "Hmisc", "htmlTable", "htmltools", "htmlwidgets", "isoband", "jquerylib", "jsonlite", "knitr", "labeling", "lattice", "lifecycle", "magrittr", "MASS", "Matrix", "MatrixModels", "memoise", "mime", "multcomp", "mvtnorm", "nlme", "nnet", "polspline", "quantreg", "R6", "rappdirs", "RColorBrewer", "rlang", "rmarkdown", "rms", "rpart", "rstudioapi", "S7", "sandwich", "sass", "scales", "SparseM", "stringi", "stringr", "survival", "TH.data", "tinytex", "vctrs", "viridisLite", "withr", "xfun", "yaml", "zoo" ], "_score": 1.6989700043360187, "_indexed": true, "_nocasepkg": "ordcrm", "_universes": [ "cran" ], "_binaries": [ { "r": "4.7.0", "os": "linux", "version": "1.0.0", "date": "2026-10-14T10:11:31.000Z", "distro": "resolute", "commit": "114a63b5075eea5b7bbf49ae8c44b428c1861cad", "fileid": "https://r2.ropensci.org/7112992f1d6a0f4ceb8031260e3bf13c14e279aa88c5a7c40c9630826e246fb9", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/cran/actions/runs/38547211317" }, { "r": "4.6.1", "os": "linux", "version": "1.0.0", "date": "2026-10-14T10:11:43.000Z", "distro": "resolute", "commit": "114a63b5075eea5b7bbf49ae8c44b428c1861cad", "fileid": "https://r2.ropensci.org/db45a454e632473d0980a16739d8943f18d515e47faa09165d2c6b2ba258642b", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/cran/actions/runs/38547211317" }, { "r": "4.6.0", "os": "wasm", "version": "1.0.0", "date": "2026-10-14T10:11:28.000Z", "commit": "114a63b5075eea5b7bbf49ae8c44b428c1861cad", "fileid": "https://r2.ropensci.org/9d612a6dc675785609c36e9a5eca70763fb42c8ac81f867017d73c1a01800669", "status": "success", "buildurl": "https://github.com/r-universe/cran/actions/runs/38547211317" }, { "r": "4.7.0", "os": "win", "version": "1.0.0", "date": "2026-10-14T10:10:57.000Z", "commit": "114a63b5075eea5b7bbf49ae8c44b428c1861cad", "fileid": "https://r2.ropensci.org/8ed8ab9d4ae01d629063a496d119e819af0d21500e96f8f79fb56b6d9313b5e9", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/cran/actions/runs/38547211317" }, { "r": "4.6.1", "os": "win", "version": "1.0.0", "date": "2026-10-14T10:11:23.000Z", "commit": "114a63b5075eea5b7bbf49ae8c44b428c1861cad", "fileid": "https://r2.ropensci.org/03d304c5c8078134c7f09690d3fa568a968e2e345623255986330dfd1dcdea08", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/cran/actions/runs/38547211317" } ] }